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Syndrome, fish-odor: An inborn error of metabolismassociated with an offensive body odor, the smell of rotting fish, due to the excessiveexcretion of trimethylaminuria (TMA) in urine, sweat, and breath. Persons with TMA mayexperience tachycardia (fast heart rate) and severe hypertension ( high blood pressure)after eating cheese (which contains tyramine) and after using nasal sprays containingepinephrine. TMA is caused by a mutation (change) in the gene for an enzyme,flavin-containing monooxygenase-3 (FMO3) encoded by a gene on chromosome #1. The FMO3enzyme metabolizes tyramine (which is in cheese). The syndrome is associated with variouspsychosocial reactions, including social isolation, clinical depression and attempted suicide.