Distamin Tablet

Introduction

Distamin Tablet 4 mg is a first-generation antihistamine that has been used for the treatment of allergic rhinitis and urticaria. It is also an anti-inflammatory agent, used to help reduce congestion, sneezing, headaches, and other allergies caused by exposure to pollen and other allergens. It is a racemic mixture, containing equal amounts of both the (+) and (–) enantiomers.

Uses

Distamin Tablet 4 mg is used to provide relief from seasonal allergies such as hay fever, allergic conjunctivitis, and upper respiratory allergies. It is also used to relieve the itching and swelling of hives and other skin allergies. It may also be used to treat the symptoms of allergic rhinitis, such as sneezing, runny nose, and itchy eyes.

Brand Name	Distamin
Type	Tablet
Weight	4 mg
Generic	Chlorpheniramine Maleate
Manufacturer	Doctor’s Chemical Works Ltd.
Available in	English বাংলা

Mechanism of Action

Distamin Tablet 4 mg works by blocking the action of histamines, which are chemical messengers released during an allergic reaction. Histamines are responsible for the symptoms of allergic reactions, such as itching, sneezing, and swelling. By blocking their action, Distamin Tablet 4 mg helps to reduce these symptoms.

How Long Does it Take to Work?

Distamin Tablet 4 mg usually begins to work within 30 minutes of taking it. Maximum relief may not be experienced for up to 4 hours after taking the medication.

Absorption

Distamin Tablet 4 mg is rapidly and completely absorbed from the gastrointestinal (GI) tract after oral administration.

Route of Elimination

Distamin Tablet 4 mg is eliminated primarily in the urine, with a small amount excreted in the feces.

Dosage

Adult- Usual adult dose is 4 mg every 4-6 hours, maximum 24 mg daily.

Child-

6-12 years: 2 mg every 4-6 hours, maximum 12 mg daily.
2-5 years: 1 mg every 4-6 hours, maximum 6 mg daily.
1-2 years: 1 mg twice daily.

Below 1 year the use of Chlorpheniramine Maleate is not recommended. The adult dose of Distamin Tablet 4 mg for allergies is 4 mg taken twice daily. For hives, the adult dose is 4 mg taken 3 times daily. For children between 6-12 years old, the dose is 2 mg taken twice daily. For children younger than 6 years old, the dose should be determined by the healthcare provider.

Administration

Distamin Tablet 4 mg should be taken orally with or without food. Do not exceed the recommended dosage and do not take this medication for longer than recommended by your healthcare provider.

Side Effects

Common side effects of Distamin Tablet 4 mg include dry mouth, dizziness, drowsiness, nausea, vomiting, and headaches. Serious side effects may include difficult urination, blurred vision, confusion, tremors, and seizures.

Toxicity

In studies, Distamin Tablet 4 mg was found to have relatively low acute toxicity and high chronic toxicity. Chronic toxicity can cause fatal respiratory failure.

Precaution

Patients should not drive or operate heavy machinery while taking Distamin Tablet 4 mg due to the risk of drowsiness or dizziness. Alcohol should be avoided while taking this medication as it may intensify side effects. This medication should be taken with caution by patients with glaucoma, prostate problems, liver or kidney disease, or any other medical condition.

Interaction

Distamin Tablet 4 mg may interact with other medications. Patients should tell their healthcare provider about all the medications they are taking, including prescription, non-prescription, and herbal medications.

Disease Interaction

Patients with certain diseases, such as glaucoma, liver or kidney disease, and prostate problems, may be at increased risk for certain side effects when taking Distamin Tablet 4 mg.

Drug Interaction

Distamin Tablet 4 mg may interact with other drugs including: narcotics, sedatives, other antihistamines, muscle relaxants, and antispasmodics.

Food Interactions

Distamin Tablet 4 mg may interact with certain foods such as citrus fruits.

Pregnancy Use

Distamin Tablet 4 mg should not be used during pregnancy, unless recommended by a healthcare provider.

Lactation Use

Distamin Tablet 4 mg should not be used while breastfeeding, unless recommended by a healthcare provider.

Acute Overdose

An acute overdose of Distamin Tablet 4 mg can cause symptoms such as shallow breathing, drowsiness, confusion, and coma. Patients with an overdose of this medication should seek medical help immediately.

Contraindication

Distamin Tablet 4 mg is contraindicated in patients with a known hypersensitivity to it or its components.

Use Direction

Distamin Tablet 4 mg should be taken exactly as directed by your healthcare provider. Do not exceed the recommended dosage or take this medication for longer than recommended by your healthcare provider.