Clobenate Ointment 0.05% 0.05% Uses, Dosage, Side Effects & Price - ক্লোবেনেট অয়েন্টমেন্ট

Brand Name	Clobenate
Type	Ointment
Weight	0.05%
Generic	Clobetasol Propionate
Manufacturer	Julphar Bangladesh Ltd.

Brand Name

Clobenate

Type

Ointment

Weight

0.05%

Generic

Clobetasol Propionate

Manufacturer

Julphar Bangladesh Ltd.

About Clobenate

Clobenate Ointment (Julphar Bangladesh Ltd.) is a brand medicine containing the generic Clobetasol Propionate .

Introduction

Clobetasol propionate is a prednisolone derivative with higher specificity for glucocorticoid receptors than mineralocorticoid receptors.

Uses

Clobetasol propionate is a corticosteroid used to treat corticosteroid-responsive dermatoses and plaque psoriasis.

Clobetasol propionate is indicated to treat moderate to severe plaque psoriasis as well as inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.

Associated Conditions

Alopecia
Severe Plaque psoriasis
Corticosteroid responsive
Inflammatory Dermatosis
Corticosteroid responsive
pruritic Dermatosis
Moderate Plaque psoriasis
Moderate Scalp Psoriasis
Severe Scalp Psoriasis

Pharmacodynamics

Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals. Clobetasol propionate is generally applied twice daily so the duration of action is long. Corticosteroids have a wide therapeutic window as patients may require doses that are multiples of what the body naturally produces. Patients taking corticosteroids should be counselled regarding the risk of hypothalamic-pituitary-adrenal axis suppression and increased susceptibility to infections.

Mechanism of Action

The short term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation. Corticosteroids binding to the glucocorticoid receptor mediates changes in gene expression that lead to multiple downstream effects over hours to days.

Glucocorticoids inhibit neutrophil apoptosis and demargination; they inhibit phospholipase A2, which decreases the formation of arachidonic acid derivatives; they inhibit NF-Kappa B and other inflammatory transcription factors; they promote anti-inflammatory genes like interleukin-10.

Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive. High doses of glucocorticoids for an extended period bind to the mineralocorticoid receptor, raising sodium levels and decreasing potassium levels.

Absorption

Twice daily application of clobetasol foam leads to a C_max of 59±36pg/mL with a T_max of 5 hours. Clobetasol cream showed an increase in clobetasol concentrations from 50.7±96.0pg/mL to 56.3±104.7pg/mL.

Volume of Distribution

Data regarding the volume of distribution of clobetasole propionate are not readily available.

Protein Binding

Data regarding the protein binding of clobetasol propionate are not readily available. Corticosteroids are generally bound to corticosteroid binding globulin and serum albumin in plasma.

Route of Elimination

Corticosteroids are eliminated predominantly in the urine.

Half Life

Data regarding the half life of clobetasol propionate are not readily available.

Clearance

Data regarding the clearance of clobetasol propionate are not readily available.

Toxicity

Data regarding acute overdoses of glucocorticoids are rare. Overdoses of clobetasol propionate can lead to reversible HPA axis suppression and glucocorticoid insufficiency. Chronic high doses of glucocorticoids can lead to the development of cataract, glaucoma, hypertension, water retention, hyperlipidemia, peptic ulcer, pancreatitis, myopathy, osteoporosis, mood changes, psychosis, dermal atrophy, allergy, acne, hypertrichosis, immune suppression, decreased resistance to infection, moon face, hyperglycemia, hypocalcemia, hypophosphatemia, metabolic acidosis, growth suppression, and secondary adrenal insufficiency.[A188405] Overdose may be treated by adjusting the dose or stopping the corticosteroid as well as initiating symptomatic and supportive treatment.[A188405]

Food Interactions

No interactions found.

Dosage

Cream, Ointment: Adults, elderly and children over 1 year: Apply a thin layer of Clobenate Ointment 0.05% Cream or Ointment to the affected skin areas twice daily and rub in gently and completely. Repeated short courses of Clobenate Ointment 0.05% may be used to control exacerbations. In more resistant lesions, especially where there is hyperkeratosis, the effect of Clobetasol can be enhanced, if necessary, by occluding the treatment area with polythene film. Overnight occlusion only is usually adequate to bring about a satisfactory response.

Clobenate Ointment 0.05% is super-high potency topical corticosteroids; therefore, treatment should be limited to 2 consecutive weeks. The maximum weekly dose should not be exceeded 50 gm/week. In case of children, courses should be limited if possible to five days and reviewed weekly.

