Brand Name Topflu
Type Powder for Suspension
Weight 125 mg/5 ml
Generic Flucloxacillin Sodium
Manufacturer Al-Madina Pharmaceuticals Ltd.
Price 100 ml bottle: ৳ 70.00

About Topflu

Topflu Powder for Suspension (Al-Madina Pharmaceuticals Ltd.) is a brand medicine containing the generic Flucloxacillin Sodium . Current listed price in Bangladesh: 100 ml bottle: ৳ 70.00.

Medical information for Topflu Powder for Suspension 125 mg/5 ml

Uses, dosage, side effects, and safety details below apply to Topflu Powder for Suspension 125 mg/5 ml (generic: Flucloxacillin Sodium). This is general information — consult a doctor before use.

Introduction

Antibiotic analog of cloxacillin.

Uses

Flucloxacillin is a narrow spectrum penicillin antibiotic that exerts specific activity against Gram positive organisms in skin and soft tissue infections, except those caused by methicillin resistant staphylococcus aureus (MRSA).

Used to treat bacterial infection by susceptible microorganisms.

Associated Conditions

  • Susceptible infections

Pharmacodynamics

Flucloxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Flucloxacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Flucloxacillin results from the inhibition of cell wall synthesis and is mediated through flucloxacillin binding to penicillin binding proteins (PBPs). Flucloxacillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.

Mechanism of Action

By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, flucloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that flucloxacillin interferes with an autolysin inhibitor.

Absorption

Bioavailability is 50–70% following oral administration.

Half Life

0.75–1 hour

Food Interactions

  • Take on an empty stomach.

Dosage

Oral administration:
  • Adult: 250 mg four times daily. Dosage may be doubled in severe infections. In osteomyelitis and endocarditis, up to 8 gm daily is used in 6-8 hourly divided doses.
  • Children (2-10 years): 1/2 of adult dose.
  • Children (Under 2 years): 1/4 of adult dose.
Parenteral administration:
Adult or Elderly:
  • Intramuscular Injection: 250 mg four times daily.
  • Intravenous Injection: 250 mg-1 g four times daily by slow injection over 3 to 4 minutes or by intravenous infusion.
  • All systemic doses may be doubled in severe infections: doses up to 8 g daily have been suggested for endocarditis or osteomyelitis.
Children:
  • 2-10 years: half of the adult dose.
  • Under 2 years: a quarter of the adult dose.

Frequently Asked Questions About Topflu Powder for Suspension 125 mg/5 ml

1. What is Topflu Powder for Suspension 125 mg/5 ml?

Topflu Powder for Suspension 125 mg/5 ml is a type of antibiotic that belongs to the class of penicillins. It is used to treat a variety of bacterial infections, especially those caused by Staphylococcus bacteria.

2. What conditions can Topflu Powder for Suspension 125 mg/5 ml treat?

Topflu Powder for Suspension 125 mg/5 ml is commonly used to treat:

  • Skin infections (such as abscesses, cellulitis, and impetigo)
  • Respiratory infections (such as pneumonia and bronchitis)
  • Bone and joint infections (such as osteomyelitis)
  • Ear infections (such as otitis media)
  • Soft tissue infections

3. How does Topflu Powder for Suspension 125 mg/5 ml work?

Topflu Powder for Suspension 125 mg/5 ml works by inhibiting the growth of bacteria. It interferes with the synthesis of the bacterial cell wall, ultimately killing the bacteria.

4. What is the usual dosage of Topflu Powder for Suspension 125 mg/5 ml?

The dosage of Topflu Powder for Suspension 125 mg/5 ml varies depending on the severity of the infection. It is typically taken every 6 to 8 hours, but the exact dosage should be prescribed by your healthcare provider.

5. Can Topflu Powder for Suspension 125 mg/5 ml be used for infections caused by viruses?

No, Topflu Powder for Suspension 125 mg/5 ml is an antibiotic that only works against bacterial infections and is not effective against viral infections such as the flu or common cold.

