Brand Name Emezin
Type Tablet
Weight 50 mg
Generic Meclizine Hydrochloride
Manufacturer Eskayef Pharmaceuticals Ltd.
Price Unit: ৳ 2.50 (5 x 10: ৳ 125.00) Strip: ৳ 25.00

About Emezin

Emezin Tablet (Eskayef Pharmaceuticals Ltd.) is a brand medicine containing the generic Meclizine Hydrochloride . Current listed price in Bangladesh: Unit: ৳ 2.50 (5 x 10: ৳ 125.00) Strip: ৳ 25.00.

Medical information for Emezin Tablet 50 mg

Uses, dosage, side effects, and safety details below apply to Emezin Tablet 50 mg (generic: Meclizine Hydrochloride). This is general information — consult a doctor before use.

Introduction

Meclizine is a histamine H1 antagonist with antiemetic and antivertigo properties. It is used in the symptomatic treatment of motion sickness and control of vertigo associated with vestibular system diseases. It also exhibits anticholinergic, central nervous system depressant, and local anesthetic effects.

Uses

Meclizine is a histamine H1 antagonist used to treat nausea, vomiting, and dizziness associated with motion sickness.

Indicated for the symptomatic treatment of nausea, vomiting, and dizziness associated with motion sickness, and management of vertigo due to various causes, including radiation sickness, Meniere’s syndrome, labyrinthitis and other vestibular disturbances.

Associated Conditions

  • Dizziness
  • Motion Sickness

Pharmacodynamics

Meclizine works on the higher centres of the brain to reduce nausea, vomiting, or vertigo. It is effective against nausea and vomiting arising from many causes, including motion sickness and disorders affecting the vestibular system. The onset of action of meclizine is about 1 hour, with effects lasting between 8 to 24 hours. Meclizine is reported to cause drowsiness due to its anticholinergic actions.

Mechanism of Action

Vomiting is a centrally regulated reflex mechanism that initiates from the vomiting center and the chemoreceptor trigger zone (CTZ) located in the medulla. Motion sickness is also regulated by CTZ. The blood-brain barrier near the CTZ is relatively permeable to circulating mediators and CTZ can transmit impulses to vomiting center located in the brainstem. Different receptors responding to different factors, including histamine, 5-HT, enkephalins, substance P, and dopamine, are expressed along the brainstem to activate respective pathways and contribute to the control of vomiting. Histamine H1 receptors are expressed on the vestibular nuclei and nucleus of the solitary tract (NTS) that are activated by motion sickness and stimuli from the pharynx and stomach. When activated, H1 receptor signaling from these nuclei is transmitted to the CTZ and vomiting centre.

Through its antagonistic action on the H1 receptors, meclizine primarily works by inhibiting signaling pathway transduction through histaminergic neurotransmission from the vestibular nuclei and NTS to the CTZ and medullary vomiting center. Meclizine may also decrease the labyrinth excitability and vestibular stimulation.

Absorption

Most histamine H1 antagonists are reported to be readily absorbed following oral administration. Upon oral administration, the time to reach peak plasma concentrations (Cmax) of meclizine is about 3 hours post-dose, with the value ranging from 1.5 to 6 hours.

Volume of Distribution

The volume of distribution of meclizine in humans has not been fully studied. It is proposed that meclizine may be excreted into breast milk.

Protein Binding

There is limited data on the protein binding profile of meclizine.

Route of Elimination

Meclizine is excreted in the urine as metabolites and in the feces as unchanged drug.

Half Life

Meclizine has a plasma elimination half-life of about 5-6 hours in humans.

Clearance

There is limited data on the clearance of meclizine.

Toxicity

The oral and intraperitoneal LD50 in mouse are 1600 mg/kg and 625 mg/kg, respectively. The lowest published toxic dose (TDLo) in rats via the oral route is 800 mg/kg.

Symptoms of overdose mainly involve CNS depression with drowsiness, coma, and convulsions. Hypotension may also occur, particularly in the elderly. In children, anticholinergic effects and CNS stimulation, characterized by hallucinations, seizures, trouble sleeping, are more likely to occur. In case of overdose, symptomatic and supportive treatment is recommended. In case of recent ingestion, induction of emesis or gastric lavage should be initiated to limit further drug absorption. Although there is no known antidote to meclizine, physostigmine may be useful to counteract the CNS anticholinergic effects of meclizine.

Food Interactions

  • Avoid alcohol. Alcohol may cause additive CNS depressant effects.

