Introduction
Serifen Tablet 400 mg, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID). It is a pharmacologically effective enantiomer of racemic ibuprofen that differs in physicochemical properties. It is proposed to be more pharmacologically active and tolerable with a better safety profile than ibuprofen due to higher concentration of active S enantiomer. Serifen Tablet 400 mg has a slower dissolution rate in the simulated gastric and enteric juices compared with the racemic ibuprofen and displays improved oral bioavilability . For Metabolism, Enzymes, Carriers, Transporters Sections, refer to Ibuprofen.
Uses
Serifen Tablet 400 mg is a pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation.
For more information, refer to ibuprofen.
Associated Conditions
Pharmacodynamics
For more information, refer to ibuprofen.
Mechanism of Action
Like common NSAIDs, dexibuprofen is an active enantiomer of ibuprofen that suppresses the prostanoid synthesis in the inflammatory cells via inhibition of the COX-2 isoform of the arachidonic acid COX. For more information, refer to ibuprofen.
Absorption
The time it take to reach peak plasma concentration is 2.25-5 hours post-administration of oral tablets containing 300mg of dexibuprofen. For more information, refer to ibuprofen.
Volume of Distribution
For more information, refer to ibuprofen.
Protein Binding
For more information, refer to ibuprofen.
Route of Elimination
Mainly renal excretion. For more information, refer to ibuprofen.
Half Life
Oral tablets containing 300mg of dexibuprofen results in 2.2-4.7 hours . For more information, refer to ibuprofen.
Clearance
For more information, refer to ibuprofen.
Toxicity
Oral LD50 value in rats is 636 mg/kg. For more information, refer to ibuprofen.
Dosage
The recommended dosage: 600-900 mg Serifen Tablet 400 mg per day, at 2-3 divided doses. The dosage can be raised temporarily up to 1200 mg Serifen Tablet 400 mg per day in patients with acute disorders or exacerbations. The maximum daily dose is 1200 mg.
At dysmenorrhea: A dosage of 600 up to 900 mg Serifen Tablet 400 mg per day, at a divided dose.
