Advast Tablet

Introduction

Advast Tablet 5 mg+10 mg is a combination of two medications, Amlodipine Besilate and Atorvastatin, that work together to help lower blood pressure and cholesterol levels. Amlodipine Besilate is a calcium channel blocker while Atorvastatin is a statin. The combination helps reduce the risk of coronary heart disease, stroke, and angina.

Uses For

Advast Tablet 5 mg+10 mg is used to:

Lower blood pressure
Lower cholesterol
Decrease the risk of coronary heart disease, stroke, and angina

Brand Name	Advast
Type	Tablet
Weight	5 mg+10 mg
Generic	Amlodipine Besilate + Atorvastatin
Manufacturer	Alco Pharma Ltd.
Available in	English বাংলা

Mechanism of Action

Amlodipine Besilate works by blocking calcium from entering the muscle cells in the walls of the arteries of the heart. This prevents the muscle cells from contracting, thus allowing blood to flow more easily and lower the blood pressure. Atorvastatin works by blocking the production of cholesterol in the liver, as well as by preventing cholesterol from being reabsorbed in the intestines. This helps to lower blood cholesterol levels.

How Long Does it Take to Work?

The effects of Advast Tablet 5 mg+10 mg can take up to two weeks to be fully effective. It is important to take the medication consistently for full benefits.

Absorption

Amlodipine Besilate is quickly and completely absorbed after oral administration. Atorvastatin is also readily absorbed after oral administration.

Route of Elimination

Amlodipine Besilate is completely metabolized in the liver and is excreted through the kidneys. Atorvastatin is also excreted primarily through the kidneys.

Dosage

Amlodipine: The usual initial antihypertensive oral dose is 5 mg once daily with a maximum dose of 10 mg once daily. Elderly individuals or patients with hepatic insufficiency may be started on 2.5 mg once daily dose and this dose may be used when adding Amlodipine to other antihypertensive therapy. Dosage should be adjusted according to each patient's need. The recommended dose for chronic stable or vasospastic angina is 5-10 mg, with the lower dose suggested in the elderly and in patients with hepatic insufficiency.

Atorvastatin:

The patient should be placed on a standard cholesterol-lowering diet before receiving Atorvastatin and should continue on this diet during treatment with Atorvastatin Hypercholesterolemia (Heterozygous Familial and Nonfamilial) and Mixed Dyslipidemia (Fredrickson Types IIa and IIb): The recommended starting dose of Atorvastatin is 10 mg daily. The dosage range is 10 to 80 mg once daily. Atorvastatin can be administered as a single dose at any time of the day with or without food.
Homozygous Familial Hypercholesterolemia: The dosage of Atorvastatin in patients with homozygous FH is 10 to 80 mg daily.
Patients with renal insufficiency: Renal disease has no influence on the plasma concentrations or lipid effects of Atorvastatin; thus no adjustment of dose is required. Hemodialysis is not expected to significantly enhance the clearance of Atorvastatin since the drug is extensively bound to plasma proteins.
Patients with hepatic dysfunction: In patients with moderate to severe hepatic dysfunction, the therapeutic response to Atorvastatin is unaffected but exposure to the drug is greatly increased.

Advast Tablet 5 mg+10 mg is available in a 5 mg/20 mg dosage. The recommended starting dosage is one tablet of Advast Tablet 5 mg+10 mg 5 mg/20 mg per day taken once daily with or without food. The dosage may be adjusted to a maximum of 10 mg/40 mg per day, depending on the patient's response. It is important to take Advast Tablet 5 mg+10 mg exactly as prescribed.

Administration

Advast Tablet 5 mg+10 mg should be taken once daily with or without food.

Side Effects

Common side effects of Advast Tablet 5 mg+10 mg include:

Headache
Nausea
Vomiting
Stomach pain
Diarrhea
Dizziness
Insomnia
Muscle and joint pain
Increased thirst

Toxicity

Advast Tablet 5 mg+10 mg has not been reported to be an orally toxic medication. However, it is important to take the medication as prescribed and not overdose. Overdoses of the medication may cause serious side effects that may require medical attention.

Precautions

Patients taking Advast Tablet 5 mg+10 mg should avoid grapefruit and alcohol and should not use this medication if they are pregnant. Patients should also inform their doctor of any other medications they are taking as certain drugs may interact with Advast Tablet 5 mg+10 mg.

Interactions

Advast Tablet 5 mg+10 mg may interact with other medications including:

Ketoconazole
Grapefruit juice
Cyclosporine
Some antibiotics
HIV/AIDS medications
Cholesterol-lowering drugs
Antifungal medications

Disease Interactions

Advast Tablet 5 mg+10 mg should be avoided by patients with:

Liver disease
Kidney disease
Diabetes
Gout
Democratic Fibrillation
Hypothyroidism

Drug Interactions

Advast Tablet 5 mg+10 mg may interact with certain drugs, including:

Ketoconazole
Grapefruit juice
Cyclosporine
Some antibiotics
HIV/AIDS medications
Cholesterol-lowering drugs
Antifungal medications

Food Interactions

Advast Tablet 5 mg+10 mg should not be taken with grapefruit or grapefruit juice as this can interfere with the absorption of the medication.

Pregnancy Use

Advast Tablet 5 mg+10 mg should not be used during pregnancy as it can cause birth defects.

Lactation Use

Advast Tablet 5 mg+10 mg is not recommended for women who are breastfeeding as it may be excreted in breast milk and may harm the nursing infant.

Acute Overdose

Symptoms of an acute overdose of Advast Tablet 5 mg+10 mg may include low blood pressure, dizziness, headache, nausea, and skin rash. It is important to seek immediate medical attention if an overdose is suspected.

Contraindication

Advast Tablet 5 mg+10 mg is contraindicated in patients with liver and kidney disease, diabetes, gout, atrial fibrillation, and hypothyroidism.

Use Direction

Advast Tablet 5 mg+10 mg should be taken once daily, with or without food. The starting dose is typically one 5 mg/20 mg tablet per day. The dosage may be adjusted as needed with the maximum recommended dose being one 10 mg/40 mg tablet per day.