The transport that will be the most affected following mutation III cystic fibrosis transmembrane conductance regulator (CFTR) gene is

In epithelial cells expressing the cystic fibrosis mutation, the CFTR protein is not functional. How does this contribute to the symptoms of the disorder?

A

Stimulated by a buildup of epinephrine, muscle cells contract and produce coughing.

B

Airways are constricted as a result of the buildup of water in epithelial cells.

C

Cells unable to move Cl- across the plasma membrane die, and cellular debris produces thick mucus.

D

Thick mucus develops in the lungs because water is not induced to cross the plasma membrane by an electrochemical gradient.

Which of the following statements about gene therapy are correct?
P. Affected individuals, but not their progeny, can be cured through germline gene therapy.
Q. Affected individuals, as well as their progeny, can be cured through germline gene therapy.
R. Affected individuals, but not their progeny, can be cured through somatic gene therapy.
S. Affected individuals, as well as their progeny, can be cured through somatic gene therapy.

A

P and R only

B

P and S only

C

Q and R only

D

Q and S only

Which of the following are commonly used as reporter genes?
P. NPTgene
Q. Luciferase gene
R. CFTR gene
S. GFP gene

A

Q, S

B

R, S

C

P, R

D

P, Q

Which of the following pairs are correctly matched ? A. Missense mutation - Substitution of one amino acid for another B. Nonsense mutation - The altéred DNA sequence is a stop codon C. Frame shift mutation - The subsequent amino acids are altered D. Silent mutation - There is no change in the DNA sequence

A

A,B and C

B

B, C and D

C

A, B and D

D

A, B, C and D

From the description of cystic fibrosis above, which of the following statements is correct?

A

The disease is similar to cancer in that it has both an environmental and a genetic cause.

B

Cystic fibrosis is an example of a genetic disease caused by polygenic inheritance because several genes must be mutated in order for the disease to occur.

C

Cystic fibrosis is an example of pleiotropy because one mutated gene causes multiple effects.

D

A person who has one cystic fibrosis allele will have the disease.

In cystic fibrosis in a 10 year-old-girl

A

More common in consanguinous marriage

B

Next generation may become carrier

C

Any one of her parents may be found affected

D

All her siblings will be affected

E

Prognosis is good

Cystic fibrosis is associated with

A

Recurrent cough

B

Chronic or recurrent diarrhea

C

Poor weight gain

D

Non-consanguineous parents

E

Sweat chloride test <60 mmol/L

Cystic fibrosis is

A

Autosomal dominant disorder

B

Sex-linked recessive disorder

C

Sex-linked dominant disorder

D

Autosomal recessive disorder

The neonatal feature of cystic fibrosis is?

A

Bronchitis

B

Bronchiolitis

C

Meconium ileus

D

Bronchiectasis

Which mode of inheritance is found in cystic fibrosis ?

A

Autosomal recessive

B

Autosomal dominant

C

Multifactorial inheritance

D

X-linked recessive

The transport that will be the most affected following mutation III cystic fibrosis transmembrane conductance regulator (CFTR) gene is

Related Questions