Glucolin DS IV Infusion 10% 10% Uses, Dosage, Side Effects & Price - গ্লুকোলিন ডিএস আইভি ইনফিউশন

Name: Glucolin DS IV Infusion 10%
Brand: Glucolin DS
SKU: glucolin-ds-iv-infusion-10-
Price: 50078.2 BDT
Availability: OnlineOnly

Brand Name	Glucolin DS
Type	IV Infusion
Weight	10%
Generic	Dextrose
Manufacturer	Popular Pharmaceuticals Ltd.
Price	500 ml bag: ৳ 78.20

Brand Name

Glucolin DS

Type

IV Infusion

Weight

10%

Generic

Dextrose

Manufacturer

Popular Pharmaceuticals Ltd.

Price

500 ml bag: ৳ 78.20

About Glucolin DS

Glucolin DS IV Infusion (Popular Pharmaceuticals Ltd.) is a brand medicine containing the generic Dextrose . Current listed price in Bangladesh: 500 ml bag: ৳ 78.20.

Introduction

Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants. It is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms (glycogenolysis). It circulates in human circulation as blood glucose and acts as an essential energy source for many organisms through aerobic or anaerobic respiration and fermentation. It is primarily stored as starch in plants and glycogen in animals to be used in various metabolic processes in the cellular level. Its aldohexose stereoisomer, dextrose or D-glucose, is the most commonly occurring isomer of glucose in nature. L-glucose is a synthesized enantiomer that is used as a low-calorie sweetener and laxative. The unspecified form of glucose is commonly supplied as an injection for nutritional supplementation or metabolic disorders where glucose levels are improperly regulated. Glucose is listed on the World Health Organization's List of Essential Medicines.

Uses

Glucose is a form of glucose used for caloric supply and the replenishment of fluid in total parenteral nutrition and other therapies as well as for the treatment of hypoglycemic episodes.

Glucose pharmaceutical formulations (oral tablets, injections) are indicated for caloric supply and carbohydrate supplementation in case of nutrient deprivation. It is also used in metabolic disorders such as hypoglycemia.

Associated Conditions

Arrhythmia
Caloric Deficit
Edema of the cerebrum
Metabolic Alkalosis
Hypoglycemic reaction
Blood Specimen Collection
Electrolyte replacement
Nutritional supplementation
Parenteral Nutrition
Parenteral rehydration therapy
Plasmapheresis
Positive cardiac inotropic effect
Total parenteral nutrition therapy
Urine alkalinization therapy
Fluid and electrolyte maintenance therapy

Pharmacodynamics

Blood glucose is an obligatory energy source in humans involved in various cellular activities, and it also acts as a signalling molecule for diverse glucose-sensing molecules and proteins. Glucose undergoes oxidation into carbon dioxide, water and yields energy molecules in the process of glycolysis and subsequent citric cycle and oxidative phosphorylation. Glucose is readily converted into fat in the body which can be used as a source of energy as required. Under a similar conversion into storage of energy, glucose is stored in the liver and muscles as glycogen. Glucose stores are mobilized in a regulated manner, depending on the tissues' metabolic demands. Oral glucose tablets or injections serve to increase the supply of glucose and oral glucose administration is more effective in stimulating insulin secretion because it stimulates the incretin hormones from the gut, which promotes insulin secretion.

Mechanism of Action

Glucose supplies most of the energy to all tissues by generating energy molecules ATP and NADH during a series of metabolism reactions called glycolysis. Glycolysis can be divided into 2 main phases where the preparatory phase is initiated by the phosphorylation of glucose by a hexokinase to form glucose 6-phosphate. The addition of the high-energy phosphate group activates glucose for subsequent breakdown in later steps of glycolysis and is the rate-limiting step. Products end up as substrates for following reactions, to ultimately convert C6 glucose molecule into two C3 sugar molecules. These products enter the energy-releasing phase where total of 4ATP and 2NADH molecules are generated per one glucose molecule. The total aerobic metabolism of glucose can produce up to 36 ATP molecules. This energy-producing reactions of glucose is limited to D-glucose as L-glucose cannot be phosphorlyated by hexokinase. Glucose can act as precursors to generate other biomolecules such as vitamin C. It plays a role as a signaling molecule to control glucose and energy homeostasis. Glucose can regulate gene transcription, enzyme activity, hormone secretion, and the activity of glucoregulatory neurons. The types, number and kinetics of glucose transporters expressed depends on the tissues and fine-tunes glucose uptake, metabolism, and signal generation in order to preserve cellular and whole body metabolic integrity .

