The postsynaptic neuron becomes fatigued after repeatative stimulation of an excitatory synapse at a rapid rate. This is due to

The postsynaptic neuron becomes fatigued after repeatative stimulation of an excitatory synapse at a rapid rate. This is due to Correct Answer Exhaustion of neurotransmitter store in presynaptic terminal, Progressive inactivation of many postsynaptic receptors, Slow development of abnormal concentration of ions in postsynaptic neurons

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Listening to music during exercise improves exercise performance and reduces discomfort. Scientists researched whether listening to music while studying can help students learn better and the results were inconclusive. Students who needed external stimulation for studying fared worse while students who did not need any external stimulation benefited from music.  Which one of the following statements is the CORRECT inference of the above passage? 
Central excitatory effects of morphine are
I am fatigued ----- wide travelling.