Generic Name Flucloxacillin Sodium
Bangla Name ফ্লুক্লক্সাসিলিন সোডিয়াম
Available brands 200
Language

Introduction

Antibiotic analog of cloxacillin.

Uses

Flucloxacillin is a narrow spectrum penicillin antibiotic that exerts specific activity against Gram positive organisms in skin and soft tissue infections, except those caused by methicillin resistant staphylococcus aureus (MRSA).

Used to treat bacterial infection by susceptible microorganisms.

Associated Conditions

  • Susceptible infections

Pharmacodynamics

Flucloxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Flucloxacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Flucloxacillin results from the inhibition of cell wall synthesis and is mediated through flucloxacillin binding to penicillin binding proteins (PBPs). Flucloxacillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.

Mechanism of Action

By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, flucloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that flucloxacillin interferes with an autolysin inhibitor.

Absorption

Bioavailability is 50–70% following oral administration.

Half Life

0.75–1 hour

Food Interactions

  • Take on an empty stomach.

Dosage

Oral administration:
  • Adult: 250 mg four times daily. Dosage may be doubled in severe infections. In osteomyelitis and endocarditis, up to 8 gm daily is used in 6-8 hourly divided doses.
  • Children (2-10 years): 1/2 of adult dose.
  • Children (Under 2 years): 1/4 of adult dose.
Parenteral administration:
Adult or Elderly:
  • Intramuscular Injection: 250 mg four times daily.
  • Intravenous Injection: 250 mg-1 g four times daily by slow injection over 3 to 4 minutes or by intravenous infusion.
  • All systemic doses may be doubled in severe infections: doses up to 8 g daily have been suggested for endocarditis or osteomyelitis.
Children:
  • 2-10 years: half of the adult dose.
  • Under 2 years: a quarter of the adult dose.

Frequently Asked Questions About Flucloxacillin Sodium

1. What is Flucloxacillin Sodium?

Flucloxacillin Sodium is a type of antibiotic that belongs to the class of penicillins. It is used to treat a variety of bacterial infections, especially those caused by Staphylococcus bacteria.

2. What conditions can Flucloxacillin Sodium treat?

Flucloxacillin Sodium is commonly used to treat:

  • Skin infections (such as abscesses, cellulitis, and impetigo)
  • Respiratory infections (such as pneumonia and bronchitis)
  • Bone and joint infections (such as osteomyelitis)
  • Ear infections (such as otitis media)
  • Soft tissue infections

3. How does Flucloxacillin Sodium work?

Flucloxacillin Sodium works by inhibiting the growth of bacteria. It interferes with the synthesis of the bacterial cell wall, ultimately killing the bacteria.

4. What is the usual dosage of Flucloxacillin Sodium?

The dosage of Flucloxacillin Sodium varies depending on the severity of the infection. It is typically taken every 6 to 8 hours, but the exact dosage should be prescribed by your healthcare provider.

5. Can Flucloxacillin Sodium be used for infections caused by viruses?

No, Flucloxacillin Sodium is an antibiotic that only works against bacterial infections and is not effective against viral infections such as the flu or common cold.

6. How should Flucloxacillin Sodium be taken?

Flucloxacillin Sodium can be taken orally in capsule or liquid form, or administered intravenously. Always follow your healthcare provider's instructions for the proper method of administration.

7. Are there any common side effects of Flucloxacillin Sodium?

Common side effects may include:

  • Upset stomach
  • Diarrhea
  • Nausea
  • Skin rash

8. What should I do if I miss a dose of Flucloxacillin Sodium?

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once.

9. Can Flucloxacillin Sodium be used during pregnancy?

Flucloxacillin Sodium is generally considered safe during pregnancy when prescribed by a healthcare provider. However, always consult your doctor before taking any medication during pregnancy.

10. Can Flucloxacillin Sodium be used while breastfeeding?

Flucloxacillin Sodium can pass into breast milk in small amounts. It is generally considered safe during breastfeeding, but you should consult your doctor before using it while nursing.

11. Can Flucloxacillin Sodium cause an allergic reaction?

Yes, some individuals may experience an allergic reaction to Flucloxacillin Sodium, which may include symptoms like:

  • Rash
  • Itching
  • Swelling, particularly of the face, lips, or throat
  • Breathing difficulties
If any of these symptoms occur, seek medical attention immediately.

