Generic Name Oxyphenonium Bromide
Bangla Name অক্সিফেনোনিয়াম ব্রোমাইড
Available brands 4
Language

Introduction

A quaternary ammonium anticholinergic agent with peripheral side effects similar to those of atropine. It is used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. The drug has also been used in the form of eye drops for mydriatic effect. [PubChem]

Uses

For the treatment of visceral spasms

Pharmacodynamics

Oxyphenonium is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Oxyphenonium is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Oxyphenonium inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions.

Mechanism of Action

Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic).

Protein Binding

93% bound to albumin

Dosage

Average adult dosage is 10 mg (2 tablets) 4 times daily for several days. Dosage may be reduced depending on patient's response or as directed by the physician.

Frequently Asked Questions About Oxyphenonium Bromide

1. What is Oxyphenonium Bromide?

Oxyphenonium Bromide is an anticholinergic drug used to treat gastrointestinal disorders, particularly those involving smooth muscle spasms, such as peptic ulcers and irritable bowel syndrome (IBS).

2. How does Oxyphenonium Bromide work?

Oxyphenonium Bromide works by blocking the action of acetylcholine, a neurotransmitter that affects smooth muscle contractions, thus reducing spasms and pain in the gastrointestinal tract.

3. What conditions is Oxyphenonium Bromide used to treat?

Oxyphenonium Bromide is mainly used for the treatment of gastrointestinal disorders such as peptic ulcers, irritable bowel syndrome (IBS), and certain types of colic.

4. How is Oxyphenonium Bromide administered?

Oxyphenonium Bromide is typically administered orally in tablet form. It may also be available in injectable forms for more severe conditions.

5. What is the usual dosage of Oxyphenonium Bromide?

The typical oral dosage of Oxyphenonium Bromide is 1-2 tablets taken 2-3 times a day, but your doctor will determine the exact dosage based on your condition.

6. Can Oxyphenonium Bromide be taken with food?

Yes, Oxyphenonium Bromide can be taken with or without food. However, taking it with food may help reduce any potential stomach irritation.

7. What are the common side effects of Oxyphenonium Bromide?

Common side effects of Oxyphenonium Bromide include:

  • Dry mouth
  • Blurred vision
  • Dizziness
  • Constipation
  • Urinary retention

8. Can Oxyphenonium Bromide cause allergic reactions?

Yes, allergic reactions to Oxyphenonium Bromide are possible, including rashes, itching, swelling, or difficulty breathing. Seek immediate medical attention if you experience any of these symptoms.

9. Can Oxyphenonium Bromide be used for children?

Oxyphenonium Bromide is generally not recommended for children under 12 years old, unless prescribed by a doctor for specific conditions.

10. Can Oxyphenonium Bromide be taken during pregnancy?

Oxyphenonium Bromide should only be used during pregnancy if clearly needed, and the benefits outweigh the risks. Consult your doctor before using this medication while pregnant.

11. Can Oxyphenonium Bromide be used while breastfeeding?

Oxyphenonium Bromide is not recommended during breastfeeding, as it may pass into breast milk and affect the infant. Always consult your doctor before taking any medication while breastfeeding.

12. Is Oxyphenonium Bromide effective for stomach cramps?

Yes, Oxyphenonium Bromide can be effective in reducing stomach cramps caused by gastrointestinal spasms due to its antispasmodic properties.

13. Can Oxyphenonium Bromide be used for urinary problems?

Oxyphenonium Bromide is primarily used for gastrointestinal disorders, but it may also help with urinary retention caused by bladder spasms due to its anticholinergic effects.

14. Can I drink alcohol while taking Oxyphenonium Bromide?

It is advisable to avoid alcohol while taking Oxyphenonium Bromide, as alcohol can increase the sedative effects of the medication and cause drowsiness or dizziness.

15. What should I do if I miss a dose of Oxyphenonium Bromide?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once.

16. What are the contraindications of Oxyphenonium Bromide?

Oxyphenonium Bromide should not be used in patients with:

  • Glaucoma
  • Myasthenia gravis
  • Urinary retention
  • Severe gastrointestinal obstruction

17. Can Oxyphenonium Bromide be used for irritable bowel syndrome (IBS)?

Yes, Oxyphenonium Bromide is often used to relieve the smooth muscle spasms associated with irritable bowel syndrome (IBS), helping to reduce abdominal pain and discomfort.

18. Can Oxyphenonium Bromide cause constipation?

Yes, constipation is a common side effect of Oxyphenonium Bromide due to its anticholinergic properties that can reduce bowel movement frequency.

19. How long should I take Oxyphenonium Bromide?

The length of treatment with Oxyphenonium Bromide depends on the condition being treated. Your doctor will determine the appropriate duration of therapy.

20. Can Oxyphenonium Bromide cause dry mouth?

Yes, dry mouth is a common side effect of Oxyphenonium Bromide due to its anticholinergic effects. Drinking water or using sugar-free gum may help alleviate this symptom.

21. Is Oxyphenonium Bromide available over-the-counter?

No, Oxyphenonium Bromide is a prescription medication and should only be taken under the supervision of a healthcare provider.

22. Can Oxyphenonium Bromide be used for bloating?

Oxyphenonium Bromide may help relieve bloating caused by gastrointestinal spasms by reducing the muscle contractions in the digestive tract.

23. Can Oxyphenonium Bromide interact with other medications?

Yes, Oxyphenonium Bromide may interact with other medications, including other anticholinergics, antihistamines, and medications for Parkinson's disease. Always inform your doctor of all medications you are taking.