Spray: Apply required quantity of spray of once or twice daily to the affected areas of the scalp and gently rub in. The total dose applied should not exceed 50 ml weekly. If necessary, Clobenate Ointment 0.05% scalp solution may be massaged into the scalp using the tips of the fingers. Therapy should be discontinued if no response is noted after one week or as soon as the lesion heals. It is advisable to use Clobenate Ointment 0.05% scalp solution for brief periods only.

Shampoo: It should be applied to the dry (not wet) scalp once a day to the affected areas only. It should be massaged gently into the lesions and left in place for 15 minutes before lathering and rinsing. Treatment should be limited to 4 consecutive weeks. Total dosage of shampoo should not exceed 50 g per week. Under 18 years this preparation is not recommended.

Scalp Solution: Apply required quantity of spray of Clobetasol Scalp Solution once or twice daily to the affected areas of the scalp and gently rub in. The total dose applied should not exceed 50 ml weekly. If necessary, Clobetasol Scalp Solution may be massaged into the scalp using the tips of the fingers. Therapy should be discontinued if no response is noted after one week or as soon as the lesion heals. It is advisable to use Clobetasol Scalp Solution for brief periods only.

Frequently Asked Questions About Clobenate Ointment 0.05%

1. What is Clobenate Ointment 0.05%?

Clobenate Ointment 0.05% is a potent topical corticosteroid used to treat various skin conditions, such as eczema, psoriasis, and dermatitis. It helps reduce inflammation, redness, and swelling by suppressing immune responses in the skin.

2. How does Clobenate Ointment 0.05% work?

Clobenate Ointment 0.05% works by reducing inflammation and immune responses in the skin. It does this by suppressing the activity of certain chemicals in the body that cause inflammation and swelling.

3. What is Clobenate Ointment 0.05% used for?

Clobenate Ointment 0.05% is primarily used to treat inflammatory skin conditions such as:

Psoriasis
Atopic dermatitis (eczema)
Contact dermatitis
Seborrheic dermatitis
Other inflammatory skin conditions

4. How should I apply Clobenate Ointment 0.05%?

Clobenate Ointment 0.05% should be applied to the affected area as a thin layer once or twice daily, as directed by your healthcare provider. Avoid applying it to the face, groin, or underarms unless specifically instructed to do so. Do not apply it to broken skin or open wounds.

5. What are the common side effects of Clobenate Ointment 0.05%?

Common side effects of Clobenate Ointment 0.05% include:

Burning or stinging at the application site
Itching or irritation
Skin thinning
Stretch marks
Acne or folliculitis

If any of these side effects are severe or persistent, contact your healthcare provider.

6. What should I do if I accidentally swallow Clobenate Ointment 0.05%?

If you accidentally swallow Clobenate Ointment 0.05%, contact your healthcare provider or poison control immediately. Swallowing large amounts of corticosteroids can lead to serious side effects, such as adrenal suppression or stomach issues.

7. Can Clobenate Ointment 0.05% be used on the face?

Clobenate Ointment 0.05% is a potent corticosteroid and should generally not be used on the face unless prescribed by a doctor. Prolonged use on the face can cause skin thinning, irritation, and other side effects.

8. Can Clobenate Ointment 0.05% be used during pregnancy?

Clobenate Ointment 0.05% should only be used during pregnancy if clearly needed and prescribed by your doctor. It is classified as a Category C drug, meaning it could harm the fetus, so its use during pregnancy should be carefully considered.

9. Can Clobenate Ointment 0.05% be used while breastfeeding?

Clobenate Ointment 0.05% can be passed into breast milk in small amounts. It should only be used while breastfeeding if the benefits outweigh the potential risks. Always consult your healthcare provider before using it during breastfeeding.

10. Can I use Clobenate Ointment 0.05% with other topical medications?

Clobenate Ointment 0.05% may interact with other topical medications. It is important to inform your healthcare provider of all the medications you are using, including other topical treatments, to avoid adverse interactions.

11. How long can I use Clobenate Ointment 0.05%?

Clobenate Ointment 0.05% should not be used for prolonged periods. Typically, it is recommended for short-term use (up to two weeks) due to the risk of skin thinning and other side effects. Long-term use should be monitored by a healthcare provider.

12. What should I do if I miss a dose of Clobenate Ointment 0.05%?

If you miss a dose of Clobenate Ointment 0.05%, apply it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra to make up for a missed dose.