Dosage

Adult & children over 12 years of age:
  • Nausea and vomiting: 25-50 mg once daily.
  • Motion sickness: Take an initial dose of 25 to 50 mg, 1 hour prior to travel. May repeat dose every 24 hours for the duration of the journey. Children: Age 6-12 years, 12.5 mg once daily. Age 2-6 years, 6.25 mg once daily.
  • Vertigo: 25 to 100 mg daily in divided doses.
  • Radiotherapy induced nausea and vomiting: 50 mg two to twelve hours prior to radiotherapy.
  • Emergency contraception: 25-50 mg, 1 hour before first ECP dose; repeat if needed in 24 hours.
Use in children: Clinical studies establishing safety and efficacy in children have not been done; therefore, its use should be determined by physician.

Use in elderly: There is no specific information available. However older people may be especially sensitive to the anticholinergic effects of medicine.

Frequently Asked Questions About Emezin Tablet 50 mg

1. What is Emezin Tablet 50 mg?

Emezin Tablet 50 mg is an antihistamine used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness and vertigo. It is also used for treating allergic reactions such as hay fever and sneezing.

2. How does Emezin Tablet 50 mg work?

Emezin Tablet 50 mg works by blocking histamine receptors in the brain, reducing the effects of histamine that contribute to symptoms of motion sickness and vertigo. It also acts on the vestibular system to reduce dizziness and nausea.

3. What is Emezin Tablet 50 mg used for?

Emezin Tablet 50 mg is primarily used for:

  • Preventing and treating motion sickness
  • Managing dizziness and vertigo caused by inner ear problems such as benign paroxysmal positional vertigo (BPPV)
  • Treating allergic conditions such as rhinitis and hay fever

4. How should I take Emezin Tablet 50 mg?

Emezin Tablet 50 mg is typically taken orally, with or without food. The recommended dosage is usually 25 to 50 mg taken once a day, but it can vary depending on the condition being treated. Always follow your doctor’s instructions for the correct dosage.

5. Can I take Emezin Tablet 50 mg with other medications?

Emezin Tablet 50 mg can interact with other medications, particularly those that cause drowsiness or have central nervous system (CNS) depressant effects, such as alcohol, benzodiazepines, and sedatives. Always inform your healthcare provider of all medications you're taking.

6. What are the common side effects of Emezin Tablet 50 mg?

Common side effects include:

  • Drowsiness or sleepiness
  • Dry mouth
  • Headache
  • Blurred vision
  • Constipation

If you experience any severe side effects such as difficulty breathing or swelling, seek medical attention immediately.

7. Can I drive after taking Emezin Tablet 50 mg?

Emezin Tablet 50 mg can cause drowsiness, so it is recommended to avoid driving or operating heavy machinery until you know how the medication affects you. Always assess your level of alertness before engaging in activities that require full concentration.

8. Can Emezin Tablet 50 mg cause an allergic reaction?

While rare, an allergic reaction to Emezin Tablet 50 mg is possible. Symptoms of an allergic reaction may include hives, swelling of the face or throat, difficulty breathing, and a rash. Seek emergency medical help if you experience any of these symptoms.

9. Can I take Emezin Tablet 50 mg if I am pregnant?

Emezin Tablet 50 mg is categorized as a pregnancy category B medication, which means it is generally considered safe during pregnancy. However, it is always best to consult with your healthcare provider before taking any medication during pregnancy.

10. Can I take Emezin Tablet 50 mg while breastfeeding?

Emezin Tablet 50 mg passes into breast milk in small amounts. While it is generally considered safe for breastfeeding, you should consult your doctor before taking this medication while nursing to ensure it is appropriate for you and your baby.

11. How should Emezin Tablet 50 mg be stored?

Store Emezin Tablet 50 mg at room temperature, away from moisture and heat. Keep it in its original packaging and out of reach of children.

12. What should I do if I miss a dose of Emezin Tablet 50 mg?

If you miss a dose, take it as soon as you remember, unless it’s almost time for your next dose. In that case, skip the missed dose and take your next dose at the regular time. Do not take extra medication to make up for a missed dose.

13. Can Emezin Tablet 50 mg be taken for long periods?

Emezin Tablet 50 mg is generally intended for short-term use, especially for conditions like motion sickness and vertigo. Long-term use should be done under the guidance of a healthcare provider to assess any potential side effects or risks.

14. Can Emezin Tablet 50 mg cause drowsiness?

Yes, drowsiness is a common side effect of Emezin Tablet 50 mg. If you experience drowsiness, it is advised to avoid activities that require full concentration, such as driving or operating machinery.

15. Is Emezin Tablet 50 mg safe for children?

Emezin Tablet 50 mg is generally not recommended for children under the age of 12, as the safety and effectiveness have not been established for younger populations. Consult your healthcare provider for the appropriate treatment for children.

