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A dopamine receptor agonist such as bromocriptine (Parlodel) relieves muscle rigidity caused by antipsychotic medication by:

A dopamine receptor agonist such as bromocriptine (Parlodel) relieves muscle rigidity caused by antipsychotic medication by: Correct Answer Activating dopamine receptors in the CNS

  • Dopamine agonists are the broad category of medications that mimic the actions of dopamine in the body to relieve symptoms related to low levels of dopamine. So the Bromocriptine activates dopamine receptors in the brain.
  • Bromocriptine belongs to a class of medication known as  anticholinergics that acts by blocking a certain natural substance (acetylcholine).
  • Extrapyramidal effects and the muscle rigidity induced by antipsychotic medications are caused by a low level of dopamine
  • Bromocriptine stimulates dopamine receptors in the brain. Bromocriptine also reduces the amount of the hormone prolactin that the body produces.
  • It helps in reducing muscle stiffness, sweating, and the production of saliva, and helps improve walking ability in people with Parkinson's disease.
  • Bromocriptine is an  derivative with dopaminergic properties which may act by stimulating dopamine receptors.
  • Dose available in tablets of 2.5 and 10 mg.
  • The starting dose is 2.5 mg and gradually increased to around 20 mg daily.

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