Palorid Tablet

Introduction

Palorid Tablet 1 mg is an orally available prokinetic agent prescribed for treating chronic constipation, indigestion, and other intestinal disorders. It works by stimulating the movement of the intestines, thereby increasing the speed at which food passes through the digestive tract.

Uses for

Palorid Tablet 1 mg is primarily prescribed to treat chronic constipation, indigestion, and other intestinal disorders, including:

Lack of bowel movements
Difficulty in defecating
Stool hardening or retaining liquid

Brand Name	Palorid
Type	Tablet
Weight	1 mg
Generic	Prucalopride Succinate
Manufacturer	One Pharma Ltd.
Available in	English বাংলা

Mechanism of Action

Palorid Tablet 1 mg affects several different aspects of the gastrointestinal tract. It increases the activity of enzymes located on the walls of the intestines, which helps to speed up intestinal motility. This increases the rate at which food material is moved through the digestive tract. This reduces the amount of time it takes to move food through the system and encourages the bowels to work more efficiently.

How Long Does it Take to Work?

The effects of taking Palorid Tablet 1 mg typically begin within 1 hour after taking the first dose. However, it may take up to 4 weeks for the full benefit from the medication to be seen. Most people experience constipation relief within 24 hours of the start of treatment.

Absorption

Palorid Tablet 1 mg is quickly and almost completely absorbed from the intestine after oral administration. Its overall bioavailability is around 65%.

Route of Elimination

Palorid Tablet 1 mg is metabolized in the liver and circulated in the blood. It is then eliminated through the kidney and gastrointestinal tract. These routes of elimination are referred to as renal excretion and biliary excretion, respectively.

Dosage

Adults: 2 mg once daily with or without food, at any time of the day. Due to the specific mode of action of prucalopride (stimulation of propulsive motility), exceeding the daily dose of 2 mg is not expected to increase efficacy.

Older people: Start with 1 mg once daily; if needed the dose can be increased to 2 mg once daily.

Children: Prucalopride should not be used in children and adolescents younger than 18 years

The recommended starting dose of Palorid Tablet 1 mg is 0.5 mg daily, taken with or without food. The maximum dose is 2 mg per day. Patients can increase the dose by 0.5 mg increments once a week until the desired effect is achieved. In case of missed dose or overdose, it is important to contact a doctor immediately.

Administration

Palorid Tablet 1 mg is usually taken orally. The tablets should be swallowed whole with a glass of water and should not be chewed or broken in half. It is important to take Palorid Tablet 1 mg at the same time each day to maintain an even level in the body.

Side Effect

Common side effects of Palorid Tablet 1 mg include:

Diarrhea
Nausea
Abdominal cramping
Headache
Fatigue

Toxicity

Palorid Tablet 1 mg has a low risk of toxicity due to its limited absorption and rapid elimination from the body. It is generally considered safe and well tolerated.

Precautions

Patients should inform their doctor of any changes in condition such as increased or decreased bowel movements, constipation, nausea, vomiting, and abdominal pain. It is also important to tell the physician about any medications, vitamins, or supplements being taken concurrently, as well as any underlying medical conditions.

Interactions

Palorid Tablet 1 mg may interact with other medications including:

Digoxin (Lanoxin)
Antidepressants
Anti-anxiety medications
Birth control pills

Disease Interaction

Palorid Tablet 1 mg may interact with certain conditions such as:

Depression
Diabetes
Thyroid disorders
High blood pressure

Drug Interaction

The following drugs could interact with Palorid Tablet 1 mg:

Cimetidine (Tagamet)
Omeprazole (Prilosec)
Ranolazine (Ranexa)
Carbamazepine (Tegretol)

Food Interactions

Alcohol and foods rich in fiber, including fruits and vegetables, may interact with Palorid Tablet 1 mg. It is important to discuss any dietary changes with a physician before taking the medication.

Pregnancy Use

Palorid Tablet 1 mg is not recommended for use in pregnant women. Women who are planning to become pregnant, are pregnant, or are breastfeeding should inform their doctor.

Lactation Use

Palorid Tablet 1 mg is not recommended for use in breastfeeding women. Women who are breastfeeding should inform their doctor.

Acute Overdose

It is important to seek immediate medical attention if an overdose of Palorid Tablet 1 mg is suspected. Symptoms of an overdose include nausea, vomiting, abdominal pain, and diarrhea.

Contraindication

Palorid Tablet 1 mg is contraindicated in patients with known hypersensitivity to the drug. It is also contraindicated in patients who have a history of kidney or liver disease.

Use Direction

The medication should be taken at the same time each day, preferably in the morning and at bedtime. It is important to take Pricalopride Succinate as directed by the doctor and not to skip any doses. The tablets should be swallowed whole with a glass of water and should not be chewed or broken in half.

Storage Condition

Palorid Tablet 1 mg should be stored at room temperature, away from excess heat and moisture. It should be stored in a tight closed container and away from pets and children.

Volume of Distribution

The volume of distribution of Palorid Tablet 1 mg is about 0.16 L/kg. This means that the drug is mostly distributed throughout the body's tissues and organs, and not concentrated in the blood.

Half Life

The half-life of Palorid Tablet 1 mg is 4-8 hours. This means that it takes 4-8 hours for the body to reduce the drug concentration in the blood by half.

Clearance

Palorid Tablet 1 mg is primarily eliminated from the body through renal excretion (14%) and biliary excretion (71%). It is also metabolized in the liver and eliminated through this route (15%). The clearance of Palorid Tablet 1 mg is 1.51 ml/min/kg.

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