Introduction

A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.

Citric acid was one of active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA on May 2020.

Uses

Citric acid is an anti-chelation additive used in blood collection tubes and as a flavoring and preservative agent in various cosmetic and pharmaceutical products.

Associated Conditions

Acidosis
Catheter site calcification caused by appetite
Catheter site calcification caused by struvite
Gouty Arthritis
Headache
Heartburn
Kidney Stones
Metabolic Acidosis
Blood Specimen Collection
Blood sample storage
Bowel preparation therapy
Chemical contraception
Potassium placement
Urine alkalinization therapy
Cleansing of the colon as a preparation for colonoscopy
Oral antisepsis

Toxicity

ORAL (LD50): Acute: 5040 mg/kg [Mouse]. 3000 mg/kg [Rat].

Food Interactions

No interactions found.

Dosage

1-5 years: 5 ml upto 4 times daily
6-12 years: 10 ml upto 4 times daily
>12 years & Adults: 20 ml upto 3-4 times daily

Medical review

Last reviewed: 24 Jul 2026

Medically reviewed by:

This is general information, not personal medical advice. Consult a doctor before taking any medicine.