Inflam-D Tablet

Introduction

Inflam-D Tablet 400 mg is a nonsteroidal anti-inflammatory drug (NSAID) and is the active enantiomer of ibuprofen. It is used to relieve pain, reduce inflammation, and lower fever.

Uses

Inflam-D Tablet 400 mg is commonly used for:

Managing mild to moderate pain, such as headaches, dental pain, or musculoskeletal pain.
Reducing inflammation in conditions such as arthritis.
Relieving symptoms associated with fever.

Brand Name	Inflam-D
Type	Tablet
Weight	400 mg
Generic	Dexibuprofen
Manufacturer	Sanofi Bangladesh Ltd.
Available in	English বাংলা

Mechanism of Action

Inflam-D Tablet 400 mg works by inhibiting the activity of cyclooxygenase (COX) enzymes, particularly COX-2, which are involved in the synthesis of prostaglandins. Prostaglandins are compounds that mediate inflammation, pain, and fever. By reducing prostaglandin production, dexibuprofen alleviates these symptoms.

How Long Does It Take to Work?

Inflam-D Tablet 400 mg typically begins to work within 30 to 60 minutes after oral administration. Peak effects are usually observed within 1 to 2 hours. The duration of effect can last for 4 to 6 hours.

Absorption

Inflam-D Tablet 400 mg is well absorbed from the gastrointestinal tract. It reaches peak plasma concentrations approximately 1 to 2 hours after oral administration.

Route of Elimination

Inflam-D Tablet 400 mg is primarily metabolized in the liver. Its metabolites are then excreted mainly through the kidneys, with a small amount eliminated via the bile.

Dosage

The dosage must be adjusted to the seriousness of the syndrome and the complaints of the patient. During chronic pain, the dosage must be adapted to the lowest effective dose.

The recommended dosage: 600-900 mg Dexibuprofen per day, at 2-3 divided doses. The dosage can be raised temporarily up to 1200 mg Dexibuprofen per day in patients with acute disorders or exacerbations. The maximum daily dose is 1200 mg.

At dysmenorrhea: A dosage of 600 up to 900 mg Dexibuprofen per day, at a divided dose.

Typical dosages for dexibuprofen are:

For pain relief: 200 mg to 400 mg every 4 to 6 hours as needed, not exceeding 1,200 mg per day.
For inflammatory conditions: The dose may vary based on severity and clinical response, but it is generally within the same range as for pain relief.

Dosage may need to be adjusted based on individual patient factors and medical advice.

Administration

Inflam-D Tablet 400 mg is administered orally, typically in the form of tablets or capsules. It should be taken with food or milk to minimize gastrointestinal irritation.

Side Effects

Common side effects include:

Gastrointestinal issues such as nausea, vomiting, or abdominal pain.
Headache or dizziness.
Rash or itching.

Serious side effects may include gastrointestinal bleeding, renal impairment, or cardiovascular issues. Seek medical attention if severe side effects occur.

Toxicity

In case of overdose, symptoms may include severe nausea, vomiting, abdominal pain, dizziness, and tinnitus. Treatment generally involves supportive care, including monitoring and maintaining adequate hydration. Activated charcoal may be used if overdose is recent.

Precautions

Precautions include:

Use with caution in patients with a history of gastrointestinal ulcers or bleeding.
Monitor renal function in patients with pre-existing kidney conditions.
Use the lowest effective dose for the shortest duration necessary to minimize risk of adverse effects.

Interaction

Inflam-D Tablet 400 mg may interact with:

Other NSAIDs or anticoagulants, increasing the risk of bleeding.
Antihypertensive medications, potentially reducing their efficacy.
Diuretics, which may be less effective when used with dexibuprofen.

Disease Interaction

Inflam-D Tablet 400 mg should be used with caution in patients with:

Active or a history of gastrointestinal bleeding or ulcers.
Renal or hepatic impairment.
Cardiovascular disease, due to potential cardiovascular risks associated with NSAIDs.

Drug Interaction

Drug interactions include:

Increased risk of bleeding when used with anticoagulants like warfarin.
Reduced effectiveness of antihypertensive drugs like ACE inhibitors or angiotensin II receptor blockers.
Potential interactions with lithium, affecting its levels and efficacy.

Food Interactions

Taking dexibuprofen with food can help reduce gastrointestinal irritation. There are no significant food interactions reported.

Pregnancy Use

Inflam-D Tablet 400 mg is generally not recommended during pregnancy, particularly in the third trimester, due to potential risks to the fetus, such as cardiovascular effects and premature closure of the ductus arteriosus. Consult a healthcare provider for appropriate alternatives if needed during pregnancy.

Lactation Use

Inflam-D Tablet 400 mg is excreted in breast milk in small amounts. It is generally considered safe for use during lactation, but it's advisable to use the lowest effective dose and consult a healthcare provider.

Acute Overdose

Acute overdose can result in symptoms such as severe gastrointestinal distress, renal failure, and central nervous system effects like drowsiness or confusion. Management includes supportive care, maintaining hydration, and monitoring vital signs. Activated charcoal may be used if the overdose is recent.

Contraindication

Inflam-D Tablet 400 mg is contraindicated in:

Patients with known hypersensitivity to dexibuprofen or other NSAIDs.
Patients with active gastrointestinal bleeding or peptic ulcer disease.
Severe renal or hepatic impairment without medical supervision.

Use Direction

Follow the dosage instructions provided by your healthcare provider or as specified on the medication label. It is important to use dexibuprofen at the lowest effective dose for the shortest duration necessary to manage symptoms. Consult a healthcare provider if you have any concerns or experience adverse effects.

Storage Conditions

Store dexibuprofen at room temperature, away from moisture and direct sunlight. Keep the medication out of reach of children and follow any additional storage instructions provided on the packaging.

Volume of Distribution

The volume of distribution for dexibuprofen is approximately 0.1 to 0.2 L/kg, indicating that it is distributed throughout body tissues, including the central nervous system.

Half Life

The half-life of dexibuprofen is approximately 2 to 4 hours, which may vary depending on individual factors such as age, liver function, and dose.

Clearance

Inflam-D Tablet 400 mg is primarily cleared through the kidneys. The clearance rate can vary based on renal function and dosage, with adjustments necessary in patients with impaired renal function.

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