To your cultured cell lines, you add growth factors like cytokines which act through MAPK cascade pathway. Which transition will it trigger?
To your cultured cell lines, you add growth factors like cytokines which act through MAPK cascade pathway. Which transition will it trigger? Correct Answer G1->S
One of the primary checkpoints to overcome incase of proliferation is G1 -> S check point. MAPK cascade leads to transcription of genes required to increase the CDK activity that leads to this transition. Once S phase is completed the cell must undergo mitosis although there is another checkpoint before Anaphase.
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Feb 20, 2025