Trolen Capsule

Trolen Capsule 25 mg

Trolen Capsule 25 mg is a muscle relaxant drug that belongs to the hydantoin class of agents. It is used for the treatment of spasticity and to reduce muscle spasticity associated with probably irreversible conditions like spinal cord injury, cerebral palsy, multiple sclerosis etc. It is also used to treat malignant hyperthermia and is often used in conjunction with anesthetic agents.

Uses For

Trolen Capsule 25 mg is used for the treatment of muscle spasticity and is used in patients who have conditions such as spinal cord injury, cerebral palsy, multiple sclerosis, etc. It is also used to treat malignant hyperthermia.

Brand Name	Trolen
Type	Capsule
Weight	25 mg
Generic	Dantrolene Sodium
Manufacturer	Drug International Ltd.
Available in	English বাংলা

Mechanism of Action

Trolen Capsule 25 mg works mainly by blocking the release of calcium ions (Ca2+) from the sarcoplasmic reticulum in skeletal muscles, which prevents calcium ions from binding to the troponin-C region of the muscle, and therefore the muscle remains in a relaxed state. This action interferes with excitation-contraction coupling and leads to the reduction in spasticity.

How Long Does It Take to Work?

It depends on the individual patient as to how long it takes for Trolen Capsule 25 mg to work. Generally, patients are expected to experience relief within 3 to 4 days of starting treatment with this medication.

Absorption

Trolen Capsule 25 mg is incompletely and variably absorbed from the gastrointestinal tract after oral administration, and peak concentrations are reached within 1 to 3 hours of ingestion.

Route of Elimination

The main route of elimination for Trolen Capsule 25 mg is via the biliary system via faecal elimination.

Dosage

For Use in Chronic Spasticity:

Adults: The following gradual titration schedule is suggested. Some patients will not respond until higher daily dosage is achieved. Each dosage level should be maintained for seven days to determine the patient's response. If no further benefit is observed at the next higher dose, dosage should be decreased to the previous lower dose.
Starting dose is 25 mg twice per day and it can be increased to 25-50 mg per day per week. Maximum accepted dosage is 400 mg per day.
Paediatric Patients: The following gradual titration schedule is suggested. Some patients will not respond until higher daily dosage is achieved. Each dosage level should be maintained for seven days to determine the patient's response. If no further benefit is observed at the next higher dose, dosage should be decreased to the previous lower dose.
0.5 mg/kg once daily for seven days, then 0.5 mg/kg 3 times for 7 days, 1 mg/kg 3 times for 7 days, 2 mg/kg 3 times a day, Therapy with a dose 4 times daily may be necessary for some individuals.

For Malignant Hyperthermia

Preoperatively: Administer 4 to 8 mg/kg/day of oral Dantrolene in 3 or 4 divided doses for one or two days prior to surgery, with the last dose being given approximately 3 to 4 hours before scheduled surgery with a minimum of water.
Post Crisis Follow-up: Oral Dantrolene should also be administered following a malignant hyperthermia crisis, in doses of 4 to 8 mg/kg per day in four divided doses, for a one to three day period to prevent recurrence of the manifestations of malignant hyperthermia.

The recommended daily dosage of Trolen Capsule 25 mg for the treatment of spasticity varies with the age of the patient. It is typically started at 2.5 mg/kg/day and increased gradually to a maximum of 7.5 mg/kg/day in divided doses. The dosage should not exceed 4 g/day. Patients should be monitored for drug accumulation by regular blood tests.

Administration

Trolen Capsule 25 mg should be taken orally with meals and at bedtime with the last dose not given before sleeping. It should be taken exactly as prescribed by a physician and close medical monitoring is recommended.

Side Effect

The most common side effects associated with Trolen Capsule 25 mg use are nausea, vomiting, stomach pain or cramps, sleepiness, dizziness, blurred vision, headache and fatigue. In some cases, patients may also experience decreased muscle strength, weakness, depression, anxiety or increased sensitivity to sunlight.

Toxicity

Trolen Capsule 25 mg is generally well-tolerated but it may cause toxic effects in overdose, such as seizures, dysrhythmia, coma and death. In case of an overdose, medical attention should be sought immediately.

Precaution

Trolen Capsule 25 mg should be used with caution in patients with liver disease as it is metabolized in the liver. It should also be used with caution in patients with Parkinson's disease, epilepsy or a history of depression, as they may be more sensitive to its effects. Patients should be monitored regularly while on this medication.

Interaction

Trolen Capsule 25 mg may interact with other drugs such as phenytoin, nifedipine, amphotericin B or any anesthetic agents. Care should be taken to ensure that the patient is not taking any other medications that may interact with Trolen Capsule 25 mg.

Disease Interaction

Trolen Capsule 25 mg should be used with caution in patients with liver disease, as it is metabolized in the liver. In addition, it should be used with caution in patients with Parkinson's disease, epilepsy or a history of depression, as they may be more sensitive to its effects.

Drug Interaction

Food Interaction

Trolen Capsule 25 mg may interact with certain foods and beverages, so it is important to check with your physician or pharmacist before taking this medication with any food or beverage.

Pregnancy Use

Trolen Capsule 25 mg is not recommended for use in pregnant women as there is insufficient evidence to determine the safety of this medication in pregnant women. It is important to consult your physician before taking this medication if you are pregnant or if you are planning to become pregnant.

Lactation Use

Trolen Capsule 25 mg is not recommended for use in lactating women as there is insufficient evidence to determine the safety of this medication in lactating women. It is important to consult your physician before taking this medication if you are breast-feeding or plan to breast-feed.

Acute Overdose

Signs and symptoms of an acute overdose of Trolen Capsule 25 mg may include seizures, dysrhythmias, coma and death. In case of an overdose, emergency medical attention should be sought immediately.

Contraindication

Trolen Capsule 25 mg is contraindicated in patients with an allergy to it or any of its components. It should also be avoided in patients with a history of hepatic damage or liver disease, and in those who are taking other medications that may interact with it.

Use Direction

Trolen Capsule 25 mg should be taken exactly as prescribed by a physician and close medical monitoring is recommended. It is usually taken orally with meals and at bedtime with the last dose not given before sleeping.

Storage Condition

Trolen Capsule 25 mg should be stored in a cool, dry place, away from extremes of temperature and moisture. It should be kept in a secure place, out of the reach of children and pets.