Introduction
ATV Plus Tablet 5 mg+10 mg is a combination of two medications, Amlodipine Besilate and Atorvastatin, that work together to help lower blood pressure and cholesterol levels. Amlodipine Besilate is a calcium channel blocker while Atorvastatin is a statin. The combination helps reduce the risk of coronary heart disease, stroke, and angina.Uses For
ATV Plus Tablet 5 mg+10 mg is used to:- Lower blood pressure
- Lower cholesterol
- Decrease the risk of coronary heart disease, stroke, and angina
Mechanism of Action
Amlodipine Besilate works by blocking calcium from entering the muscle cells in the walls of the arteries of the heart. This prevents the muscle cells from contracting, thus allowing blood to flow more easily and lower the blood pressure. Atorvastatin works by blocking the production of cholesterol in the liver, as well as by preventing cholesterol from being reabsorbed in the intestines. This helps to lower blood cholesterol levels.How Long Does it Take to Work?
The effects of ATV Plus Tablet 5 mg+10 mg can take up to two weeks to be fully effective. It is important to take the medication consistently for full benefits.Absorption
Amlodipine Besilate is quickly and completely absorbed after oral administration. Atorvastatin is also readily absorbed after oral administration.Route of Elimination
Amlodipine Besilate is completely metabolized in the liver and is excreted through the kidneys. Atorvastatin is also excreted primarily through the kidneys.Dosage
Amlodipine: The usual initial antihypertensive oral dose is 5 mg once daily with a maximum dose of 10 mg once daily. Elderly individuals or patients with hepatic insufficiency may be started on 2.5 mg once daily dose and this dose may be used when adding Amlodipine to other antihypertensive therapy. Dosage should be adjusted according to each patient's need. The recommended dose for chronic stable or vasospastic angina is 5-10 mg, with the lower dose suggested in the elderly and in patients with hepatic insufficiency.Atorvastatin:
- The patient should be placed on a standard cholesterol-lowering diet before receiving Atorvastatin and should continue on this diet during treatment with Atorvastatin Hypercholesterolemia (Heterozygous Familial and Nonfamilial) and Mixed Dyslipidemia (Fredrickson Types IIa and IIb): The recommended starting dose of Atorvastatin is 10 mg daily. The dosage range is 10 to 80 mg once daily. Atorvastatin can be administered as a single dose at any time of the day with or without food.
- Homozygous Familial Hypercholesterolemia: The dosage of Atorvastatin in patients with homozygous FH is 10 to 80 mg daily.
- Patients with renal insufficiency: Renal disease has no influence on the plasma concentrations or lipid effects of Atorvastatin; thus no adjustment of dose is required. Hemodialysis is not expected to significantly enhance the clearance of Atorvastatin since the drug is extensively bound to plasma proteins.
- Patients with hepatic dysfunction: In patients with moderate to severe hepatic dysfunction, the therapeutic response to Atorvastatin is unaffected but exposure to the drug is greatly increased.
Administration
ATV Plus Tablet 5 mg+10 mg should be taken once daily with or without food.Side Effects
Common side effects of ATV Plus Tablet 5 mg+10 mg include:- Headache
- Nausea
- Vomiting
- Stomach pain
- Diarrhea
- Dizziness
- Insomnia
- Muscle and joint pain
- Increased thirst
Toxicity
ATV Plus Tablet 5 mg+10 mg has not been reported to be an orally toxic medication. However, it is important to take the medication as prescribed and not overdose. Overdoses of the medication may cause serious side effects that may require medical attention.Precautions
Patients taking ATV Plus Tablet 5 mg+10 mg should avoid grapefruit and alcohol and should not use this medication if they are pregnant. Patients should also inform their doctor of any other medications they are taking as certain drugs may interact with ATV Plus Tablet 5 mg+10 mg.Interactions
ATV Plus Tablet 5 mg+10 mg may interact with other medications including:- Ketoconazole
- Grapefruit juice
- Cyclosporine
- Some antibiotics
- HIV/AIDS medications
- Cholesterol-lowering drugs
- Antifungal medications
Disease Interactions
ATV Plus Tablet 5 mg+10 mg should be avoided by patients with:- Liver disease
- Kidney disease
- Diabetes
- Gout
- Democratic Fibrillation
- Hypothyroidism
Drug Interactions
ATV Plus Tablet 5 mg+10 mg may interact with certain drugs, including:- Ketoconazole
- Grapefruit juice
- Cyclosporine
- Some antibiotics
- HIV/AIDS medications
- Cholesterol-lowering drugs
- Antifungal medications