Absorption

Polysaccharides can be broken down into smaller units by pancreatic and intestinal glycosidases or intestinal flora. Sodium-dependent glucose transporter SGLT1 and GLUT2 (SLC2A2) play predominant roles in intestinal transport of glucose into the circulation. SGLT1 is located in the apical membrane of the intestinal wall while GLUT2 is located in the basolateral membrane, but it was proposed that GLUT2 can be recruited into the apical membrane after a high luminal glucose bolus allowing bulk absorption of glucose by facilitated diffusion . Oral preparation of glucose reaches the peak concentration within 40 minutes and the intravenous infusions display 100% bioavailability.

Volume of Distribution

The mean volume of distribution after intravenous infusion is 10.6L.

Route of Elimination

Glucose can be renally excreted.

Half Life

The approximate half-life is 14.3 minutes following intravenous infusion. Gut glucose half-life was markedly higher in females (79 ± 2 min) than in males (65 ± 3 min, P < 0.0001) and negatively related to body height (r = -0.481; P < 0.0001).

Clearance

The mean metabolic clearance rate of glucose (MCR) for the 10 subjects studied at the higher insulin level was 2.27 ± 0.37 ml/kg/min at euglycemia and fell to 1.51±0.21 ml/kg/ at hyperglycemia. The mean MCR for the six subjects studied at the lower insulin level was 1.91 ± 0.31 ml/kg/min at euglyglycemia.

Toxicity

Oral LD50 value in rats is 25800mg/kg. The administration of glucose infusions can cause fluid and/or solute overloading resulting in dilution of the serum electrolyte concentrations, over-hydration, congested states, or pulmonary oedema. Hypersensitivity reactions may also occur including anaphylactic/anaphylactoid reactions from oral tablets and intravenous infusions.

Food Interactions

No interactions found.

Dosage

5% dextrose solution: The dose of Glucolin DS IV Infusion 10% infusion is variable. It is dependent on individual patient requirements. For 5% dextrose solution, the dose frequently ranges from 500 to 1000 ml. The maximum rate of infusion that will not cause glycosuria is 0.5 g/kg/hour. About 95% is retained when the rate is 0.8 g/kg/hr. the maximum rate of glucose utilization is about 800 mg per kg body weight per hour.

10% dextrose solution: Dose is variable. It depends on the clinical condition, age and body surface area of the patients and the judgment of the physician. Ordinarily, normal circulation is restored by infusing 20-30 ml/kg as rapidly as possible. The laboratory findings should be available by this time so that the physician can proceed more slowly with logically planned subsequent fluid therapy.

25% dextrose solution: The volume and rate of infusion of dextrose solution will depend upon the requirements of the individual patient and the judgment of the physician. The maximum rate at which dextrose can be infused without producing glycosuria is 0.5 g/kg/hr. The usual recommended flow rate for adult is 10-35 drops per minute infused intravenously. It should not be administered by SC or IM route. 25% dextrose solution should be infused through the largest available peripheral vein.

Oral powder:

Adult: 10-20 gm as single dose; may repeat in 10 min if needed.
Child: >2 yr: 10-20 gm as single dose; may repeat in 10 min if needed.

Frequently Asked Questions About Glucolin DS IV Infusion 10%

1. What is Glucolin DS IV Infusion 10% used for as a human drug?

Glucolin DS IV Infusion 10% is a form of glucose, which is a type of sugar. It is used primarily for treating low blood sugar (hypoglycemia), dehydration, and providing a source of energy during parenteral nutrition (IV fluids). It is also used to treat conditions like diabetic ketoacidosis, as it can raise blood sugar levels quickly.

2. How is Glucolin DS IV Infusion 10% administered to patients?

Glucolin DS IV Infusion 10% can be administered intravenously (IV) in the form of a solution or as an oral gel in certain cases. The method of administration depends on the patient's condition and the severity of the symptoms.

3. Can Glucolin DS IV Infusion 10% be given to diabetic patients?

Glucolin DS IV Infusion 10% is used cautiously in diabetic patients, especially those with type 1 or type 2 diabetes, because it can raise blood glucose levels. It may be given in controlled amounts to treat severe hypoglycemia or to provide an energy source, but blood glucose levels need to be monitored closely.

4. What are the side effects of Glucolin DS IV Infusion 10%?

Some possible side effects of Glucolin DS IV Infusion 10% include hyperglycemia (high blood sugar), fluid overload, electrolyte imbalances, and vein irritation if the IV is not properly administered. Long-term use may lead to complications like insulin resistance or weight gain.

