Introduction
Kilpan Tablet 10 mg or “Ketorolac” is a NSAID (nonsteroidal anti-inflammatory drug) used to treat short term pain. It is a prescription medication and acts to reduce hormones that cause inflammation and pain in the body. It can be used to treat pain from a variety of causes such as muscle aches, dental pain, period pain, back pain, migraine headache, and post-surgery pain.Uses
Ketorolac is used as a short-term treatment for moderate to severe pain. It can be used to treat pain from sprains, strains, headache, migraine, menstrual cramps, muscle spasms, and pain after surgery, dental work, or an injury. It can also be used to treat inflammation and swelling caused by conditions such as osteoarthritis, rheumatoid arthritis, and gout.| Brand Name | Kilpan |
|---|---|
| Type | Tablet |
| Weight | 10 mg |
| Generic | Ketorolac Tromethamine |
| Manufacturer | Decent Pharma Laboratories Ltd. |
| Available in | English বাংলা |
Mechanism of Action
Ketorolac works by blocking the production of prostaglandins. Prostaglandins are hormones that signal pain and inflammation to the brain. When they are blocked, pain relief is achieved.How Long Does it Take to Work?
Ketorolac typically starts to work within 1 hour of taking it and can provide up to 4 to 6 hours of relief. However, this may vary depending on the individual, the condition, and the dosage.Absorption
Ketorolac is well absorbed from the stomach and small intestine. It is lipid mode of transport and does not rely on active transportRoute of Elimination
Ketorolac is metabolized in the liver and excreted through the kidneys. It can also be excreted in the saliva and sweat.Dosage
Tablet: Recommended dose is 10 mg every 4-6 hours. It should be used short-term only (up to 7 days) and are not recommended for chronic use. Doses exceeding 40 mg/day is not recommended.
Injection: Ketorolac injection may be used as a single or multiple doses, on a regular or when necessary schedule for the management of moderately severe, acute pain that requires analgesia at the opioid level, usually in a postoperative setting. When administering Ketorolac injection, the IV bolus must be given over no less than 15 seconds. The IM administration should be given slowly and deeply into the muscle. The analgesic effect begins within 30 minutes with maximum effect in 1 to 2 hours after dosing IV or IM. Duration of analgesic effect is usually 4 to 6 hours.
IM Dosing (Adult):
- Patients <65 years of age: One dose of 60 mg.
- Patients >65 years of age, renally impaired and/or less than 50 kg of body weight: One dose of 30 mg.
- Patients <65 years of age: One dose of 30 mg.
- Patients >65 years of age, renally impaired and/or less than 50 kg of body weight: One dose of 15 mg.
- IM Dosing: One dose of 1 mg/kg up to a maximum of 30 mg.
- IV Dosing: One dose of 0.5 mg/kg up to a maximum of 15 mg.
- Patients <65 years of age: The recommended dose is 30 mg Ketorolac injection every 6 hours. The maximum daily dose should not exceed 120 mg. Patients >65 years of age, renally impaired patients and patients less than 50 kg: The recommended dose is 15 mg Ketorolac injection every 6 hours. The maximum daily dose for these populations should not exceed 60 mg. For breakthrough pain, do not increase the dose or the frequency of Ketorolac Tromethamine.
- Conversion from Parenteral to Oral Therapy: Ketorolac tablets may be used either as monotherapy or as follow-on therapy to parenteral Ketorolac. When Ketorolac tablets are used as a follow-on therapy to parenteral Ketorolac, the total combined daily dose of ketorolac (oral + parenteral) should not exceed 120 mg in younger adult patients or 60 mg in elderly patients on the day the change of formulation is made. On subsequent days, oral dosing should not exceed the recommended daily maximum of 40 mg. Ketorolac IM should be replaced by Ketorolac tablet as soon as feasible. The total duration of combined parenteral and oral treatment should not exceed 5 days.
