Introduction
A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
Uses
Mefalgin Oral Suspension 50 mg/5 ml is an NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea.
For the treatment of rheumatoid arthritis, osteoarthritis, dysmenorrhea, and mild to moderate pain, inflammation, and fever.
Associated Conditions
Pharmacodynamics
Mefalgin Oral Suspension 50 mg/5 ml, an anthranilic acid derivative, is a member of the fenamate group of nonsteroidal anti-inflammatory drugs (NSAIDs). It exhibits anti-inflammatory, analgesic, and antipyretic activities. Similar to other NSAIDs, mefenamic acid inhibits prostaglandin synthetase.
Mechanism of Action
Mefalgin Oral Suspension 50 mg/5 ml binds the prostaglandin synthetase receptors COX-1 and COX-2, inhibiting the action of prostaglandin synthetase. As these receptors have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity, the symptoms of pain are temporarily reduced.
Absorption
Mefalgin Oral Suspension 50 mg/5 ml is rapidly absorbed after oral administration.
Volume of Distribution
- 1.06 L/kg [Normal Healthy Adults (18-45 yr)]
Protein Binding
90%
Route of Elimination
The fecal route of elimination accounts for up to 20% of the dose, mainly in the form of unconjugated 3-carboxymefenamic acid.3 The elimination half-life of mefenamic acid is approximately two hours. Mefalgin Oral Suspension 50 mg/5 ml, its metabolites and conjugates are primarily excreted by the kidneys. Both renal and hepatic excretion are significant pathways of elimination.
Half Life
2 hours
Clearance
- Oral cl=21.23 L/hr [Healthy adults (18-45 yrs)]
Toxicity
Oral, rat LD50: 740 mg/kg. Symptoms of overdose may include severe stomach pain, coffee ground-like vomit, dark stool, ringing in the ears, change in amount of urine, unusually fast or slow heartbeat, muscle weakness, slow or shallow breathing, confusion, severe headache or loss of consciousness.
Food Interactions
- Avoid alcohol.
- Take with food.