5. How does Glucolin DS IV Infusion 10% work in the body?

Glucolin DS IV Infusion 10% is rapidly absorbed into the bloodstream, where it increases blood sugar levels. It provides a quick source of energy for cells, especially for those in the brain and muscles. This makes it an essential treatment for hypoglycemia and energy depletion.

6. Can Glucolin DS IV Infusion 10% be used in emergency situations?

Yes, Glucolin DS IV Infusion 10% is commonly used in emergency situations to treat hypoglycemia or low blood sugar, especially in unconscious or severely ill patients. It is often administered intravenously in these cases for rapid absorption.

7. What concentration of Glucolin DS IV Infusion 10% is typically used in IV fluids?

Glucolin DS IV Infusion 10% is commonly used in concentrations ranging from 5% to 50% in intravenous solutions. The specific concentration depends on the patient's needs and the severity of the condition being treated. A 5% Glucolin DS IV Infusion 10% solution is often used for hydration, while higher concentrations are used for more urgent treatments like hypoglycemia.

8. Can Glucolin DS IV Infusion 10% be used to treat dehydration?

Yes, Glucolin DS IV Infusion 10% is used in combination with saline or other electrolytes in IV solutions to treat dehydration. It helps restore fluids and energy to the body, especially in cases of fluid loss due to illness, vomiting, or diarrhea.

9. Is Glucolin DS IV Infusion 10% safe for long-term use?

While Glucolin DS IV Infusion 10% is generally safe when used for short-term treatment of conditions like hypoglycemia, prolonged use or excessive amounts can lead to hyperglycemia, weight gain, and insulin resistance. It is important to use it under medical supervision.

10. Can Glucolin DS IV Infusion 10% cause weight gain?

Yes, prolonged or excessive use of Glucolin DS IV Infusion 10% can lead to weight gain, especially if the body consistently absorbs more glucose than it can use. This can increase fat stores and contribute to insulin resistance over time.

11. Is Glucolin DS IV Infusion 10% safe during pregnancy?

Glucolin DS IV Infusion 10% is generally considered safe during pregnancy, especially when used to treat hypoglycemia or dehydration. However, like any medication, it should be used under the supervision of a healthcare provider to avoid complications like hyperglycemia or excessive fluid retention.

12. Can Glucolin DS IV Infusion 10% be used in newborns?

Glucolin DS IV Infusion 10% is commonly used in newborns, especially in cases of neonatal hypoglycemia or when infants are unable to feed. The solution is usually given intravenously and in carefully controlled amounts to avoid complications such as hyperglycemia.

13. How is Glucolin DS IV Infusion 10% different from other types of glucose?

Glucolin DS IV Infusion 10% is a form of glucose that is chemically identical to the sugar found in the human bloodstream. Unlike other forms of glucose, it is more quickly absorbed by the body and provides immediate energy, which is why it is used in emergencies and intravenous solutions.

14. Can Glucolin DS IV Infusion 10% be used for weight loss?

Glucolin DS IV Infusion 10% is not recommended for weight loss. It is a sugar that provides energy, which may contribute to weight gain if not used efficiently by the body. For weight loss, a balanced diet and regular exercise are typically recommended.

15. How does Glucolin DS IV Infusion 10% affect blood sugar levels?

Glucolin DS IV Infusion 10% rapidly increases blood sugar levels upon entering the bloodstream. It is used to treat hypoglycemia by raising blood sugar levels to normal ranges. However, in individuals with diabetes, it can cause a significant rise in blood glucose levels.

16. What should I do if I experience side effects from Glucolin DS IV Infusion 10%?

If you experience any side effects from Glucolin DS IV Infusion 10%, such as signs of hyperglycemia (excessive thirst, frequent urination, fatigue), contact your healthcare provider immediately. They may need to adjust your treatment plan or monitor your blood sugar levels more closely.

17. Can Glucolin DS IV Infusion 10% be used for energy during exercise?

Glucolin DS IV Infusion 10% can be used as a quick source of energy during exercise. It is absorbed rapidly by the body and can replenish energy stores in muscles during intense physical activity. However, it should be used in moderation to avoid blood sugar spikes.

18. Is Glucolin DS IV Infusion 10% the same as sugar?

Yes, Glucolin DS IV Infusion 10% is a form of glucose, which is the same type of sugar that the body uses for energy. It is often referred to as “blood sugar” because it is the primary sugar found in the bloodstream.

19. Can Glucolin DS IV Infusion 10% be used for burns?

Glucolin DS IV Infusion 10% is not used topically for burns, but it may be part of a patient's IV fluid regimen if they are dehydrated due to burn injuries. The goal is to restore fluids and energy to the body.

