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The cause of abnormality of hemoglobin in sickle cell anemia is:

The cause of abnormality of hemoglobin in sickle cell anemia is: Correct Answer The presence of valine at the sixth position in the β-chain

The correct answer is The presence of valine at the sixth position in the β-chain

  • Sick cell anemia (Sickle cell anemia) is caused by Abnormal levels of hemoglobin.
  • Sickle cell anemia is caused by an error in a gene that makes the beta-globin chain of hemoglobin.
  • The resultant abnormal hemoglobin (sickle hemoglobin) deforms the red blood cells when they are under low oxygen conditions.
  • Children who inherit 2 copies of the sickle gene, one from each parent, have sickle cell anemia.

Key Points

  • Hemoglobin, or hemoglobin, abbreviated Hb or Hgb, is the iron-containing oxygen-transport metalloprotein in the red blood cells of almost all vertebrates as well as the tissues of some invertebrates.
  • Hemoglobin in the blood carries oxygen from the lungs or gills to the rest of the body.
  • The normal range for hemoglobin is:
    • For men, 13.5 to 17.5 grams per deciliter.
    • For women, 12.0 to 15.5 grams per deciliter.
  • Hemoglobin is a molecule inside the red blood cells of human blood.

Important Points

  • Hemoglobin has two parts:
    • Heme: The heme contains iron and transports oxygen from the lungs to the tissues as well as takes carbon dioxide from the tissues to the lungs. 
    • Globin: The globins are a superfamily of heme-containing globular proteins, involved in binding and/or transporting oxygen. These proteins all incorporate the globin fold, a series of eight alpha-helical segments.

Related Questions

Consider the following statements.
1. The sickle cell anaemia is a genetic disease common in tropical and sub-tropical countries.
2. The sickle-cell anaemia is due to mutation in b-globulin gene.
3. Due to the sickle-shaped anaemia, oxygen carrying capacity of the haemoglobin decreases.
Which of the statements given above is/are correct?
Sickle-cell anemia is a disease caused due to the abnormality in
Which of these are the possible cause of sickle cell anemia with respect to hemoglobin:
In patients of sickle cell anemia, the hemoglobin contains a substitution for ____________________
The sequence of amino acids in hemoglobin molecules of humans is more similar to the hemoglobin of chimpanzees than it is to the hemoglobin of dogs. This similarity suggests that
Who discovered the inheritance of sickle cell anemia disease?
Why sickle cell anemia occurs?
Sickle cell anemia is which type of mutation?
Sickle cell anemia is a result of _______________
Which proteolytic enzyme was used in the experiments aimed at elucidating the mutation that causes sickle cell anemia?