24. How should Oxyphenonium Bromide be stored?

Store Oxyphenonium Bromide in a cool, dry place, away from direct sunlight and out of reach of children.

25. Can Oxyphenonium Bromide cause dizziness?

Yes, dizziness is a possible side effect of Oxyphenonium Bromide. If you experience dizziness, avoid activities that require full alertness, such as driving or operating heavy machinery.

26. Can I take Oxyphenonium Bromide for menstrual cramps?

Oxyphenonium Bromide is not typically used for menstrual cramps, but it may help reduce abdominal pain caused by muscle spasms if prescribed by a doctor.

27. Can Oxyphenonium Bromide cause blurred vision?

Yes, blurred vision can occur as a side effect due to the drug's anticholinergic properties. This side effect is usually temporary.

28. Can Oxyphenonium Bromide cause urinary retention?

Yes, Oxyphenonium Bromide can cause urinary retention due to its effects on smooth muscle function. If you experience difficulty urinating, consult your doctor.

29. Is Oxyphenonium Bromide safe for long-term use?

Oxyphenonium Bromide should be used only as prescribed by your doctor. Prolonged use may lead to increased side effects, and regular medical reviews are recommended.

30. How soon will I feel better after taking Oxyphenonium Bromide?

Most people experience relief from symptoms within a few hours to a day after taking Oxyphenonium Bromide, but it may vary based on the severity of the condition being treated.

31. Can Oxyphenonium Bromide be used for indigestion?

Oxyphenonium Bromide may be useful for indigestion caused by spasms of the gastrointestinal tract, although it is not the first-line treatment for indigestion.

32. Can Oxyphenonium Bromide cause confusion?

In rare cases, especially in older adults, Oxyphenonium Bromide may cause confusion, memory problems, or hallucinations. Contact your doctor if these symptoms occur.

33. Can Oxyphenonium Bromide cause high blood pressure?

Oxyphenonium Bromide does not typically cause high blood pressure, but it may interact with medications for high blood pressure. Always consult your doctor before taking it if you have hypertension.

34. Can Oxyphenonium Bromide be taken with other antispasmodic drugs?

Oxyphenonium Bromide can interact with other antispasmodics, and it is important to consult your doctor before combining medications to avoid excessive side effects.

35. How does Oxyphenonium Bromide affect the heart?

Oxyphenonium Bromide can affect the heart rate by causing a slight increase in heart rate. People with heart conditions should use this drug cautiously.

36. Can Oxyphenonium Bromide affect memory?

Memory problems, such as short-term memory loss, can occur with Oxyphenonium Bromide, particularly in older adults or with long-term use.

37. Can Oxyphenonium Bromide cause sweating?

Oxyphenonium Bromide can reduce sweating in some individuals due to its anticholinergic effects, leading to dry skin and less perspiration.

38. Can Oxyphenonium Bromide be used for nausea?

Oxyphenonium Bromide is not typically used for nausea unless it is caused by gastrointestinal spasm. Anti-nausea medications are usually more effective for treating nausea.

39. What should I do if I overdose on Oxyphenonium Bromide?

If you suspect an overdose of Oxyphenonium Bromide, seek immediate medical attention. Symptoms may include severe dry mouth, dizziness, and difficulty urinating.

40. Is there a generic version of Oxyphenonium Bromide?

Yes, Oxyphenonium Bromide is available in generic versions under various brand names.

41. Can I take Oxyphenonium Bromide with other anticholinergic medications?

Taking Oxyphenonium Bromide with other anticholinergic medications may increase the risk of side effects like dry mouth, blurred vision, and urinary retention. Always consult your doctor.

42. Can Oxyphenonium Bromide be used for gastric ulcers?

Yes, Oxyphenonium Bromide can be used as part of the treatment for peptic ulcers, as it helps reduce spasms and discomfort in the stomach.

43. Does Oxyphenonium Bromide interact with antibiotics?

Oxyphenonium Bromide may interact with certain antibiotics, especially those that affect the gastrointestinal system. Always inform your doctor if you are on antibiotics.

44. Can Oxyphenonium Bromide be used for acid reflux?

Oxyphenonium Bromide is not typically used for acid reflux, as it does not address the underlying causes like acid production. Other medications are recommended for acid reflux.

45. Can Oxyphenonium Bromide be used for abdominal bloating?

Oxyphenonium Bromide can help relieve bloating caused by smooth muscle spasms in the gastrointestinal tract.

46. What happens if I miss a dose of Oxyphenonium Bromide?

If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. Do not double the dose to make up for the missed one.

47. Can Oxyphenonium Bromide cause dizziness when standing up?

Yes, dizziness upon standing up (orthostatic hypotension) can be a side effect of Oxyphenonium Bromide. Stand up slowly to avoid feeling lightheaded.

48. Can Oxyphenonium Bromide affect your skin?

Oxyphenonium Bromide may cause dry skin and reduced sweating due to its anticholinergic properties.

49. Can Oxyphenonium Bromide be used for stomach ulcers?

Oxyphenonium Bromide may be used to treat symptoms of stomach ulcers, such as pain due to smooth muscle spasms, but it is not the primary treatment for ulcer healing.

50. Can Oxyphenonium Bromide be taken with other GI medications?

Oxyphenonium Bromide can be taken with other gastrointestinal medications, but interactions should be monitored. Consult your doctor to avoid any potential issues.

Medical review

Last reviewed: 24 Jul 2026

Medically reviewed by:

This is general information, not personal medical advice. Consult a doctor before taking any medicine.

Taking medicines without doctor's advice can cause long-term problems.
Brand medicines containing Oxyphenonium Bromide