12. Can Flucloxacillin Sodium interact with other medications?

Yes, Flucloxacillin Sodium can interact with other medications, including:

  • Warfarin (blood thinners)
  • Other antibiotics
  • Probenecid
Always inform your doctor of all the medications you're currently taking.

13. How long does Flucloxacillin Sodium take to work?

Flucloxacillin Sodium typically starts working within a few hours, but it may take a few days for the full effect to be seen. Always complete the full course of treatment, even if you feel better.

14. Can Flucloxacillin Sodium cause diarrhea?

Yes, diarrhea is a common side effect of Flucloxacillin Sodium, especially when the body is adjusting to the antibiotic. If diarrhea becomes severe or persists, contact your doctor.

15. Can Flucloxacillin Sodium be taken on an empty stomach?

Flucloxacillin Sodium is usually best taken on an empty stomach, about 1 hour before or 2 hours after meals, for optimal absorption. However, follow your doctor's recommendations.

16. Can Flucloxacillin Sodium be used to treat a cold or the flu?

No, Flucloxacillin Sodium is an antibiotic used to treat bacterial infections and is not effective against viral infections such as the common cold or flu.

17. Can Flucloxacillin Sodium cause liver problems?

In rare cases, Flucloxacillin Sodium can cause liver problems. Symptoms of liver issues may include yellowing of the skin or eyes (jaundice), dark urine, or abdominal pain. Seek medical attention if these occur.

18. Can Flucloxacillin Sodium be used for tooth infections?

Yes, Flucloxacillin Sodium can be used to treat bacterial infections in the mouth, including tooth infections caused by susceptible bacteria.

19. Can Flucloxacillin Sodium be used for urinary tract infections (UTIs)?

Flucloxacillin Sodium may be used for UTIs caused by susceptible bacteria, but other antibiotics are often preferred for treating UTIs. Consult your doctor for the best treatment.

20. Can Flucloxacillin Sodium cause nausea?

Yes, nausea is a possible side effect. Taking the medication with food or drinking plenty of fluids may help reduce nausea.

21. How should Flucloxacillin Sodium be stored?

Store Flucloxacillin Sodium at room temperature, away from moisture and heat. Keep it out of the reach of children.

22. Can Flucloxacillin Sodium be used for ear infections?

Yes, Flucloxacillin Sodium can be used to treat bacterial ear infections, such as otitis media, caused by susceptible bacteria.

23. Is Flucloxacillin Sodium effective against MRSA?

Flucloxacillin Sodium is effective against most strains of Staphylococcus aureus, but some strains, including Methicillin-resistant Staphylococcus aureus (MRSA), may be resistant. Your doctor may prescribe a different antibiotic for MRSA.

24. Can Flucloxacillin Sodium be used for chest infections?

Yes, Flucloxacillin Sodium is commonly used to treat chest infections like pneumonia or bronchitis, especially when caused by susceptible bacteria.

25. Can Flucloxacillin Sodium be used for wound infections?

Yes, Flucloxacillin Sodium is effective for treating wound infections, particularly those caused by Staphylococcus bacteria.

26. Can Flucloxacillin Sodium be used for boils?

Yes, Flucloxacillin Sodium is often prescribed to treat boils and abscesses caused by bacterial infections.

27. Can Flucloxacillin Sodium be taken with food?

Flucloxacillin Sodium is best taken on an empty stomach, but if it causes stomach upset, it may be taken with food. Follow your doctor's instructions.

28. Can Flucloxacillin Sodium be used for sinus infections?

Yes, Flucloxacillin Sodium may be used to treat sinus infections (sinusitis) caused by bacteria susceptible to the drug.

29. What should I do if I overdose on Flucloxacillin Sodium?

If you suspect an overdose, seek emergency medical attention immediately. Symptoms of an overdose may include nausea, vomiting, and diarrhea.

30. Is Flucloxacillin Sodium safe for children?

Flucloxacillin Sodium can be used in children, but the dosage must be adjusted based on the child's age and weight. Consult your doctor for appropriate dosing information.