13. Can Clobenate Ointment 0.05% cause skin thinning?

Yes, one of the known side effects of Clobenate Ointment 0.05% is skin thinning, especially with prolonged use. This can increase the risk of skin bruising and other skin issues. To minimize this risk, use the medication only as prescribed and for the shortest duration possible.

14. Can I use Clobenate Ointment 0.05% on my scalp?

Yes, Clobenate Ointment 0.05% can be used on the scalp for conditions like psoriasis or seborrheic dermatitis, but it should be applied carefully to avoid excessive use. It is important to follow your doctor's instructions regarding its application to your scalp.

15. Can Clobenate Ointment 0.05% cause stretch marks?

Yes, Clobenate Ointment 0.05% can cause stretch marks (striae), particularly with long-term use or use in areas of skin that are stretched, such as the abdomen or thighs. If you notice stretch marks, inform your healthcare provider.

16. What should I do if Clobenate Ointment 0.05% causes irritation or allergic reaction?

If Clobenate Ointment 0.05% causes irritation, redness, or signs of an allergic reaction (such as rash, swelling, or difficulty breathing), stop using the medication and seek medical attention immediately.

17. Can Clobenate Ointment 0.05% be used on children?

Clobenate Ointment 0.05% should be used cautiously in children, as they may be more susceptible to side effects, such as skin thinning or growth suppression. It should only be used under the supervision of a healthcare provider.

18. What are the potential long-term effects of using Clobenate Ointment 0.05%?

Long-term use of Clobenate Ointment 0.05% can lead to several side effects, including skin thinning, stretch marks, delayed wound healing, and increased risk of infections. Prolonged use may also affect the body's production of natural steroids.

19. Can I use Clobenate Ointment 0.05% if I have diabetes?

Clobenate Ointment 0.05% may raise blood sugar levels, which can be problematic for people with diabetes. If you have diabetes, consult your healthcare provider before using this medication.

20. Can Clobenate Ointment 0.05% interact with oral steroids?

Clobenate Ointment 0.05%, when used with oral steroids, may increase the risk of systemic corticosteroid side effects, such as adrenal suppression. Your doctor should monitor your use of both medications.

21. How can I reduce the risk of side effects from Clobenate Ointment 0.05%?

To minimize side effects, use Clobenate Ointment 0.05% only as prescribed, apply it to a small area of skin, and avoid prolonged use. Consult your healthcare provider if you experience any side effects or if you need to use the medication for an extended period.

22. Can I use Clobenate Ointment 0.05% after a sunburn?

It is not recommended to use Clobenate Ointment 0.05% on sunburned or damaged skin, as it may worsen irritation or sensitivity. Wait until your skin has healed before applying the medication.

23. How does Clobenate Ointment 0.05% compare to other corticosteroids?

Clobenate Ointment 0.05% is one of the most potent topical corticosteroids available. It is typically used for severe inflammatory skin conditions when milder corticosteroids have not been effective. Other corticosteroids vary in strength, with Clobetasol being among the strongest.

24. Can I use Clobenate Ointment 0.05% for acne?

Clobenate Ointment 0.05% is not recommended for acne treatment. In fact, topical corticosteroids can sometimes worsen acne by promoting the growth of pimples and pustules.

25. Can Clobenate Ointment 0.05% be used for allergic reactions?

Clobenate Ointment 0.05% can help treat the inflammation associated with allergic skin reactions, but it is not a first-line treatment for allergies. Antihistamines or other medications may be preferred for allergic reactions.

26. What should I do if Clobenate Ointment 0.05% makes my skin worse?

If Clobenate Ointment 0.05% worsens your skin condition, stop using it and contact your healthcare provider. You may require a different treatment or additional instructions for proper use.

27. Can Clobenate Ointment 0.05% help with sunburns?

Clobenate Ointment 0.05% is not recommended for sunburn treatment. For sunburns, soothing agents like aloe vera or hydrocortisone may be more appropriate.

28. How soon will I see results from Clobenate Ointment 0.05%?

Many people begin to see improvements in their skin condition within a few days to a week of using Clobenate Ointment 0.05%. However, the exact time will depend on the severity of the condition and how your skin responds to the treatment.

29. Can Clobenate Ointment 0.05% be used on the genitals?

Clobenate Ointment 0.05% should be used with caution on the genital area, as this area is more sensitive. It may be prescribed in certain cases, but it should be used under strict medical supervision.

30. Can I use Clobenate Ointment 0.05% for rashes caused by insect bites?

Clobenate Ointment 0.05% may help reduce the inflammation caused by insect bites, but it is not typically the first choice for treating bug bites. Over-the-counter antihistamines or hydrocortisone creams are often recommended.

