Antidote of organophosphorus poisoning is

Antidote of organophosphorus poisoning is Correct Answer Atropine

Explanation:

  • Organophosphorus (OP) poisoning commonly results from exposure to pesticides. OP inhibits acetylcholinesterase, leading to accumulation of acetylcholine in the body. Atropine sulfate, an anticholinergic agent is used to counter the cholinergic effects produced by accumulated acetylcholine.
  • Protocol to administer Atropine in case of OP poisoning:

Inject 1.8-3 mg (3-5 mL) of atropine bolus.

  • Check pulse, blood pressure and chest crackles after 5 minutes.
  • Aim for heart rate > 80 beats per minute, SBP > 80 mm Hg, and a clear chest (atropine won't dry focal areas of aspiration).
  • Double the atropine dose at every five minutes if the objectives are not achieved
  • Review patient at every 5 minutes.
  • Once these parameters start improving, repeat last same of smaller dose of atropine.
  • If improvement in these parameters is persistent and satisfactory after 5 minutes, now atropine infusion can be planned.
  • Ignore pupils-they take time to dilate.

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