Which of the following characteristics is suitable for transdermal drug?

Which of the following characteristics is suitable for transdermal drug? Correct Answer Drugs with narrow therapeutic indices

The transdermal route is unsuitable when the drug dose is large when the drug has a large molecular size, the drug is skin sensitizing and irritating. It also becomes a problem when the drug is metabolized in the skin, the drug goes protein binding in the skin, or even if the drug is highly lipophilic or hydrophilic.
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