G-B-Benzoate Lotion

Introduction

Benzyl benzoate is a chemical compound used primarily as a topical treatment for scabies and lice infestations. It has also been used in some formulations as a solvent and a fragrance in various products. Its effectiveness as a pediculicide and acaricide makes it a valuable tool in treating parasitic infections.

Uses

Benzyl benzoate is used for:

Treating scabies, an infestation caused by the mite Sarcoptes scabiei.
Treating lice infestations, including head lice and pubic lice.
In some cases, it is used in combination with other agents in the treatment of other parasitic infections.

Brand Name	G-B-Benzoate
Type	Lotion
Weight	1.25 gm/5 ml
Generic	Benzyl Benzoate
Manufacturer	Gonoshasthaya Pharma Ltd.
Available in	English বাংলা

Mechanism of Action

Benzyl benzoate works by acting as an acaricide and pediculicide. It exerts its effects by disrupting the nervous system of mites and lice, leading to their paralysis and death. It also has some insect repellent properties that aid in the treatment and prevention of infestations.

How Long Does It Take to Work?

The effects of benzyl benzoate are usually observed within 24-48 hours of application. For complete eradication of scabies or lice, multiple applications may be required, and it is essential to follow the treatment regimen as directed by a healthcare provider.

Absorption

When applied topically, benzyl benzoate is minimally absorbed through the skin. The primary action occurs locally at the site of application, with systemic absorption being negligible in therapeutic doses.

Route of Elimination

Benzyl benzoate is metabolized in the liver and excreted primarily through the urine. Due to its low systemic absorption, significant elimination concerns are rare with topical use.

Dosage

Scabies: After a hot bath and drying, it is applied to the whole body except the head and face. If the application is thorough, one treatment should suffice, but the possibility of failure is lessened if a second application is made within 5 days of the first. Alternatively, Scabisol can be applied to the whole body, except the head and face, on three occasions at 12 hourly intervals. The patient has a hot both 12 hours after the last application and changes to clean clothes and sheets.

Pediculosis: The affected region is coated with Scabisol followed by a wash 24 hours later with soap and water. In severe cases this procedure may need to be repeated two or three times. An examination should always be made a week after the last treatment to confirm disinfestation.

USE IN CHILDREN: It can be diluted with an equal quantity of water for older children and with three parts of water for babies.

The dosage and application frequency of benzyl benzoate can vary based on the specific condition being treated and the formulation used. Typical guidelines include:

For scabies: Apply to the entire body from the neck down, leave on for 24 hours, and then wash off. Repeat if necessary, usually after one week.
For lice: Apply to the affected areas, leave on for 10-20 minutes, and then wash off. Repeat application as needed based on the severity of the infestation.

Administration

Benzyl benzoate is administered topically. It is usually applied directly to the affected areas of the skin, including the entire body for scabies. Proper application techniques and hygiene measures should be followed to ensure effective treatment and prevent re-infestation.

Side Effects

Common side effects include:

Skin irritation or rash at the site of application.
Dryness or peeling of the skin.

Less common but serious side effects may include:

Severe allergic reactions, such as hives or difficulty breathing.
Intense itching or burning sensation.

Toxicity

Toxicity is rare with topical use, but excessive or improper application can lead to systemic absorption and toxicity. Symptoms of toxicity may include nausea, headache, and dizziness. Seek medical attention if unusual symptoms occur.

Precautions

Precautions include:

Avoid application to broken or inflamed skin to reduce the risk of irritation.
Ensure the product does not come into contact with the eyes or mucous membranes.
Use with caution in patients with a history of hypersensitivity to benzyl benzoate or similar compounds.

Interaction

Benzyl benzoate has minimal drug interactions due to its topical application and low systemic absorption. However, combining it with other topical medications should be done cautiously to avoid potential interactions or increased irritation.

Disease Interaction

Use benzyl benzoate cautiously in patients with:

Severe eczema or psoriasis, as it may exacerbate skin irritation.
Impaired liver function, although systemic effects are minimal with topical use.

Drug Interaction

There are no significant drug interactions reported with benzyl benzoate when used topically. However, avoid simultaneous use with other topical agents that may cause skin irritation.

Food Interactions

There are no known food interactions with benzyl benzoate as it is applied topically and does not enter the gastrointestinal system.

Pregnancy Use

Benzyl benzoate should be used during pregnancy only if the potential benefits outweigh the risks. It is classified as a Category C drug, meaning that there is limited data on its safety during pregnancy. Consult a healthcare provider before use.

Lactation Use

The safety of benzyl benzoate during lactation is not well established. It is recommended to avoid application on the breast area to prevent potential ingestion by the infant. Consult a healthcare provider for advice on safe use while breastfeeding.

Acute Overdose

In the case of acute overdose, symptoms may include severe skin irritation or systemic effects if large amounts are ingested or absorbed. Seek immediate medical attention if overdose is suspected.

Contraindication

Benzyl benzoate is contraindicated in:

Patients with known hypersensitivity to benzyl benzoate or similar compounds.
Areas of broken or inflamed skin, where it may cause increased irritation.

Use Direction

Apply benzyl benzoate to clean, dry skin as directed by a healthcare provider. Ensure even coverage of affected areas, and follow the recommended duration of application to achieve optimal results.

Storage Conditions

Store benzyl benzoate at room temperature, away from direct light and moisture. Keep the container tightly closed and out of reach of children.

Volume of Distribution

The volume of distribution for benzyl benzoate is not well defined due to its topical application and minimal systemic absorption. Its effects are primarily localized to the application site.

Half Life

The half-life of benzyl benzoate is not well-documented due to its limited systemic absorption. Its action is primarily localized to the skin and has a short duration of activity based on application frequency.

Clearance

Benzyl benzoate is primarily cleared from the body through hepatic metabolism and renal excretion. Due to its low systemic absorption, clearance is primarily relevant for its metabolites and any unabsorbed drug.

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