Which of the following is the correct assumptions regarding the respiratory balance sheet? There is a sequential, orderly pathway functioning, with one substrate forming the next and with glycolysis, TCA cycle, and ETS pathway following one after another. The NADH synthesized in glycolysis is transferred into the mitochondria and undergoes oxidative phosphorylation.
Which of the following is the correct assumptions regarding the respiratory balance sheet? There is a sequential, orderly pathway functioning, with one substrate forming the next and with glycolysis, TCA cycle, and ETS pathway following one after another. The NADH synthesized in glycolysis is transferred into the mitochondria and undergoes oxidative phosphorylation. Correct Answer Both are correct
The correct answer is 3 i.e. Both are correct,
Respiratory balance sheet:
- It is possible to make calculations of the net gain of ATP for every glucose molecule oxidized, but in reality, this can remain only a theoretical exercise.
- These calculations can be made only on certain assumptions that:
- There is a sequential, orderly pathway functioning, with one substrate forming the next and with glycolysis, TCA cycle, and ETS pathway following one after another.
- The NADH synthesized in glycolysis is transferred into the mitochondria and undergoes oxidative phosphorylation.
- None of the intermediates in the pathway are utilized to synthesize any other compound.
- Only glucose is being respired – no other alternative substrates are entering in the pathway at any of the intermediary stages.
- But this kind of assumption is not valid in a living system; all pathways work simultaneously and do not take place one after another.
- Substrates enter the pathways and are withdrawn from it as and when necessary.
- ATP is utilized as and when needed; enzymatic rates are controlled by multiple means.
- Yet, it is useful to do this exercise to appreciate the beauty and efficiency of the living system in the extraction and storing energy.
- Hence, there can be a net gain of 36 ATP molecules during aerobic respiration of one molecule of glucose.
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Feb 20, 2025