Vis-A Soft Gelatin Capsule

Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of carotenoids found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.

Vis-A Soft Gelatin Capsule 50000 IU is a vitamin important for retinal function that is used clinically to correct vitamin A deficiency.

For the treatment of vitamin A deficiency.

• Deficiency
• Vis-A Soft Gelatin Capsule 50000 IU
• Deficiency
• Vitamin D
• Degenerative Retinal Disorders
• Disorder of the Epithelium
• Disorder of the Mesoderm
• Inner ear disorder
• Vitamin Deficiency
• Vitamin E Deficiency
• Nutritional supplementation

Vis-A Soft Gelatin Capsule 50000 IU is effective for the treatment of Vis-A Soft Gelatin Capsule 50000 IU deficiency. Vis-A Soft Gelatin Capsule 50000 IU refers to a group of fat-soluble substances that are structurally related to and possess the biological activity of the parent substance of the group called all-trans retinol or retinol. Vis-A Soft Gelatin Capsule 50000 IU plays vital roles in vision, epithelial differentiation, growth, reproduction, pattern formation during embryogenesis, bone development, hematopoiesis and brain development. It is also important for the maintenance of the proper functioning of the immune system.

Vision:Vis-A Soft Gelatin Capsule 50000 IU (all-trans retinol) is converted in the retina to the 11-cis-isomer of retinaldehyde or 11-cis-retinal. 11-cis-retinal functions in the retina in the transduction of light into the neural signals necessary for vision. 11-cis-retinal, while attached to opsin in rhodopsin is isomerized to all-trans-retinal by light. This is the event that triggers the nerve impulse to the brain which allows for the perception of light. All-trans-retinal is then released from opsin and reduced to all-trans-retinol. All-trans-retinol is isomerized to 11-cis-retinol in the dark, and then oxidized to 11-cis-retinal. 11-cis-retinal recombines with opsin to re-form rhodopsin. Night blindness or defective vision at low illumination results from a failure to re-synthesize 11-cis retinal rapidly.
Epithelial differentiation: The role of Vis-A Soft Gelatin Capsule 50000 IU in epithelial differentiation, as well as in other physiological processes, involves the binding of Vis-A Soft Gelatin Capsule 50000 IU to two families of nuclear retinoid receptors (retinoic acid receptors, RARs; and retinoid-X receptors, RXRs). These receptors function as ligand-activated transcription factors that modulate gene transcription. When there is not enough Vis-A Soft Gelatin Capsule 50000 IU to bind these receptors, natural cell differentiation and growth are interrupted.

Readily absorbed from the normal gastrointestinal tract

<5% of circulating vitamin A is bound to lipoproteins in blood in normal condition, but may be up to 65% when hepatic stores are saturated because of excessive intake. When released from liver, vitamin A is bound to retinol-binding protein (RBP). Most vitamin A circulates in the form of retinol bound to RBP.

1.9 hours

Acute toxicity to vitamin A can occur when adults or children ingest >100x or >20x the RDA, respectively, over a period of hours or a few days. The RDA for vitamin A differs depending on age and sex and can range from 300 - 900 μg retinol activity equivalents (RAE) per day. Symptoms of acute systemic toxicity generally include mucocutaneous involvement (e.g. xerosis, cheilitis, skin peeling) and may involve mental status changes. Children are typically more susceptible to acute vitamin A toxicity - daily intakes of as little as 1500 IU/kg have been observed to result in toxicity.

Chronic vitamin A toxicity can develop following the long-term ingestion of high vitamin A doses. While there is a wide variation in the lowest toxic vitamin A dose, the ingestion of >25 000 IU daily for 6 years or 100,000 IU daily for 6 months is considered to be toxic. Chronic vitamin A toxicity can affect many organ systems and can lead to the development of osteoporosis and CNS effects (e.g. headaches).

No interactions found.

• Night blindness, Bitot's spots, Xerophthalmia: 200000 IU 1st day, 2nd day, 14th day
• Measles: 200000 IU 1st day, 2nd day
• Diarrhoea, Respiratory tract infection: 200000 IU every time after disease
• Severe malnutrition: 200000 IU single-dose or as directed by the registered physician.