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Speckled iris: Due to little white (or lightly colored) spots that are slightly elevated on the surface of the iris. These spots, arranged in a ring concentric with the pupil, occur in normal children but are far more frequent in Down's syndrome ( trisomy 21). They were described in 1924 by Thomas Brushfield, are called Brushfield's spots, and are due to aggregation of a normal iris element (connective tissue).
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