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Various topics in medicine relate to lesbian, gay, bisexual, and transgender people. According to the US Gay and Lesbian Medical Association , besides HIV/AIDS, issues related to LGBT health include breast and cervical cancer, hepatitis, mental health, substance use disorders, alcohol use, tobacco use, depression, access to care for transgender persons, issues surrounding marriage and family recognition, conversion therapy, refusal clause legislation, and laws that are intended to "immunize health care professionals from liability for discriminating against persons of whom they disapprove."

LGBT people may face barriers to accessing healthcare on the basis of their sexual orientation and/or gender identity or expression. Many avoid or delay care or receive inappropriate or inferior care because of perceived or real homophobia or transphobia and discrimination by healthcare providers and institutions; in other words, negative personal experience, the assumption or expectation of negative experience based on knowing of history of such experience in other LGBT people, or both.

It is often pointed out that the reason of this is heterosexism in medical care and research:

"Heterosexism can be purposeful or unconscious. These forms of discrimination limit medical research and negatively impact the health care of LGB individuals. This disparity is particularly extreme for lesbians because they have a double minority status, and experience oppression for being both female and homosexual."

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