Bendamax IV Infusion

Bendamax IV Infusion 25 mg/vial Introduction

Bendamax IV Infusion 25 mg/vial is a drug used to treat several types of cancer. It belongs to the family of drugs called alkylating agents, which work by preventing cancer cells from reproducing. Bendamax IV Infusion 25 mg/vial was approved by the U.S. Food and Drug Administration (FDA) in 2008 for treatment of chronic lymphocytic leukemia (CLL). It is also used to treat other cancers, such as non-Hodgkin’s lymphoma, multiple myeloma, and metastatic breast cancer.

Uses for Bendamax IV Infusion 25 mg/vial

Bendamax IV Infusion 25 mg/vial is approved for use in the United States for the treatment of:

Chronic lymphocytic leukemia (CLL)
Non-Hodgkin’s lymphoma (NHL)
Multiple myeloma
B-cell lymphoma
Metastatic breast cancer

Brand Name	Bendamax
Type	IV Infusion
Weight	25 mg/vial
Generic	Bendamustine
Manufacturer	Beacon Pharmaceuticals Ltd.
Available in	English বাংলা

Mechanism of Action

Bendamax IV Infusion 25 mg/vial works by interfering with the growth and development of cancer cells. It prevents them from dividing and reproducing. By stopping the growth of cancer cells, bendamustine helps to slow or stop the spread of cancer.

How Long Does it Take to Work?

Bendamax IV Infusion 25 mg/vial usually begins to work within a few weeks of starting treatment. It is usually given in cycles of two, three, or four weeks, with two weeks off in between cycles. Results will depend on the individual and the type of cancer being treated. Your doctor will be able to provide a better estimate of how long it will take for you to get results from bendamustine.

Absorption

Bendamax IV Infusion 25 mg/vial is absorbed through the small intestine and into the bloodstream. It is then distributed to the organs of the body.

Route of Elimination

Bendamax IV Infusion 25 mg/vial is eliminated from the body through the kidneys. It is excreted in urine and feces.

Dosage and Administration

The dose of bendamustine will vary for each patient depending on their age, weight, type of cancer, and overall health. Your doctor will determine the best dose for you. This medicine is usually given as an intravenous infusion, which takes about 30 minutes to complete. Bendamax IV Infusion 25 mg/vial can also be given as a subcutaneous injection. In that case, it needs to be given twice a week for five to six weeks.

Side Effects

Bendamax IV Infusion 25 mg/vial can cause side effects. Common side effects may include:

Nausea and vomiting
Diarrhea
Constipation
Fatigue and weakness
Hair loss
Mouth sores
Decreased appetite
Weight loss
Fever
Rash
Cough
Dizziness
Low blood cell counts

Toxicity

High doses of bendamustine can be toxic and cause severe side effects. Call your doctor right away if you experience any of the following signs of bendamustine toxicity:

Nausea and vomiting
Diarrhea
Fever
Hair loss
Easy bruising or bleeding
Shortness of breath
Yellowing of the skin or eyes

Precautions

Talk to your doctor before using bendamustine if you have any of the following conditions:

Kidney or liver disease
History of blood clots
High blood pressure
Chronic infection
HIV infection

Interactions

Bendamax IV Infusion 25 mg/vial may interact with other medications. Tell your doctor about all the medications and supplements you are taking before starting this drug, including over-the-counter medications.

Disease Interactions

Bendamax IV Infusion 25 mg/vial may interact with certain medical conditions. Tell your doctor about any medical conditions you may have, including kidney or liver disease, high blood pressure, or HIV infection.

Drug Interactions

Bendamax IV Infusion 25 mg/vial may interact with other medications. Tell your doctor about all medications you are taking, including over-the-counter medications.

Food Interactions

Bendamax IV Infusion 25 mg/vial may interact with certain foods. Tell your doctor about any changes in your diet before starting bendamustine.

Pregnancy Use

Bendamax IV Infusion 25 mg/vial is not recommended for use during pregnancy. Tell your doctor if you are pregnant or planning to become pregnant before taking this medication.

Lactation Use

Bendamax IV Infusion 25 mg/vial is not recommended for use while breastfeeding. Tell your doctor if you are breastfeeding before taking this medication.

Acute Overdose

If you think someone has overdosed on bendamustine, seek medical attention right away. Symptoms of an acute overdose may include nausea, vomiting, diarrhea, fever, weakness, and blood in the urine.

Contraindication

Bendamax IV Infusion 25 mg/vial is contraindicated in people who are allergic to it or any of its components.

Use Directions

Bendamax IV Infusion 25 mg/vial should be used exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take larger or smaller doses than prescribed. Bendamax IV Infusion 25 mg/vial should be taken exactly as prescribed and your doctor will give you detailed instructions. Do not change your dose without talking to your doctor.

Storage Condition

Store bendamustine at room temperature. Keep away from heat and moisture. Do not freeze. Keep out of reach of children and pets.

Volume of Distribution

Bendamax IV Infusion 25 mg/vial has a volume of distribution of approximately 30 L/kg.

Half Life

The half-life of bendamustine is approximately 2-3 hours.

Clearance

The clearance of bendamustine is approximately 5000 mL/min.

Dosage Information

The recommended dosage of bendamustine is based on the individual's age, weight, type of cancer, and overall health. In general, bendamustine is taken as an intravenous infusion, usually given as 1-2 doses over a 30-minute period. For some people, it may also be given as a subcutaneous injection. In that case, it needs to be given twice weekly for five to six weeks. Your doctor will determine the best dose for you.

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