The first-order Markov chain is generally used when.
A
Transition probabilities are fairly stable
B
Change in transition probabilities is random
C
No sufficient data are available
D
All of the above
Correct Answer: Transition probabilities are fairly stable
The first-order Markov chain is generally used when transition probabilities are fairly stable. The first order Markov chain transition probability is the conditional probability that the second amino acid occurs in a two-amino-acid sequence, given the occurrence of the first amino acid, ie P(second amino acid|first amino acid).