Febuxit Tablet

Introduction

Febuxit Tablet 40 mg is used to reduce uric acid levels in adult patients with chronic gout. It is available in both tablet and capsule form. It is manufactured in the United States by Zydus Cadila.

Uses for

Febuxit Tablet 40 mg is used to reduce the uric acid levels in adult patients with chronic gout, and help reduce flares of gout pain and reduce the need for gout medication.

Brand Name	Febuxit
Type	Tablet
Weight	40 mg
Generic	Febuxostat
Manufacturer	Opsonin Pharma Ltd.
Available in	English বাংলা

Mechanism of Action

Febuxit Tablet 40 mg works by inhibiting xanthine oxidase, an enzyme involved in the production of uric acid. By inhibiting this enzyme, it helps to reduce the levels of uric acid in the blood.

How Long Does it Take to Work?

It usually takes 1-2 weeks for Febuxit Tablet 40 mg to reduce levels of uric acid. It may take longer for some patients to experience a reduction in gout pain.

Absorption

Febuxit Tablet 40 mg is well absorbed after oral administration, with the maximum levels reached in the blood in 3-5 hours.

Route of Elimination

Febuxit Tablet 40 mg is eliminated primarily through the kidneys, with over 80% of the administered dose excreted in urine.

Dosage

The recommended starting dose: Febuxostat 40 mg tablet once daily. For patients who do not achieve a serum uric acid less than 6 mg per dL after 2 weeks with Febuxostat 40 mg tablet, One Febuxostat 80 mg tablet once daily is recommended. If serum uric acid less than 6 mg per dL after 2-4 weeks with Xanuric 80 (Febuxostat 80mg) tablet, then one Febuxostat 120 mg tablet once daily is recommended.

Tumor Lysis Syndrome: The recommended dose is one Febuxostat 120 mg tablet once daily. Febuxostat 120 mg tablet should be started two days before the beginning of cytotoxic therapy and continued for a minimum of 7 days. However treatment may be prolonged up to 9 days according to chemotherapy duration as per clinical judgment.

Gout Flares: Gout flares may occur after initiation of Feboxostat tablets due to changing serum uric acid levels resulting in mobilization of urate from tissue deposits. Flare prophylaxis with a non-steroidal anti-inflammatory drug (NSAID) or colchicine is recommended upon initiation of Febuxostat tablets. If a gout flare occurs during treatment, Feboxostat tablets need not be discontinued. The gout flare should be managed concurrently, as appropriate for the individual patient.

Renal impairment: No dose adjustment is necessary when administering Febuxostat in patients with mild to moderate renal impairment.

Hepatic impairment: No dose adjustment is necessary in patients with mild to moderate hepatic impairment.

Pediatric Use: Safety and effectiveness in pediatric patients under 18 years of age have not been established The usual dose for adults is 40-80 mg once daily or 40 mg twice a day. The selected dosage should be individualized. The dose may be increased or decreased based on response to therapy. For patients with mild hepatic impairment, a maximum daily dose of 40 mg should not be exceeded. For patients with moderate or severe hepatic impairment, a maximum daily dose of 20 mg should not be exceeded.

Administration

Febuxit Tablet 40 mg should be taken by mouth as a whole capsule or tablet, with or without food.

Side Effect

The most common side effects of Febuxit Tablet 40 mg include headache, diarrhea, nausea, vomiting, stomach pain, and rash. In rare cases, serious liver injury, heart attack, and allergic reactions have been reported.

Toxicity

Febuxit Tablet 40 mg is generally well tolerated when used as prescribed. In rare cases, serious liver injury, heart attack, and allergic reactions have been reported.

Precaution

Patients should be monitored for elevated liver enzymes, and stopped if an increase is detected. Febuxit Tablet 40 mg should not be used in patients with severe liver or kidney diseases.

Interaction

Febuxit Tablet 40 mg may interact with other medications, including diuretics, nonsteroidal anti-inflammatory drugs (NSAIDS), and aspirin. Patients should inform their healthcare provider of any other medications they are taking.

Disease Interaction

Febuxit Tablet 40 mg should not be used in patients with a known hypersensitivity to the drug, severe liver or kidney impairment, or moderate to severe heart failure.

Drug Interaction

Febuxit Tablet 40 mg may interact with other medications, including diuretics, NSAIDS, warfarin, and aspirin. Patients should inform their healthcare provider of any other medications they are taking.

Food Interaction

Febuxit Tablet 40 mg should be taken with food or on an empty stomach.

Pregnancy Use

Febuxit Tablet 40 mg should not be used during pregnancy unless specifically indicated.

Lactation Use

It is not known whether Febuxit Tablet 40 mg is excreted in human milk. So, Febuxit Tablet 40 mg should not be used in the lactating women unless specifically indicated.

Acute Overdose

Symptoms of an acute overdose include confusion, dizziness, nausea, vomiting, and abdominal pain. Seek medical attention immediately if an overdose is suspected.

Contraindication

Febuxit Tablet 40 mg is contraindicated in patients with a known hypersensitivity to the drug, severe liver or kidney impairment, or moderate to severe heart failure.

Use Direction

Follow the directions on the prescription label carefully and take Febuxit Tablet 40 mg exactly as prescribed. The usual dose for adults is 40-80 mg once daily or 40 mg twice a day.