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The hierarchical clustering method generates a similarity score for all gene combinations, places the scores in a matrix, joins those genes that have the highest score, and then continues to join progressively less similar pairs.

The hierarchical clustering method generates a similarity score for all gene combinations, places the scores in a matrix, joins those genes that have the highest score, and then continues to join progressively less similar pairs. Correct Answer for all gene combinations, places the scores in a matrix, joins those genes that have the highest score, and then continues to join progressively less similar pairs. ] True

The disadvantage of this method is that it fails to discriminate between different patterns of variation. For example, a gene expression pattern for which a high value is found at an intermediate time point will be clustered with another for which a high value is found at a late time point in the experiment. These variations have to be separated in a subsequent step.

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