31. How should I store Clobenate Ointment 0.05%?

Store Clobenate Ointment 0.05% at room temperature, away from heat and moisture. Keep it in its original container and out of the reach of children.

32. Is Clobenate Ointment 0.05% addictive?

No, Clobenate Ointment 0.05% is not addictive. However, prolonged use may cause side effects such as skin thinning and adrenal suppression.

33. Can I use Clobenate Ointment 0.05% for scalp psoriasis?

Yes, Clobenate Ointment 0.05% is commonly used to treat scalp psoriasis. However, it should be applied carefully and not in excess to avoid potential side effects.

34. Does Clobenate Ointment 0.05% help with skin discoloration?

Clobenate Ointment 0.05% is not typically used to treat skin discoloration or hyperpigmentation. It is more focused on treating inflammation and skin irritation.

35. Can Clobenate Ointment 0.05% be used for bug bites or hives?

Clobenate Ointment 0.05% may help reduce inflammation from insect bites or hives, but milder treatments like antihistamines or hydrocortisone are often recommended first.

36. Can Clobenate Ointment 0.05% help with fungal infections?

Clobenate Ointment 0.05% is not effective against fungal infections. For fungal infections, antifungal treatments are more appropriate.

37. Can I use Clobenate Ointment 0.05% for a rash from poison ivy?

Clobenate Ointment 0.05% may help reduce the inflammation and itching associated with poison ivy, but it should be used with caution and as prescribed by a doctor.

38. How often should I apply Clobenate Ointment 0.05% for psoriasis?

For psoriasis, Clobenate Ointment 0.05% is typically applied once or twice daily. Follow your doctor’s recommendations for frequency and duration of use to avoid potential side effects.

39. Can Clobenate Ointment 0.05% cause acne?

Yes, Clobenate Ointment 0.05% can cause acne-like breakouts in some individuals, especially when used for extended periods or on sensitive areas of the skin.

40. Can I use Clobenate Ointment 0.05% for a rash on my hands?

Clobenate Ointment 0.05% can be used for rashes on the hands, but it should be applied cautiously and for a limited duration to avoid potential skin thinning.

41. Can I use Clobenate Ointment 0.05% for itchy skin?

Clobenate Ointment 0.05% can help relieve itching caused by inflammatory skin conditions, but it is not intended for general itching or mild irritations. Your doctor may recommend a different treatment for these symptoms.

42. Can Clobenate Ointment 0.05% cause hair loss?

In rare cases, Clobenate Ointment 0.05% can cause hair loss, especially if it is used in large amounts or for extended periods.

43. Can Clobenate Ointment 0.05% be used for rashes caused by allergies?

Clobenate Ointment 0.05% can help with rashes caused by allergic reactions, but it is not the first-line treatment. Antihistamines or other medications may be more appropriate for allergic rashes.

44. Can Clobenate Ointment 0.05% be used for rosacea?

Clobenate Ointment 0.05% is generally not recommended for rosacea due to its potency and potential to worsen the condition.

45. Is Clobenate Ointment 0.05% safe for long-term use?

Clobenate Ointment 0.05% is not recommended for long-term use due to the potential for serious side effects, including skin thinning, stretch marks, and other systemic effects. It should be used only for short-term treatment under medical supervision.

46. How soon should I see improvements after using Clobenate Ointment 0.05%?

Many people see improvements within a few days to a week. However, the timeline can vary depending on the condition being treated and individual skin response.

47. Can Clobenate Ointment 0.05% be used for acne scars?

Clobenate Ointment 0.05% is not typically used for treating acne scars. It is primarily used for inflammatory skin conditions.

48. What are the alternatives to Clobenate Ointment 0.05%?

Alternatives to Clobenate Ointment 0.05% include other corticosteroids, such as hydrocortisone, betamethasone, and triamcinolone. These may be less potent and suitable for less severe conditions.

49. Can I use Clobenate Ointment 0.05% for a rash caused by medication?

If you develop a rash from a medication, you should consult your doctor before using Clobenate Ointment 0.05%. Your doctor may recommend an alternative treatment or adjust your medication regimen.

50. How should I dispose of Clobenate Ointment 0.05%?

Dispose of unused or expired Clobenate Ointment 0.05% according to local regulations or return it to a pharmacy for proper disposal. Do not flush it down the toilet or throw it in the trash.

Medical review

Last reviewed: 24 Jul 2026

Medically reviewed by:

This is general information, not personal medical advice. Consult a doctor before taking any medicine.