Administration
Ketorolac can be taken by mouth as an oral tablet, solution, or injection. It can also be taken rectally (as an enema), intravenously (through a vein), or as a transdermal patch.Side Effects
Common side effects of taking ketorolac include nausea, vomiting, drowsiness, dizziness, headache, and constipation. It can also cause stomach pain, stomach ulcers, and internal bleeding. More serious side effects include kidney or liver damage, low blood pressure, and an increase in cholesterol or triglycerides.Toxicity
Ketorolac is considered to be safe when taken in the recommended dosages and for short-term pain relief. Overdose of ketorolac can cause serious adverse reactions such as seizures or coma.Precautions
Ketorolac should only be taken as prescribed by a physician. It should not be taken for longer than 5 days. It should not be taken with alcohol or other drugs, as this can increase the risk of serious side effects.Interactions
Ketorolac may interact with certain other medications such as warfarin, lithium, cyclosporine, and methotrexate. It can also interact with certain supplements and herbal products.Drug Interactions
Ketorolac may interact with certain other drugs such as aspirin, ibuprofen, naproxen, celecoxib, and sulfa drugs. It can also interact with certain anticoagulants such as warfarin, fluoxetine or SSRI, and steroids such as prednisone.Food Interactions
Ketorolac should be taken with a full glass of water. It should be taken with food or milk, if possible, to decrease the risk of stomach upset.Pregnancy Use
Ketorolac should not be taken during pregnancy, as it may cause problems during the pregnancy or delivery.Lactation Use
Ketorolac should not be used while breastfeeding as it can pass into breast milk and affect the baby.Acute Overdose
Acute overdose of ketorolac can cause serious side effects such as seizures, slow heart rate, breathing problems, or coma.Contraindication
Ketorolac should not be taken by people with peptic ulcer, asthma, bleeding disorders, impaired kidney or liver function, or who take other medications such as aspirin, blood thinners, oral contraceptives, or steroids.Use Direction
Ketorolac should be taken as prescribed by a physician. The dose and frequency of use will vary depending on the individual and the condition it is being used to treat.Storage Condition
Ketorolac should be stored at room temperature, away from heat and moisture.Volume of Distribution
Ketorolac has a volume of distribution of 140 liters/kg.Half Life
The half-life of ketorolac is 6-9 hours.Clearance
Ketorolac is cleared by the kidneys. The clearance time is 7-11 hours.See in details version Kilpan Tablet 10 mg also Kilpan Tablet 10 mg in bangla
Some Frequently Asked Questions About Kilpan Tablet 10 mg
1. What is Kilpan Tablet 10 mg?
Kilpan Tablet 10 mg is a nonsteroidal anti-inflammatory drug (NSAID) used for short-term management of moderate to severe pain.
2. How does Kilpan Tablet 10 mg work?
It inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin production, which helps decrease pain, inflammation, and fever.
3. What is Kilpan Tablet 10 mg used for?
It is commonly used for postoperative pain, musculoskeletal pain, and pain due to kidney stones.
4. Is Kilpan Tablet 10 mg a narcotic?
No, it is not an opioid and does not cause dependence.
5. How is Kilpan Tablet 10 mg administered?
It is available in oral tablets, injections (IV/IM), and ophthalmic (eye drop) forms.
6. Can I take Kilpan Tablet 10 mg for headaches?
It is not typically used for headaches or migraines due to potential gastrointestinal risks.
7. How long does it take for Kilpan Tablet 10 mg to work?
It starts working within 30-60 minutes, with peak effects in 2-3 hours.
8. How long can I take Kilpan Tablet 10 mg?
It should not be used for more than 5 days due to the risk of serious side effects.
9. Can Kilpan Tablet 10 mg cause drowsiness?
Yes, it may cause drowsiness, dizziness, or fatigue.
10. Can I drive after taking Kilpan Tablet 10 mg?
Avoid driving if you experience dizziness or drowsiness.
11. What are the common side effects of Kilpan Tablet 10 mg?
Nausea, indigestion, stomach pain, dizziness, and headache are common side effects.
12. What are the serious side effects?
Serious effects include gastrointestinal bleeding, kidney damage, liver toxicity, and allergic reactions.
13. Can Kilpan Tablet 10 mg cause stomach ulcers?
Yes, prolonged use can lead to stomach ulcers and bleeding.
14. Can I take Kilpan Tablet 10 mg on an empty stomach?
No, take it with food or milk to reduce stomach irritation.
15. Can Kilpan Tablet 10 mg raise blood pressure?
Yes, NSAIDs can cause fluid retention, leading to increased blood pressure.
16. Can Kilpan Tablet 10 mg be taken with other NSAIDs?
No, taking multiple NSAIDs increases the risk of side effects.
17. Can I drink alcohol while taking Kilpan Tablet 10 mg?
No, alcohol increases the risk of stomach ulcers and bleeding.
18. Is Kilpan Tablet 10 mg safe during pregnancy?
It is not recommended, especially in the third trimester.