16. Can Emezin Tablet 50 mg be used for nausea and vomiting caused by chemotherapy?

Emezin Tablet 50 mg may help reduce nausea and vomiting in some patients, but it is not typically used for nausea caused by chemotherapy. Other antiemetic medications are often prescribed for this purpose.

17. Can Emezin Tablet 50 mg be used to treat motion sickness in pets?

Emezin Tablet 50 mg is sometimes prescribed by veterinarians for dogs with motion sickness. However, you should not give this medication to your pet without consulting a veterinarian first.

18. What is the difference between Emezin Tablet 50 mg and Dramamine?

Emezin Tablet 50 mg is the active ingredient in Dramamine, which is an over-the-counter medication used to treat motion sickness and nausea. Emezin Tablet 50 mg is the generic form, while Dramamine is the branded version.

19. What should I do if I accidentally overdose on Emezin Tablet 50 mg?

If you believe you have overdosed on Emezin Tablet 50 mg, contact a healthcare professional or poison control center immediately. Symptoms of an overdose may include severe drowsiness, dry mouth, blurry vision, and difficulty urinating.

20. Does Emezin Tablet 50 mg interact with alcohol?

Alcohol can increase the sedative effects of Emezin Tablet 50 mg, leading to increased drowsiness and other side effects. It is recommended to avoid drinking alcohol while taking this medication.

21. How does Emezin Tablet 50 mg help with vertigo?

Emezin Tablet 50 mg works by blocking histamine receptors in the brain, which helps reduce the symptoms of dizziness and vertigo caused by inner ear problems. It can also help prevent nausea associated with these conditions.

22. Can Emezin Tablet 50 mg be taken before flying to prevent motion sickness?

Yes, Emezin Tablet 50 mg can be taken before travel to prevent motion sickness. It’s recommended to take the medication about an hour before travel to allow it to take effect.

23. Is there a non-prescription version of Emezin Tablet 50 mg?

Yes, Emezin Tablet 50 mg is available over-the-counter in some countries, especially in motion sickness products like Dramamine. However, higher doses may require a prescription.

24. Can Emezin Tablet 50 mg be used for inner ear infections?

Emezin Tablet 50 mg is not specifically used to treat inner ear infections, but it can help manage dizziness and nausea that may occur due to the infection. You should consult your doctor for appropriate treatment of ear infections.

25. Can I use Emezin Tablet 50 mg for dizziness caused by low blood pressure?

Emezin Tablet 50 mg is not recommended for dizziness caused by low blood pressure. It’s important to address the underlying cause of the dizziness. Consult your doctor for advice on treatment options for low blood pressure-related dizziness.

26. Can Emezin Tablet 50 mg be used for nausea during pregnancy?

Emezin Tablet 50 mg is considered safe during pregnancy for short-term use, especially for nausea related to motion sickness. However, it’s best to consult your healthcare provider before using any medication during pregnancy.

27. How does Emezin Tablet 50 mg compare to other antihistamines for dizziness?

Emezin Tablet 50 mg is a first-generation antihistamine that has a sedative effect, which makes it effective for treating dizziness associated with vertigo and motion sickness. However, other antihistamines may be less sedating but may not be as effective for treating motion sickness.

28. Does Emezin Tablet 50 mg help with nausea caused by anxiety?

Emezin Tablet 50 mg is not typically used for nausea related to anxiety. While it can help with nausea from motion sickness or vertigo, medications specifically targeting anxiety may be more appropriate for anxiety-related symptoms.

29. What should I do if I have difficulty swallowing Emezin Tablet 50 mg tablets?

If you have trouble swallowing tablets, you can ask your doctor or pharmacist if the medication is available in a liquid form or if crushing the tablets is an option. Never crush medication without consulting a healthcare professional first.

30. Can Emezin Tablet 50 mg be used to treat nausea caused by migraines?

Emezin Tablet 50 mg may help manage the nausea associated with migraines, but it is not a first-line treatment. Other medications specifically designed for migraine relief, such as triptans, are often used.

31. Does Emezin Tablet 50 mg help with nausea from chemotherapy?

Emezin Tablet 50 mg may be used for nausea related to chemotherapy, but other medications such as ondansetron or metoclopramide are more commonly prescribed for this purpose.

32. Can I stop taking Emezin Tablet 50 mg if I no longer feel dizzy?

It’s important to follow your doctor’s guidance on how to discontinue Emezin Tablet 50 mg. Even if symptoms improve, your doctor may recommend tapering the dosage to avoid a recurrence of dizziness or vertigo.