20. Can Glucolin DS IV Infusion 10% cause high blood pressure?

In some cases, excessive use of Glucolin DS IV Infusion 10%, especially when administered in large amounts intravenously, may lead to fluid retention and contribute to elevated blood pressure. It is important to monitor fluid balance during treatment.

21. Can Glucolin DS IV Infusion 10% be used for cancer patients?

Yes, Glucolin DS IV Infusion 10% can be used in cancer patients, particularly for those undergoing chemotherapy who may experience nausea, dehydration, or low blood sugar. It can help restore energy and maintain hydration levels.

22. Can Glucolin DS IV Infusion 10% be used for hypoglycemia in diabetic patients?

Yes, Glucolin DS IV Infusion 10% is commonly used for treating hypoglycemia (low blood sugar) in diabetic patients, particularly in emergency situations when a quick raise in blood glucose is necessary. It can be given orally or intravenously depending on the severity of the hypoglycemia.

23. How fast does Glucolin DS IV Infusion 10% work to raise blood sugar?

Glucolin DS IV Infusion 10% works quickly, typically raising blood sugar levels within 10-15 minutes of administration. It is absorbed rapidly into the bloodstream and provides immediate energy to the body.

24. Can Glucolin DS IV Infusion 10% cause allergic reactions?

Allergic reactions to Glucolin DS IV Infusion 10% are rare, but they can occur. Signs of an allergic reaction include rash, itching, difficulty breathing, and swelling. If any of these symptoms occur, seek medical attention immediately.

25. Can Glucolin DS IV Infusion 10% be used for dehydration in athletes?

Glucolin DS IV Infusion 10% can be used for hydration in athletes who experience dehydration after intense exercise, particularly when combined with electrolytes to restore balance. However, it should be used in moderation to prevent blood sugar imbalances.

26. How does Glucolin DS IV Infusion 10% help with brain function?

Since the brain primarily uses glucose for energy, Glucolin DS IV Infusion 10% helps provide a quick source of fuel for brain cells, especially during periods of low blood sugar. It is often used in emergency situations to treat hypoglycemia and prevent brain dysfunction.

27. Can Glucolin DS IV Infusion 10% be used for treating ketoacidosis?

Yes, Glucolin DS IV Infusion 10% is used in the treatment of diabetic ketoacidosis, but it is typically combined with insulin and fluids to help restore normal blood sugar levels and electrolyte balance.

28. How is Glucolin DS IV Infusion 10% different from sucrose?

Glucolin DS IV Infusion 10% is a simple sugar (monosaccharide) that is chemically identical to glucose. Sucrose, on the other hand, is a disaccharide made up of glucose and fructose. Glucolin DS IV Infusion 10% is absorbed more rapidly by the body and is a more direct source of energy.

29. Is Glucolin DS IV Infusion 10% safe for people with kidney disease?

Glucolin DS IV Infusion 10% should be used with caution in individuals with kidney disease, especially if they have fluid retention problems. It may require dose adjustments and careful monitoring of electrolytes and fluid balance.

30. Can Glucolin DS IV Infusion 10% help with nausea?

Glucolin DS IV Infusion 10% can help improve symptoms of nausea if it is caused by hypoglycemia or low blood sugar. Raising blood glucose levels can alleviate symptoms of nausea and dizziness associated with low sugar.

31. Can Glucolin DS IV Infusion 10% be used to treat hangovers?

Glucolin DS IV Infusion 10% can help alleviate some symptoms of a hangover, especially if low blood sugar is contributing to symptoms like dizziness and fatigue. However, it is not a cure for a hangover.

32. Can Glucolin DS IV Infusion 10% be used as a substitute for regular food?

Glucolin DS IV Infusion 10% is not a substitute for regular food because it does not provide all the essential nutrients the body needs. It is primarily used as a source of quick energy, especially in medical situations.

33. Can Glucolin DS IV Infusion 10% cause headaches?

In some cases, Glucolin DS IV Infusion 10% can cause headaches, particularly if blood sugar levels rise too quickly or if there is an electrolyte imbalance. Monitoring blood glucose levels can help minimize this risk.

34. Can Glucolin DS IV Infusion 10% be used for hypovolemic shock?

Glucolin DS IV Infusion 10% can be used as part of IV fluid therapy for hypovolemic shock, but it is usually combined with saline or other electrolytes. The goal is to restore fluid volume and stabilize blood sugar levels.