19. Can breastfeeding mothers take Kilpan Tablet 10 mg?
It passes into breast milk in small amounts; consult your doctor before use.
20. Can I take Kilpan Tablet 10 mg with blood thinners?
No, it increases the risk of bleeding.
21. Can Kilpan Tablet 10 mg cause kidney problems?
Yes, prolonged use can cause kidney damage or failure.
22. What should I do if I miss a dose?
Take it as soon as possible, but do not double the dose.
23. What happens if I overdose on Kilpan Tablet 10 mg?
Overdose can cause severe stomach bleeding, kidney failure, or breathing issues. Seek immediate medical attention.
24. How is Kilpan Tablet 10 mg different from ibuprofen?
Ketorolac is stronger and only recommended for short-term use, while ibuprofen is available over-the-counter and safer for long-term use.
25. Can children take Kilpan Tablet 10 mg?
It is generally not recommended for children unless prescribed by a doctor.
26. How should Kilpan Tablet 10 mg be stored?
Store at room temperature, away from moisture and heat.
27. Does Kilpan Tablet 10 mg affect liver function?
It can cause liver enzyme elevation and, in rare cases, liver damage.
28. Is Kilpan Tablet 10 mg available over the counter?
No, it requires a prescription.
29. Can I take Kilpan Tablet 10 mg for menstrual cramps?
It is not typically used for menstrual pain due to its risk of side effects.
30. Can diabetics take Kilpan Tablet 10 mg?
Use caution as it may affect kidney function.
31. What is the usual dosage for Kilpan Tablet 10 mg?
Oral: 10 mg every 4-6 hours (max 40 mg/day); IM/IV: 30-60 mg initially, then 15-30 mg every 6 hours.
32. Can I take Kilpan Tablet 10 mg for arthritis?
It is not recommended for chronic conditions like arthritis.
33. Can Kilpan Tablet 10 mg be used post-surgery?
Yes, it is commonly used for post-operative pain relief.
34. Can Kilpan Tablet 10 mg cause weight gain?
Weight gain due to fluid retention is possible.
35. Can Kilpan Tablet 10 mg cause depression?
It is not directly linked, but mood changes can occur as a side effect.
36. Is Kilpan Tablet 10 mg safe for elderly patients?
Use with caution due to increased risk of kidney issues and stomach bleeding.
37. Can I take Kilpan Tablet 10 mg with aspirin?
No, it increases the risk of bleeding and stomach issues.
38. Can Kilpan Tablet 10 mg affect vision?
Blurred vision or eye irritation can occur, especially with the ophthalmic form.
39. Can I take Kilpan Tablet 10 mg for back pain?
Yes, but only for short-term use.
40. Can I take Kilpan Tablet 10 mg for gout?
It can relieve gout pain, but it is not a primary treatment.
41. Can Kilpan Tablet 10 mg cause shortness of breath?
Yes, rare cases of allergic reactions or lung issues can occur.
42. Does Kilpan Tablet 10 mg increase bleeding risk?
Yes, it affects platelet function and increases bleeding risk.
43. Can I stop taking Kilpan Tablet 10 mg suddenly?
Yes, but consult your doctor if stopping after prolonged use.
44. Can Kilpan Tablet 10 mg cause constipation?
Yes, digestive side effects like constipation or diarrhea can occur.
45. Can Kilpan Tablet 10 mg affect hearing?
Rare cases of ringing in the ears (tinnitus) have been reported.
46. What should I do if I have an allergic reaction?
Seek emergency medical help if you experience swelling, rash, or difficulty breathing.
47. Can I take Kilpan Tablet 10 mg for cancer pain?
It is not commonly used for cancer pain management.
48. Can I take Kilpan Tablet 10 mg with antidepressants?
Some antidepressants increase bleeding risk; consult your doctor.
49. Can I take Kilpan Tablet 10 mg if I have asthma?
NSAIDs can trigger asthma symptoms; use with caution.
50. Can I take Kilpan Tablet 10 mg for dental pain?
Yes, it is sometimes prescribed after dental procedures.
Dr. Jebun Nahar
Newborn, Adolescent, Child Diseases & Development Specialist
Child Specialist Doctor in Dhaka
Prof. Dr. Col. Quazi Salim Yazdi
Skin, Allergy, Leprosy & Sexual Diseases Specialist
Dermatology Doctor in Jhalokati
