Scabo Tablet

Scabo Tablet 12 mg is a broad-spectrum anti-parasite medication. It was approved for the topical treatment of head lice infestations in patients 6 months of age and older. Scabo Tablet 12 mg is mainly used in humans in the treatment of onchocerciasis, but is also effective against other worm infestations (such as strongyloidiasis, ascariasis, trichuriasis and enterobiasis).

Scabo Tablet 12 mg is an anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis.

For the treatment of intestinal (i.e., nondisseminated) strongyloidiasis due to the nematode parasite Strongyloides stercoralis. Also for the treatment of onchocerciasis (river blindness) due to the nematode parasite Onchocerca volvulus. Can be used to treat scabies caused by Sarcoptes scabiei.

• Acne Rosacea
• Ascaris lumbricoides infection
• Cutaneous larva migrans
• Demodicidosis
• Gnathostomiasis
• Mansonella ozzardi infection
• Mansonella streptocerca infection
• Oesophagostomiasis
• Onchocerciasis
• Pediculosis Capitis
• Scabies
• Trichuriasis
• Wuchereria bancroftii infection

Scabo Tablet 12 mg is a semisynthetic, anthelminitic agent. It is an avermectin which a group of pentacyclic sixteen-membered lactone (i.e. a macrocyclic lactone disaccharide) derived from the soil bacterium Streptomyces avermitilis. Avermectins are potent anti-parasitic agents. Scabo Tablet 12 mg is the most common avermectin. It is a broad spectrum antiparasitic drug for oral administration. It is sometimes used to treat human onchocerciasis (river blindness). It is the mixture of 22,23-dihydro-avermectin B1a (at least 90%) and 22,23-dihydro-avermectin B1b (less than 10%).

Scabo Tablet 12 mg binds selectively and with high affinity to glutamate-gated chloride ion channels in invertebrate muscle and nerve cells of the microfilaria. This binding causes an increase in the permeability of the cell membrane to chloride ions and results in hyperpolarization of the cell, leading to paralysis and death of the parasite. Scabo Tablet 12 mg also is believed to act as an agonist of the neurotransmitter gamma-aminobutyric acid (GABA), thereby disrupting GABA-mediated central nervous system (CNS) neurosynaptic transmission. Scabo Tablet 12 mg may also impair normal intrauterine development of O. volvulus microfilariae and may inhibit their release from the uteri of gravid female worms.

Moderately well absorbed. Improved absorption with high fat meal.

The volume of distribution is 3 to 3.5 L/kg and it does not cross the blood-brain barrier.

93%

Scabo Tablet 12 mg is metabolized in the liver, and ivermectin and/or its metabolites are excreted almost exclusively in the feces over an estimated 12 days, with less than 1% of the administered dose excreted in the urine.

16 hours (also reported at 22-28 hours)

LD₅₀ = 29.5 mg/kg (Mouse, oral). LD₅₀ = 10 mg/kg (Rat, oral). Adverse effects include muscle or joint pain, dizziness, fever, headache, skin rash, fast heartbeat.

• Take on an empty stomach.