Introduction
Purisal Syrup 1 mg/5 ml is a β-agonist bronchodilator used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). It is a long-acting β-adrenergic agonist (LABA) that is an active isomer of albuterol, which belongs to a family of drugs called sympathomimetics. Purisal Syrup 1 mg/5 ml helps to relax the muscles in the airways, which helps widen the airways resulting in decreased airway obstruction.Uses
Purisal Syrup 1 mg/5 ml is used in the long-term management of asthma and COPD to improve air flow to the lungs. It is also used to prevent exercise-induced bronchospasm (EIB) in people with asthma, and to treat wheezing, shortness of breath, and other symptoms of airway obstruction in people with COPD.Mechanism of action
Purisal Syrup 1 mg/5 ml works by stimulating β-adrenergic receptors on airway smooth muscle. This causes relaxation of the airways and improved airflow.How long does it take to work?
Purisal Syrup 1 mg/5 ml begins to work within minutes of inhalation, with peak therapeutic effect at approximately 30 minutes.Absorption
The absorption of levalbutamol is rapid and the drug is completely absorbed within 10 minutes after inhalation.Route of elimination
Purisal Syrup 1 mg/5 ml is eliminated primarily through metabolic processes in the liver.Dosage
The recommended dose of levalbutamol is 200 mcg twice daily for adults and adolescents with asthma, and 500 mcg twice daily for adults and adolescents with COPD.
Administration
Purisal Syrup 1 mg/5 ml is available as an inhaler, and should be inhaled directly into the mouth, or with a spacer device.Side effects
The most common side effects of levalbutamol are headache, throat irritation, nausea, and dizziness.Toxicity
Acute overdose of levalbutamol can result in restlessness, palpitations, and increased blood pressure, heart rate, and respiratory rate.Precaution
Purisal Syrup 1 mg/5 ml should not be used in people with hypersensitivity to sympathomimetic amines, medical conditions such as severe cardiac arrhythmia, tachycardia, or hypertension, or people with hyperthyroidism or diabetes.Interaction
Purisal Syrup 1 mg/5 ml may interact with other medications. Tell your doctor all medications and supplements you are taking before using levalbutamol.Disease Interaction
Purisal Syrup 1 mg/5 ml may interact with certain conditions or diseases. Tell your doctor about any medical conditions you have before using levalbutamol.Drug Interactions
Purisal Syrup 1 mg/5 ml may interact with other medications. Tell your doctor all medications and supplements you are taking before using levalbutamol.Food Interactions
Purisal Syrup 1 mg/5 ml does not typically interact with foods. However, people with diabetes should monitor their blood sugar levels more closely while taking levalbutamol.Pregnancy Use
Purisal Syrup 1 mg/5 ml should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.Lactation Use
Purisal Syrup 1 mg/5 ml is excreted in human milk and should be used with caution in lactating women.Acute Overdose
Symptoms of acute overdose of levalbutamol include restlessness, palpitations, increased blood pressure, heart rate, and respiratory rate. Treatment should be supportive and symptomatic.Contraindication
Purisal Syrup 1 mg/5 ml should not be used in people with hypersensitivity to sympathomimetic amines, medical conditions such as severe cardiac arrhythmia, tachycardia, or hypertension, or people with hyperthyroidism or diabetes.Use Directions
Follow the directions for using levalbutamol exactly. Do not use it more often or use more of it than prescribed. Do not stop taking levalbutamol without talking to your doctor first.Storage Conditions
Store levalbutamol at room temperature, away from direct sunlight, moisture and heat.Volume of Distribution
The volume of distribution of levalbutamol is 3.2 L/kg.Half Life
The half-life of levalbutamol is approximately 3-4 hours.Clearance
The clearance of levalbutamol is approximately 4 mL/min/kg.See in details version Purisal Syrup 1 mg/5 ml also Purisal Syrup 1 mg/5 ml in bangla
Social card
Some Frequently Asked Questions About Purisal Syrup 1 mg/5 ml
1. What is Purisal Syrup 1 mg/5 ml?
Purisal Syrup 1 mg/5 ml (also called Levalbuterol) is a bronchodilator used to treat respiratory conditions like asthma and chronic obstructive pulmonary disease (COPD). It helps relax airway muscles and improve breathing.
2. How does Purisal Syrup 1 mg/5 ml work?
Purisal Syrup 1 mg/5 ml selectively stimulates beta-2 adrenergic receptors in the lungs, leading to smooth muscle relaxation and bronchodilation, which helps open up the airways.
3. What conditions is Purisal Syrup 1 mg/5 ml used to treat?
- Asthma
- Chronic obstructive pulmonary disease (COPD)
- Bronchospasm
- Exercise-induced bronchoconstriction
4. What forms does Purisal Syrup 1 mg/5 ml come in?
- Inhaler
- Nebulizer solution
- Tablet
- Syrup
5. How should Purisal Syrup 1 mg/5 ml be used?
Purisal Syrup 1 mg/5 ml is usually taken via inhalation using a nebulizer or inhaler. The dosage and frequency depend on the severity of the condition.
6. What is the usual dosage for adults?
- Inhaler: 90 mcg per puff, 1-2 puffs every 4-6 hours
- Nebulizer: 0.63 mg or 1.25 mg every 6-8 hours
7. Can Purisal Syrup 1 mg/5 ml be used in children?
Yes, it is prescribed for children, but the dosage is adjusted based on age and weight.
8. What is the difference between Purisal Syrup 1 mg/5 ml and Salbutamol?
Purisal Syrup 1 mg/5 ml is the active "R-enantiomer" of Salbutamol, which is believed to cause fewer side effects like tremors and palpitations while maintaining the same bronchodilation effect.