6. How should Topflu Powder for Suspension 125 mg/5 ml be taken?

Topflu Powder for Suspension 125 mg/5 ml can be taken orally in capsule or liquid form, or administered intravenously. Always follow your healthcare provider's instructions for the proper method of administration.

7. Are there any common side effects of Topflu Powder for Suspension 125 mg/5 ml?

Common side effects may include:

  • Upset stomach
  • Diarrhea
  • Nausea
  • Skin rash

8. What should I do if I miss a dose of Topflu Powder for Suspension 125 mg/5 ml?

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once.

9. Can Topflu Powder for Suspension 125 mg/5 ml be used during pregnancy?

Topflu Powder for Suspension 125 mg/5 ml is generally considered safe during pregnancy when prescribed by a healthcare provider. However, always consult your doctor before taking any medication during pregnancy.

10. Can Topflu Powder for Suspension 125 mg/5 ml be used while breastfeeding?

Topflu Powder for Suspension 125 mg/5 ml can pass into breast milk in small amounts. It is generally considered safe during breastfeeding, but you should consult your doctor before using it while nursing.

11. Can Topflu Powder for Suspension 125 mg/5 ml cause an allergic reaction?

Yes, some individuals may experience an allergic reaction to Topflu Powder for Suspension 125 mg/5 ml, which may include symptoms like:

  • Rash
  • Itching
  • Swelling, particularly of the face, lips, or throat
  • Breathing difficulties
If any of these symptoms occur, seek medical attention immediately.

12. Can Topflu Powder for Suspension 125 mg/5 ml interact with other medications?

Yes, Topflu Powder for Suspension 125 mg/5 ml can interact with other medications, including:

  • Warfarin (blood thinners)
  • Other antibiotics
  • Probenecid
Always inform your doctor of all the medications you're currently taking.

13. How long does Topflu Powder for Suspension 125 mg/5 ml take to work?

Topflu Powder for Suspension 125 mg/5 ml typically starts working within a few hours, but it may take a few days for the full effect to be seen. Always complete the full course of treatment, even if you feel better.

14. Can Topflu Powder for Suspension 125 mg/5 ml cause diarrhea?

Yes, diarrhea is a common side effect of Topflu Powder for Suspension 125 mg/5 ml, especially when the body is adjusting to the antibiotic. If diarrhea becomes severe or persists, contact your doctor.

15. Can Topflu Powder for Suspension 125 mg/5 ml be taken on an empty stomach?

Topflu Powder for Suspension 125 mg/5 ml is usually best taken on an empty stomach, about 1 hour before or 2 hours after meals, for optimal absorption. However, follow your doctor's recommendations.

16. Can Topflu Powder for Suspension 125 mg/5 ml be used to treat a cold or the flu?

No, Topflu Powder for Suspension 125 mg/5 ml is an antibiotic used to treat bacterial infections and is not effective against viral infections such as the common cold or flu.

17. Can Topflu Powder for Suspension 125 mg/5 ml cause liver problems?

In rare cases, Topflu Powder for Suspension 125 mg/5 ml can cause liver problems. Symptoms of liver issues may include yellowing of the skin or eyes (jaundice), dark urine, or abdominal pain. Seek medical attention if these occur.

18. Can Topflu Powder for Suspension 125 mg/5 ml be used for tooth infections?

Yes, Topflu Powder for Suspension 125 mg/5 ml can be used to treat bacterial infections in the mouth, including tooth infections caused by susceptible bacteria.

19. Can Topflu Powder for Suspension 125 mg/5 ml be used for urinary tract infections (UTIs)?

Topflu Powder for Suspension 125 mg/5 ml may be used for UTIs caused by susceptible bacteria, but other antibiotics are often preferred for treating UTIs. Consult your doctor for the best treatment.

20. Can Topflu Powder for Suspension 125 mg/5 ml cause nausea?

Yes, nausea is a possible side effect. Taking the medication with food or drinking plenty of fluids may help reduce nausea.

