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Which Antimalarial Drug causes contraindications in pregnancy?

Which Antimalarial Drug causes contraindications in pregnancy? Correct Answer Primaquine

Concept:-

Antimalarial Drug:

The aims of using drugs in relation to malarial infection are:

  • To prevent the clinical attack of malaria
  • To treat and completely eradicate the parasite from the patient’s body.
  • To cut down human-to-mosquito transmission.

Primaquine is an antimalarial drug and it causes contraindications in pregnancy.

Explanation:-

Primaquine:

  • It does not affect the sporozoites and erythrocytic stage of the parasite. However, it has a gametocidal action and is the most effective antimalarial drug for preventing transmission of the disease in all four species of plasmodia.
  • It is almost invariably used in combination with another drug usually chloroquine. Resistance to primaquine is rare.

Mechanism of action:

  • Metabolites of primaquine are believed to act as oxidants that are responsible for schizonticidal action. 

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