Introduction
An imidazole antithyroid agent. Carbimazole is metabolized to methimazole, which is responsible for the antithyroid activity.
Uses
Carbimazole is a drug used for the reduction of thyroid function.
For the treatment of hyperthyroidism and thyrotoxicosis. It is also used to prepare patients for thyroidectomy.
Associated Conditions
Pharmacodynamics
Carbimazole is a carbethoxy derivative of methimazole. Its antithyroid action is due to its conversion to methimazole after absorption. It is used to treat hyperthyroidism and thyrotoxicosis.
Mechanism of Action
Carbimazole is an aitithyroid agent that decreases the uptake and concentration of inorganic iodine by thyroid, it also reduces the formation of di-iodotyrosine and thyroxine. Once converted to its active form of methimazole, it prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4.
Protein Binding
85%
Dosage
Maintenance regimen: The dose is gradually reduced to maintain a euthyroid state. The final dosage is usually in the range of 5-15 mg/day which may be taken as a single daily dose.
Neonates & Children below 12 years: The usual initial dose is 250 mcg/Kg/day in divided doses.
Duration of treatment: 18 to 24 months.