21. How should Topflu Powder for Suspension 125 mg/5 ml be stored?

Store Topflu Powder for Suspension 125 mg/5 ml at room temperature, away from moisture and heat. Keep it out of the reach of children.

22. Can Topflu Powder for Suspension 125 mg/5 ml be used for ear infections?

Yes, Topflu Powder for Suspension 125 mg/5 ml can be used to treat bacterial ear infections, such as otitis media, caused by susceptible bacteria.

23. Is Topflu Powder for Suspension 125 mg/5 ml effective against MRSA?

Topflu Powder for Suspension 125 mg/5 ml is effective against most strains of Staphylococcus aureus, but some strains, including Methicillin-resistant Staphylococcus aureus (MRSA), may be resistant. Your doctor may prescribe a different antibiotic for MRSA.

24. Can Topflu Powder for Suspension 125 mg/5 ml be used for chest infections?

Yes, Topflu Powder for Suspension 125 mg/5 ml is commonly used to treat chest infections like pneumonia or bronchitis, especially when caused by susceptible bacteria.

25. Can Topflu Powder for Suspension 125 mg/5 ml be used for wound infections?

Yes, Topflu Powder for Suspension 125 mg/5 ml is effective for treating wound infections, particularly those caused by Staphylococcus bacteria.

26. Can Topflu Powder for Suspension 125 mg/5 ml be used for boils?

Yes, Topflu Powder for Suspension 125 mg/5 ml is often prescribed to treat boils and abscesses caused by bacterial infections.

27. Can Topflu Powder for Suspension 125 mg/5 ml be taken with food?

Topflu Powder for Suspension 125 mg/5 ml is best taken on an empty stomach, but if it causes stomach upset, it may be taken with food. Follow your doctor's instructions.

28. Can Topflu Powder for Suspension 125 mg/5 ml be used for sinus infections?

Yes, Topflu Powder for Suspension 125 mg/5 ml may be used to treat sinus infections (sinusitis) caused by bacteria susceptible to the drug.

29. What should I do if I overdose on Topflu Powder for Suspension 125 mg/5 ml?

If you suspect an overdose, seek emergency medical attention immediately. Symptoms of an overdose may include nausea, vomiting, and diarrhea.

30. Is Topflu Powder for Suspension 125 mg/5 ml safe for children?

Topflu Powder for Suspension 125 mg/5 ml can be used in children, but the dosage must be adjusted based on the child's age and weight. Consult your doctor for appropriate dosing information.

31. Can Topflu Powder for Suspension 125 mg/5 ml be used for skin rashes?

Topflu Powder for Suspension 125 mg/5 ml may be used for skin rashes caused by bacterial infections. However, rashes caused by other factors should be evaluated by a doctor.

32. Can Topflu Powder for Suspension 125 mg/5 ml be used for sore throats?

Yes, Topflu Powder for Suspension 125 mg/5 ml may be prescribed for sore throats caused by bacterial infections, such as those caused by Streptococcus bacteria.

33. Can Topflu Powder for Suspension 125 mg/5 ml cause headaches?

Headaches are not a common side effect of Topflu Powder for Suspension 125 mg/5 ml, but they can occur in some individuals.

34. Can Topflu Powder for Suspension 125 mg/5 ml cause dizziness?

Topflu Powder for Suspension 125 mg/5 ml may cause dizziness or lightheadedness in some people. If you experience these symptoms, avoid activities that require concentration, such as driving.

35. Can Topflu Powder for Suspension 125 mg/5 ml be used for sepsis?

Yes, Topflu Powder for Suspension 125 mg/5 ml can be used to treat sepsis caused by susceptible bacteria, although it is often given in combination with other antibiotics.

36. How long should I take Topflu Powder for Suspension 125 mg/5 ml?

The duration of treatment with Topflu Powder for Suspension 125 mg/5 ml depends on the type of infection and its severity. It is important to complete the full course of antibiotics as prescribed by your doctor.

