Which enzyme converts pregnenolone to progesterone in the first step of the synthesis of mineralocorticoids?
Which enzyme converts pregnenolone to progesterone in the first step of the synthesis of mineralocorticoids? Correct Answer 3-β-OH-steroid dehydrogenase and Δ 4,5-isomerase
Cholesterol is converted to pregnenolone in the first step of mineralocorticoid synthesis. In smooth ER, pregnenolone is then converted into progesterone catalyzed by the enzymes 3-β-OH-steroid dehydrogenase and Δ 4,5-isomerase.