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In an experiment you mutate the consensus sequence at the -10 box. You observe the rate of transcription reduces. Now you make complementary mutation to the sigma factor. What will you observe?

In an experiment you mutate the consensus sequence at the -10 box. You observe the rate of transcription reduces. Now you make complementary mutation to the sigma factor. What will you observe? Correct Answer Original transcription rate

Complementary mutation in sigma factor helps to restore its -10 box recognition capacity which restores normal transcription rate. However, to improve the rate further both the -10 and -35 box sequences should be made more like the consensus.

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