37. Can Topflu Powder for Suspension 125 mg/5 ml cause allergic reactions in people with penicillin allergies?

Yes, individuals who are allergic to penicillin may also be allergic to Topflu Powder for Suspension 125 mg/5 ml. If you have a known penicillin allergy, inform your doctor before using this medication.

38. Can Topflu Powder for Suspension 125 mg/5 ml cause kidney problems?

In rare cases, Topflu Powder for Suspension 125 mg/5 ml may cause kidney problems. Symptoms of kidney issues include changes in urination or swelling in the legs and feet. Contact your doctor if you notice any of these symptoms.

39. What is the shelf life of Topflu Powder for Suspension 125 mg/5 ml?

The shelf life of Topflu Powder for Suspension 125 mg/5 ml is typically around 2 to 3 years. Always check the expiration date on the packaging and dispose of expired medication properly.

40. Can Topflu Powder for Suspension 125 mg/5 ml be used to treat tooth abscesses?

Yes, Topflu Powder for Suspension 125 mg/5 ml can be prescribed to treat tooth abscesses caused by bacterial infections.

41. Is Topflu Powder for Suspension 125 mg/5 ml available over-the-counter?

No, Topflu Powder for Suspension 125 mg/5 ml is a prescription-only medication and should only be used under the supervision of a healthcare provider.

42. Can Topflu Powder for Suspension 125 mg/5 ml be used for staph infections?

Yes, Topflu Powder for Suspension 125 mg/5 ml is commonly used to treat staph infections, especially those caused by methicillin-sensitive Staphylococcus aureus (MSSA).

43. Can Topflu Powder for Suspension 125 mg/5 ml cause difficulty breathing?

Yes, difficulty breathing may occur as part of an allergic reaction. If you experience this, stop using the medication and seek immediate medical help.

44. Can Topflu Powder for Suspension 125 mg/5 ml be used for impetigo?

Yes, Topflu Powder for Suspension 125 mg/5 ml is commonly prescribed to treat impetigo, a bacterial skin infection.

45. Can Topflu Powder for Suspension 125 mg/5 ml be used for boils on the skin?

Yes, Topflu Powder for Suspension 125 mg/5 ml is effective in treating boils caused by Staphylococcus bacteria.

46. Can Topflu Powder for Suspension 125 mg/5 ml be used for acne?

Topflu Powder for Suspension 125 mg/5 ml may be used in certain cases of acne if the condition is caused by a bacterial infection. Consult your doctor for the best treatment.

47. What should I do if I experience side effects from Topflu Powder for Suspension 125 mg/5 ml?

If you experience side effects, inform your doctor immediately. For serious reactions, such as anaphylaxis or severe rash, seek emergency medical attention.

48. Can Topflu Powder for Suspension 125 mg/5 ml cause a sore throat?

A sore throat is not a common side effect, but if you develop a sore throat while using Topflu Powder for Suspension 125 mg/5 ml, consult your doctor.

49. Is Topflu Powder for Suspension 125 mg/5 ml effective for urinary tract infections (UTIs)?

Topflu Powder for Suspension 125 mg/5 ml is not typically the first choice for UTIs, but it can be effective for UTIs caused by susceptible bacteria.

50. Can Topflu Powder for Suspension 125 mg/5 ml cause a fever?

Topflu Powder for Suspension 125 mg/5 ml may cause a mild fever in some individuals, particularly during the initial days of treatment. If you develop a high fever or other severe symptoms, consult your doctor.

Medical review

Last reviewed: 24 Jul 2026

Medically reviewed by:

This is general information, not personal medical advice. Consult a doctor before taking any medicine.

Taking medicines without doctor's advice can cause long-term problems.
Dr. Md. Nurul Hoque Miah

Dr. Md. Nurul Hoque Miah

Pain, Arthritis, Sports Injury, Physical Medicine & Rehabilitation Specialist

Call Doctor
Dr. Hasina Wahab

Dr. Hasina Wahab

Gynecology, Obstetrics Specialist & Surgeon

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