Chromatin Centromere and Telomere MCQ

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• In cancer telomerase activity __________
  ক

  Increases

  খ

  Decreases

  গ

  Remains constant

  ঘ

  Plays no role
• How does telomerase activity depend on age?
  ক

  Directly

  খ

  Inversely

  গ

  Remains the same

  ঘ

  Does not occur
• Which of the following nucleotides is rich I telomere of an organism?
  ক

  A, T

  খ

  T, G

  গ

  G, C

  ঘ

  C, A
• Telomere is not related to __________
  ক

  Maintenance

  খ

  Chromosome degradation

  গ

  Division

  ঘ

  Replication
• Which alternate form of histone is seen in centromeric histones of humans?
  ক

  H2A.z

  খ

  SMC protein

  গ

  H1

  ঘ

  CENP-A
• The centromere is A/T rich region.
  ক

  True

  খ

  False
• How many satellite sequence elements are present in yeast centromere?
  ক

  2

  খ

  3

  গ

  4

  ঘ

  5
• Centromeric DNA was initially defined in ___________
  ক

  Bacteria

  খ

  Fungi

  গ

  Yeast

  ঘ

  Human
• The protein that binds to the spindle fibres are known as centromeric proteins.
  ক

  True

  খ

  False
• With respect to centromere which of the following is wrong?
  ক

  Constricted chromosomal region

  খ

  Holds the sister chromatids together

  গ

  Attaches to spindle fibres

  ঘ

  Facilitates even distribution
• The part that plays a critical role in even distribution of parental DNA during division is ___________
  ক

  Telomere

  খ

  Centromere

  গ

  Spindle fibre

  ঘ

  Centrioles
• At which phase do transcription ceases?
  ক

  Interphase

  খ

  Prophase

  গ

  S phase

  ঘ

  G phase
• Why are chromosomes condensed?
  ক

  To facilitate accommodation

  খ

  Always condensed

  গ

  To facilitate cell division

  ঘ

  To facilitate distribution in daughter cells
• The whole length of DNA is transcriptionally active.
  ক

  True

  খ

  False
• The extent of chromosome coiling in non – dividing cells is _________
  ক

  Supercoiled

  খ

  Euchromatin

  গ

  Condensed

  ঘ

  Heterochromatin
• Nucleosome was first described in 1974 by ___________
  ক

  William Asbury

  খ

  Rosalind Franklin

  গ

  Roger Kornberg

  ঘ

  John Crick