33. Is Emezin Tablet 50 mg effective for nausea during pregnancy?

Emezin Tablet 50 mg may be prescribed to manage nausea and vomiting during pregnancy, especially for morning sickness. However, always consult with your healthcare provider before using any medication during pregnancy.

34. Can Emezin Tablet 50 mg be taken if I have a history of seizures?

If you have a history of seizures, consult your doctor before taking Emezin Tablet 50 mg. While it’s not known to directly cause seizures, it may have interactions with other medications or conditions.

35. Can I use Emezin Tablet 50 mg for motion sickness if I have asthma?

Emezin Tablet 50 mg is generally safe for individuals with asthma, but you should consult your doctor to ensure it doesn’t interact with your asthma medications or trigger symptoms.

36. Does Emezin Tablet 50 mg cause weight gain?

Weight gain is not a common side effect of Emezin Tablet 50 mg. However, if you notice unexplained weight changes, consult your healthcare provider.

37. How long does it take for Emezin Tablet 50 mg to work?

Emezin Tablet 50 mg typically starts working within one hour of ingestion, with effects lasting up to 24 hours. The exact timing may vary depending on individual response.

38. Can I take Emezin Tablet 50 mg for morning sickness?

Emezin Tablet 50 mg can be used to treat morning sickness, but you should only take it under the guidance of your healthcare provider, as other treatments may be more effective or safer during pregnancy.

39. Can Emezin Tablet 50 mg be used for anxiety-induced dizziness?

Emezin Tablet 50 mg is not typically used for dizziness caused by anxiety. It’s designed to treat dizziness from conditions like vertigo or motion sickness. Consult your doctor for appropriate treatment of anxiety-related symptoms.

40. Can Emezin Tablet 50 mg be used in elderly patients?

Emezin Tablet 50 mg is generally safe for elderly patients, but they may be more sensitive to the medication’s sedative effects. Dose adjustments may be necessary, so always consult with your doctor.

41. Can Emezin Tablet 50 mg cause dry mouth?

Dry mouth is a common side effect of Emezin Tablet 50 mg. To help alleviate dry mouth, drink plenty of water, suck on sugar-free lozenges, or chew sugar-free gum.

42. Is Emezin Tablet 50 mg addictive?

Emezin Tablet 50 mg is not addictive. However, it should be taken only as prescribed to avoid potential misuse or side effects.

43. Can Emezin Tablet 50 mg interact with antidepressants?

Emezin Tablet 50 mg may interact with certain antidepressants, particularly those that have sedative effects. Always inform your healthcare provider of all medications you are taking.

44. Can I use Emezin Tablet 50 mg to treat seasickness?

Yes, Emezin Tablet 50 mg is effective in preventing and treating seasickness, as it helps control dizziness and nausea caused by motion.

45. What should I do if I experience side effects while taking Emezin Tablet 50 mg?

If you experience severe side effects, such as difficulty breathing, swelling, or irregular heartbeat, seek emergency medical help. For milder side effects like drowsiness or dry mouth, consult your doctor for advice.

46. Can Emezin Tablet 50 mg cause blurry vision?

Blurry vision is a potential side effect of Emezin Tablet 50 mg due to its anticholinergic properties. If you experience blurry vision, contact your healthcare provider.

47. How long can I safely take Emezin Tablet 50 mg for motion sickness?

Emezin Tablet 50 mg can be taken for short-term relief of motion sickness. If you need to use it frequently, consult your doctor to determine if there are underlying issues or if an alternative treatment is needed.

48. Does Emezin Tablet 50 mg cause constipation?

Constipation is a possible side effect of Emezin Tablet 50 mg. If you experience constipation, increase your fiber intake, drink plenty of water, and consult your doctor for additional guidance.

49. Can Emezin Tablet 50 mg be used for nausea caused by migraines?

Emezin Tablet 50 mg may help alleviate nausea associated with migraines, but it is not typically used as a primary treatment for migraines. Other medications are more effective in managing migraines.

50. Can Emezin Tablet 50 mg be used for anxiety-induced dizziness?

Emezin Tablet 50 mg is not used to treat dizziness caused by anxiety. It is specifically designed for vertigo and motion sickness. Consult a healthcare provider for treatment options for anxiety-induced dizziness.

Medical review

Last reviewed: 24 Jul 2026

Medically reviewed by:

This is general information, not personal medical advice. Consult a doctor before taking any medicine.

Taking medicines without doctor's advice can cause long-term problems.
Dr. Maruf Bin Habib

Dr. Maruf Bin Habib

Medicine, Diabetes & Rheumatology Specialist

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Dr. Tasneem Ara

Dr. Tasneem Ara

Blood Diseases, Blood Cancer & Bone Marrow Transplant Specialist

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