31. Can Flucloxacillin Sodium be used for skin rashes?

Flucloxacillin Sodium may be used for skin rashes caused by bacterial infections. However, rashes caused by other factors should be evaluated by a doctor.

32. Can Flucloxacillin Sodium be used for sore throats?

Yes, Flucloxacillin Sodium may be prescribed for sore throats caused by bacterial infections, such as those caused by Streptococcus bacteria.

33. Can Flucloxacillin Sodium cause headaches?

Headaches are not a common side effect of Flucloxacillin Sodium, but they can occur in some individuals.

34. Can Flucloxacillin Sodium cause dizziness?

Flucloxacillin Sodium may cause dizziness or lightheadedness in some people. If you experience these symptoms, avoid activities that require concentration, such as driving.

35. Can Flucloxacillin Sodium be used for sepsis?

Yes, Flucloxacillin Sodium can be used to treat sepsis caused by susceptible bacteria, although it is often given in combination with other antibiotics.

36. How long should I take Flucloxacillin Sodium?

The duration of treatment with Flucloxacillin Sodium depends on the type of infection and its severity. It is important to complete the full course of antibiotics as prescribed by your doctor.

37. Can Flucloxacillin Sodium cause allergic reactions in people with penicillin allergies?

Yes, individuals who are allergic to penicillin may also be allergic to Flucloxacillin Sodium. If you have a known penicillin allergy, inform your doctor before using this medication.

38. Can Flucloxacillin Sodium cause kidney problems?

In rare cases, Flucloxacillin Sodium may cause kidney problems. Symptoms of kidney issues include changes in urination or swelling in the legs and feet. Contact your doctor if you notice any of these symptoms.

39. What is the shelf life of Flucloxacillin Sodium?

The shelf life of Flucloxacillin Sodium is typically around 2 to 3 years. Always check the expiration date on the packaging and dispose of expired medication properly.

40. Can Flucloxacillin Sodium be used to treat tooth abscesses?

Yes, Flucloxacillin Sodium can be prescribed to treat tooth abscesses caused by bacterial infections.

41. Is Flucloxacillin Sodium available over-the-counter?

No, Flucloxacillin Sodium is a prescription-only medication and should only be used under the supervision of a healthcare provider.

42. Can Flucloxacillin Sodium be used for staph infections?

Yes, Flucloxacillin Sodium is commonly used to treat staph infections, especially those caused by methicillin-sensitive Staphylococcus aureus (MSSA).

43. Can Flucloxacillin Sodium cause difficulty breathing?

Yes, difficulty breathing may occur as part of an allergic reaction. If you experience this, stop using the medication and seek immediate medical help.

44. Can Flucloxacillin Sodium be used for impetigo?

Yes, Flucloxacillin Sodium is commonly prescribed to treat impetigo, a bacterial skin infection.

45. Can Flucloxacillin Sodium be used for boils on the skin?

Yes, Flucloxacillin Sodium is effective in treating boils caused by Staphylococcus bacteria.

46. Can Flucloxacillin Sodium be used for acne?

Flucloxacillin Sodium may be used in certain cases of acne if the condition is caused by a bacterial infection. Consult your doctor for the best treatment.

47. What should I do if I experience side effects from Flucloxacillin Sodium?

If you experience side effects, inform your doctor immediately. For serious reactions, such as anaphylaxis or severe rash, seek emergency medical attention.

48. Can Flucloxacillin Sodium cause a sore throat?

A sore throat is not a common side effect, but if you develop a sore throat while using Flucloxacillin Sodium, consult your doctor.

49. Is Flucloxacillin Sodium effective for urinary tract infections (UTIs)?

Flucloxacillin Sodium is not typically the first choice for UTIs, but it can be effective for UTIs caused by susceptible bacteria.

50. Can Flucloxacillin Sodium cause a fever?

Flucloxacillin Sodium may cause a mild fever in some individuals, particularly during the initial days of treatment. If you develop a high fever or other severe symptoms, consult your doctor.

Medical review

Last reviewed: 24 Jul 2026

Medically reviewed by:

This is general information, not personal medical advice. Consult a doctor before taking any medicine.

Taking medicines without doctor's advice can cause long-term problems.
Brand medicines containing Flucloxacillin Sodium