9. How quickly does Purisal Syrup 1 mg/5 ml work?
It starts working within 5-15 minutes, and its effects last for 4-6 hours.
10. Can Purisal Syrup 1 mg/5 ml be used for an acute asthma attack?
Yes, it is a fast-acting bronchodilator and is used for quick relief during asthma attacks.
11. Can Purisal Syrup 1 mg/5 ml be used for long-term asthma management?
It is mainly a rescue medication. Long-term management usually involves corticosteroids or other controller medications.
12. What are the common side effects of Purisal Syrup 1 mg/5 ml?
- Tremors
- Palpitations
- Nervousness
- Headache
- Dizziness
13. Can Purisal Syrup 1 mg/5 ml cause allergic reactions?
Yes, though rare, allergic reactions such as rashes, swelling, and difficulty breathing can occur.
14. Can Purisal Syrup 1 mg/5 ml cause high blood pressure?
It may cause a temporary increase in heart rate and blood pressure, but this is usually mild.
15. What should I do if I miss a dose?
Take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue your schedule.
16. Can I overdose on Purisal Syrup 1 mg/5 ml?
Yes, overdose symptoms include severe tremors, fast heartbeat, chest pain, and seizures. Seek immediate medical help in case of overdose.
17. Can Purisal Syrup 1 mg/5 ml be used for COPD?
Yes, it is often used to relieve symptoms of COPD, such as shortness of breath.
18. Can I use Purisal Syrup 1 mg/5 ml daily?
Yes, but frequent use may indicate poor asthma control, and your doctor may adjust your medication.
19. Can Purisal Syrup 1 mg/5 ml be used with steroids?
Yes, it is often combined with corticosteroids for better asthma and COPD management.
20. Can pregnant women take Purisal Syrup 1 mg/5 ml?
It is used if the benefits outweigh the risks. Consult your doctor before using it during pregnancy.
21. Can Purisal Syrup 1 mg/5 ml be used during breastfeeding?
It can pass into breast milk in small amounts, so consult your doctor before use.
22. Can Purisal Syrup 1 mg/5 ml cause insomnia?
Yes, since it stimulates the nervous system, it may cause trouble sleeping.
23. Is Purisal Syrup 1 mg/5 ml addictive?
No, but overuse can lead to reduced effectiveness over time.
24. Can I drink alcohol while using Purisal Syrup 1 mg/5 ml?
Alcohol may increase side effects like dizziness, so it is best to avoid it.
25. Can Purisal Syrup 1 mg/5 ml be taken with other asthma medications?
Yes, it is often used with inhaled steroids or other long-acting bronchodilators.
26. Can Purisal Syrup 1 mg/5 ml be used for exercise-induced asthma?
Yes, using an inhaler 15-30 minutes before exercise can help prevent asthma symptoms.
27. What should I do if Purisal Syrup 1 mg/5 ml doesn’t work?
Seek medical attention if symptoms persist despite using the prescribed dose.
28. Can Purisal Syrup 1 mg/5 ml be used in nebulizers?
Yes, it is available as a nebulizing solution for inhalation therapy.
29. Does Purisal Syrup 1 mg/5 ml cause weight gain?
No, it does not cause weight gain.
30. Can Purisal Syrup 1 mg/5 ml affect blood sugar levels?
Yes, it may cause temporary increases in blood sugar, especially in diabetics.
31. How should Purisal Syrup 1 mg/5 ml be stored?
Keep it at room temperature, away from moisture and heat.
32. Does Purisal Syrup 1 mg/5 ml interact with beta-blockers?
Yes, beta-blockers like propranolol may reduce its effectiveness.
33. Can children use Purisal Syrup 1 mg/5 ml syrup?
Yes, syrup form is prescribed for young children under a doctor's supervision.
34. How often can I use a Purisal Syrup 1 mg/5 ml inhaler?
Usually every 4-6 hours as needed, but do not exceed the prescribed dose.
35. Can Purisal Syrup 1 mg/5 ml cause chest pain?
Rarely, but if chest pain occurs, seek medical attention immediately.
36. Is Purisal Syrup 1 mg/5 ml a steroid?
No, it is a bronchodilator, not a steroid.
37. Can I use Purisal Syrup 1 mg/5 ml with antibiotics?
Yes, but inform your doctor about all medications you are taking.
38. Can Purisal Syrup 1 mg/5 ml be used for cough?
It is used if the cough is due to bronchospasm.
39. Can Purisal Syrup 1 mg/5 ml be used in heart patients?
Caution is needed as it can increase heart rate.
40. What happens if I stop using Purisal Syrup 1 mg/5 ml suddenly?
Stopping suddenly does not cause withdrawal, but symptoms may return.
41. Can I drive after using Purisal Syrup 1 mg/5 ml?
Yes, unless you experience dizziness or tremors.
42. Can Purisal Syrup 1 mg/5 ml be used for pneumonia?
It may help in pneumonia with bronchospasm but does not treat the infection.
43. Can I take Purisal Syrup 1 mg/5 ml with antihistamines?
Yes, but consult your doctor.
44. Can Purisal Syrup 1 mg/5 ml cause dehydration?
No, but drink plenty of fluids to avoid dry mouth.
45. Is Purisal Syrup 1 mg/5 ml available over-the-counter?
No, it requires a prescription.
46. Can it be used in smokers?
Yes, but smoking worsens lung conditions.
47. Can it cause dizziness?
Yes, dizziness is a common side effect.
48. Can Purisal Syrup 1 mg/5 ml be used in emergencies?
Yes, for acute bronchospasm.
49. Can Purisal Syrup 1 mg/5 ml be used long-term?
It is mainly for short-term relief.
50. Can it be used for allergies?
Only if allergies cause bronchospasm.
