Molecular Biology MCQ

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• How many subunits of Spo11 are involved in the process of cleavage of DNA?
  ক

  1

  খ

  2

  গ

  3

  ঘ

  4
• What is the function of the Spo11 in meiotic recombination?
  ক

  Introduction of mutation

  খ

  Introduction of nick

  গ

  Introduction of DSB

  ঘ

  Introduction of lesion
• What are homologs?
  ক

  Part of DNA

  খ

  Pair of nucleus

  গ

  Pair of chromosomes

  ঘ

  Part of a cell
• For which biological phenomenon homologous recombination is critical?
  ক

  Mitosis

  খ

  Meiosis

  গ

  Fragmentation

  ঘ

  Sporing
• What is non-disjunction?
  ক

  Proper alignment

  খ

  Sister chromatid formation

  গ

  Failed alignment

  ঘ

  Chromosome segregation
• How many cycles are required for the configuration of chromosomes?
  ক

  1

  খ

  2

  গ

  3

  ঘ

  4
• Processing of the DNA at the break site occurs at the 3’ end.
  ক

  True

  খ

  False
• What are the components of the MRX protein?
  ক

  MreII, Rad50, Xrs2

  খ

  Rad51, Rad52, Rad59

  গ

  RecA, RuvC, RuvAB

  ঘ

  Rad51C, WRN, BLH
• What is the source of energy during the action of SPO11?
  ক

  Cleavage of peptide bond

  খ

  Cleavage of amide bond

  গ

  Cleavage of glycoside bond

  ঘ

  Cleavage of phosphodiester bond
• What is the cleavage site of RuvC?
  ক

  5’….A/TTTG/C….3’

  খ

  5’….G/TTTC/T….3’

  গ

  5’….T/TGCG/C….3’

  ঘ

  5’….C/ATTG/T….3’
• After cleaved by RuvC the resulting ligated recombination products will only be the splice product.
  ক

  True

  খ

  False
• Which component cleaves the specific DNA strands at the Holliday junction?
  ক

  RuvC

  খ

  RuvD

  গ

  RuvA

  ঘ

  RuvB
• The RuvAB complex specifically recognizes the Holliday junction in an ATP dependent manner.
  ক

  True

  খ

  False
• What is the joint molecule?
  ক

  RecB of the RecBCD pathway

  খ

  B DNA

  গ

  Z DNA

  ঘ

  Rec A bound three stranded structure
• What is the central protein of homologous recombination?
  ক

  RecB

  খ

  RecD

  গ

  RecA

  ঘ

  RecC
• If the foreign DNA lacks the Chi site what will happen?
  ক

  Chi site of DNA will destroy

  খ

  Foreign DNA is not affected

  গ

  Foreign DNA easily enters the cell

  ঘ

  DNA sequence will be intact as previous
• What is the sequence of the Chi site that is highly found in the E. coli genome?
  ক

  GATAATCC

  খ

  GCTGGTGGC

  গ

  CCGGACCTT

  ঘ

  ATGCCGCC
• The nuclease activity of the RecBCD is prone to digest the bacterial cell wall from foreign DNA.
  ক

  True

  খ

  False
• How many times the frequency is increased by the Chi sites?
  ক

  ≈10 fold

  খ

  ≈20 fold

  গ

  ≈30 fold

  ঘ

  ≈40 fold
• What is the speed of driving the RecBCD along the DNA?
  ক

  More than 2000 bp per second

  খ

  More than 1000 bp per second

  গ

  More than 200 bp per second

  ঘ

  More than 100 bp per second
• What are the two components of RecBCD pathway involved as motor parts?
  ক

  RecB, RecD

  খ

  RecB, RecC

  গ

  RecB, RecA

  ঘ

  RecC, RecD
• What is the function of Rec component?
  ক

  5’→3’ helicase activity

  খ

  3’→5’ helicase activity

  গ

  Recognize Chi sites

  ঘ

  Nuclease activity
• What are the helicase components of the RecBCD pathway?
  ক

  RecB, RecC

  খ

  RecC, RecD

  গ

  RecB, RecD

  ঘ

  RecA, RecB
• Chi is the control site of the RecBCD pathway.
  ক

  True

  খ

  False
• RecBCD pathway is an ATP dependent process.
  ক

  True

  খ

  False
• RecBCD enzyme has polymerase and transcriptase activity.
  ক

  True

  খ

  False
• What is the holiday junction resolving enzyme?
  ক

  RecA

  খ

  RuvC

  গ

  Rad52

  ঘ

  Rad59
• In bacteria specific proteins are involved in the RecBCD pathway.
  ক

  True

  খ

  False
• RecBCD and RecFOR in E. coli is involved in the process ____________
  ক

  Assembly of strand exchange

  খ

  Holiday junction recognition

  গ

  Introduction of DSB

  ঘ

  Resolution process
• RecA protein of E. coli is involved in the process of ____________
  ক

  Pairing of homologous DNA

  খ

  Introduction of DSB

  গ

  Assembly of strand exchange

  ঘ

  Resolution of Holiday junction