Travelit Tablet

Introduction

Travelit Tablet 50 mg is an antihistamine commonly used to treat nausea, vomiting, and dizziness associated with motion sickness and vertigo. It is a first-generation antihistamine with sedative properties that help to manage symptoms related to inner ear disorders and travel-related nausea.

Uses

Travelit Tablet 50 mg is primarily used for:

Motion Sickness: To prevent and treat nausea, vomiting, and dizziness associated with travel or motion.
Vertigo: To relieve symptoms of vertigo and dizziness caused by vestibular disorders.
Postoperative Nausea: To manage nausea and vomiting following surgery, though other medications are typically preferred.

Brand Name	Travelit
Type	Tablet
Weight	50 mg
Generic	Cyclizine Hydrochloride
Manufacturer	Sharif Pharmaceuticals Ltd.
Available in	English বাংলা

Mechanism of Action

Travelit Tablet 50 mg works by blocking histamine H1 receptors in the brain, particularly in the vestibular system, which helps to reduce symptoms of nausea and dizziness. It also has anticholinergic properties that contribute to its antiemetic effects.

How Long Does It Take to Work?

The onset of action for Travelit Tablet 50 mg is typically within 30 minutes to 1 hour after oral administration. Its effects generally last for about 4 to 6 hours, making it effective for short-term management of symptoms.

Absorption

Travelit Tablet 50 mg is well absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are usually reached within 2 to 3 hours.

Route of Elimination

The drug is metabolized primarily in the liver. It is excreted mainly in the urine as metabolites, with a small amount being eliminated in the feces.

Dosage

Motion Sickness:

Adults: 1 Tablet (50 mg)
Children: (6 years & above): 1/2 Tablet (25 mg). 1 tablet should be taken at least 30 minutes before journey (before or after meal), repeat 1 tablet if journey is more than 6 hours

Postoperative Nausea & Vomiting, Meniere's disease:

Adults: 1 Tablet (50 mg) every 6-8 hours daily
Children: (6 years & above): 1/2 Tablet (25 mg) every 6-8 hours daily

The typical dosage of Travelit Tablet 50 mg is:

Adults: 50 mg orally, taken 30 minutes before travel, and repeated every 4 to 6 hours as needed, up to a maximum of 200 mg per day.
Children (over 6 years): 25 mg orally, taken 30 minutes before travel, and repeated every 6 to 8 hours as needed, up to a maximum of 75 mg per day.

Administration

Travelit Tablet 50 mg is administered orally in the form of tablets or liquid. It is best taken with water and can be taken with or without food.

Side Effects

Common side effects include:

Drowsiness
Dizziness
Dry mouth
Constipation
Blurred vision

Serious side effects, though rare, may include severe allergic reactions, confusion, and difficulty urinating.

Toxicity

Toxicity may occur with excessive doses and can lead to symptoms such as severe drowsiness, agitation, hallucinations, and seizures. Immediate medical attention is required in case of overdose.

Precautions

Use Travelit Tablet 50 mg with caution in patients with a history of glaucoma, urinary retention, or respiratory conditions such as asthma. It may impair the ability to perform tasks requiring mental alertness, such as driving.

Interaction

Travelit Tablet 50 mg may interact with other central nervous system depressants, such as alcohol, benzodiazepines, and opioids, potentially enhancing sedative effects. Inform your healthcare provider of all medications you are taking.

Disease Interaction

Use with caution in patients with liver impairment, as it may affect the metabolism of the drug. It should also be used with care in patients with cardiovascular disease due to potential anticholinergic effects.

Drug Interaction

Interactions may occur with:

Other Antihistamines: Increased risk of additive anticholinergic effects.
CNS Depressants: Enhanced sedation and drowsiness.
Alcohol: Increased risk of central nervous system depression.

Food Interactions

There are no specific food interactions with Travelit Tablet 50 mg. However, it is advisable to avoid alcohol and other sedatives while taking this medication.

Pregnancy Use

Travelit Tablet 50 mg is classified as Category B by the FDA, indicating that it is generally considered safe during pregnancy but should be used only if clearly needed. Consult your healthcare provider if you are pregnant or planning to become pregnant.

Lactation Use

The safety of Travelit Tablet 50 mg during lactation is not well established. It is recommended to avoid use during breastfeeding unless absolutely necessary and to consult your healthcare provider for alternative options.

Acute Overdose

In case of acute overdose, symptoms may include severe drowsiness, hallucinations, seizures, and anticholinergic effects. Seek immediate medical attention if an overdose is suspected.

Contraindication

Travelit Tablet 50 mg is contraindicated in individuals with hypersensitivity to the drug or any of its components. It should be avoided in patients with certain pre-existing conditions, such as narrow-angle glaucoma and severe prostatic hypertrophy.

Use Direction

Follow the prescribed dosage and administration instructions. Do not exceed the recommended dose or frequency of use. Consult your healthcare provider for any changes in the treatment regimen.

Storage Conditions

Store Travelit Tablet 50 mg at room temperature, away from direct light and moisture. Keep the medication out of reach of children and do not use beyond the expiration date.