The renal clearance of a drug bound to plasma protein is increased after displacement with another drug.

The renal clearance of a drug bound to plasma protein is increased after displacement with another drug. Correct Answer True

When another drug displaces one drug which was previously bound to plasma protein, the renal clearance of the later increases. Gentamicin induced nephrotoxicity by furosemide is an example of this. Furosemide does not precipitate by its diuretic effect but by displacing gentamicin from binding sites.

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