35. Is Glucolin DS IV Infusion 10% safe for infants?

Glucolin DS IV Infusion 10% is commonly used in infants, especially those with low blood sugar or dehydration. It is typically administered intravenously in carefully controlled doses.

36. What is the shelf life of Glucolin DS IV Infusion 10% solutions?

The shelf life of Glucolin DS IV Infusion 10% solutions typically ranges from 12 to 24 months, depending on the concentration and storage conditions. Always check the expiration date before use.

37. Can Glucolin DS IV Infusion 10% help with energy recovery after exercise?

Yes, Glucolin DS IV Infusion 10% is often used post-exercise to help replenish glycogen stores in muscles and improve energy recovery. It is particularly useful after intense physical activity that depletes the body’s glucose reserves.

38. Can Glucolin DS IV Infusion 10% be used in combination with other medications?

Glucolin DS IV Infusion 10% can be safely used with most medications, but it should be monitored in patients taking insulin or other glucose-lowering drugs. It may interact with these medications, requiring adjustments to dosages.

39. Can Glucolin DS IV Infusion 10% be used to treat seizures?

Glucolin DS IV Infusion 10% is often used in emergency settings to treat seizures caused by low blood sugar (hypoglycemia). It helps raise blood glucose levels, preventing further seizures caused by glucose depletion.

40. Can Glucolin DS IV Infusion 10% be taken orally in emergency situations?

Yes, Glucolin DS IV Infusion 10% can be taken orally in emergency situations, especially in the form of oral glucose gels or tablets. However, if the patient is unconscious or unable to swallow, intravenous administration is preferred.

41. Can Glucolin DS IV Infusion 10% help with fatigue?

Yes, Glucolin DS IV Infusion 10% can provide a quick energy boost, which may help alleviate fatigue caused by low blood sugar. It is especially useful in patients with hypoglycemia or those needing rapid energy recovery.

42. Can Glucolin DS IV Infusion 10% cause kidney damage?

There is no direct evidence that Glucolin DS IV Infusion 10% causes kidney damage. However, excessive use of Glucolin DS IV Infusion 10%, especially in patients with pre-existing kidney disease, may contribute to fluid retention and imbalances that could affect kidney function.

43. Can Glucolin DS IV Infusion 10% be used to treat alcohol poisoning?

Glucolin DS IV Infusion 10% is sometimes used in the treatment of alcohol poisoning, particularly if low blood sugar is contributing to the symptoms. It helps raise blood glucose levels and stabilize the patient.

44. How does Glucolin DS IV Infusion 10% compare to other glucose solutions?

Glucolin DS IV Infusion 10% is a simpler and more rapidly absorbed form of glucose than other types of glucose solutions. It provides a quick energy boost and is often used in emergencies for its fast action.

45. Can Glucolin DS IV Infusion 10% be used for people with heart disease?

While Glucolin DS IV Infusion 10% can be used in people with heart disease, it should be done with caution. It may contribute to fluid retention, which could exacerbate heart failure or other cardiac conditions. Monitoring is required during treatment.

46. Can Glucolin DS IV Infusion 10% cause a spike in insulin levels?

Yes, Glucolin DS IV Infusion 10% can cause a rapid spike in insulin levels because it raises blood sugar quickly. This may be problematic for individuals with insulin resistance or diabetes.

47. Can Glucolin DS IV Infusion 10% be used in surgery?

Glucolin DS IV Infusion 10% is sometimes used in surgical settings to provide energy and maintain blood sugar levels in patients undergoing surgery. It is often combined with other fluids, depending on the patient's needs.

48. Can Glucolin DS IV Infusion 10% help with hypothermia?

Glucolin DS IV Infusion 10% can help with hypothermia if the hypothermia is caused by low blood sugar. Raising blood glucose levels can improve energy and promote thermogenesis (heat production), aiding in recovery.

49. What happens if Glucolin DS IV Infusion 10% is accidentally given too quickly?

If Glucolin DS IV Infusion 10% is administered too quickly, it can cause a rapid spike in blood sugar, leading to hyperglycemia, fluid overload, and complications like vein irritation. It is important to administer it slowly and monitor the patient’s response.

50. Can Glucolin DS IV Infusion 10% cause an imbalance in electrolytes?

Yes, excessive use of Glucolin DS IV Infusion 10%, especially when administered rapidly, can contribute to imbalances in electrolytes like sodium, potassium, and calcium. Close monitoring of electrolyte levels is necessary during treatment.

Medical review

Last reviewed: 24 Jul 2026

Medically reviewed by:

This is general information, not personal medical advice. Consult a doctor before taking any medicine.

Glucolin DS IV Infusion