Cells deficient in hypoxanthine guanine phosphoribosyl-transferase (HPRT) enzyme rely on

Cells deficient in hypoxanthine guanine phosphoribosyl-transferase (HPRT) enzyme rely on Correct Answer Synthesis of purine deoxynucleotides by de novo pathway

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Related Questions

Lesch-Nyhan syndrome is caused by the deficiency of the enzyme hypoxanthine-guanine phosphoribosyl transferase (HGPRT). Cells deficient in HGPRT die in a medium containing which of the following?
HAT (hypoxanthine, aminopterin and thymidine) is used for selecting the hybridomas based on the following
I. Only hybridoma will grow since it inherited the HGPRT genes from B-cells and can synthesize DNA from hypoxanthine.
II. Myeloma cells will not grow in cultures since de novo synthesis is blocked by aminopterin and due to the lack of HGPRT enzyme.
Cells deficient in hypoxanthine guanine phospho-ribosyl transferase (HGPRT)
Which of the following statement(s) is/are CORRECT for antigen activated effector T cells?
P. CD4+ cells make contact with macrophages and stimulate their microbicidal activity.
Q. CD4+ cells make contact with B cells and stimulate them to differentiate into plasma cells.
R. CD8+ cells make contact with B cells and stimulate them to differentiate into plasma cells.
S. CD8+ cells make contact with virus infected cells and kill them.
A hybrid derived from the fusion of a myeloma cell (HPRT−) with an antibody secreting B-lymphocyte (HPRT+) can be selected to produce monoclonal antibody by growing in a medium containing
Consider the following statements and choose the correct answer:
1. Adenine pairs with thymine (A : T) and guanine with cytosine $$\left( {G \vdots C} \right)$$
2. Adenine and thymine are joined by three hydrogen bonds through atoms
3. Guanine and cytosine are joined by two hydrogen bonds through atoms
4. The weak hydrogen bonding enables the two strands of the DNA to separate during replication
Which of the following statements are correct regarding common differences between plant and animal cells?
1. Plant cells have cellulose cell wall, while animal cells lack it.
2. Plant cells lack plasma membrane, while animal cells have it.
3. Mature plant cell have a large vacuole, while animal cells have numerous small vacuoles.
De novo pathway is exploited for the selection of cells carrying functional HPRT and TK genes.
Which of the following statements regarding soil is/are correct? 1.Alluvial soils are rich in nitrogen content. 2.Black soils are rich in iron and lime but deficient in nitrogen. 3.Laterite soils are rich in iron and aluminium but deficient in nitrogen and potassium. Select the correct answer using the code given below.
Which of the following statements about immune response are correct?
P. T cells are activated by antigen-presenting cells.
Q. Foreign peptides are not presented to helper T cells by class II MHC proteins.
R. Dendritic cells are referred to as professional antigenpresenting cells.