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Anti-Rabies IM/SC Injection contains Rabies Vaccine (Human)
Anti-Rabies IM/SC Injection side effects
Minor local reactions like pain, erythema, oedema, pruritus and induration at the injection site and lasting to 248 hours. Moderate fever, shivering, fainting, asthenia, dizziness, respiratory manifestations (dyspnoea, wheezing), fever, abdominal pain, vomiting and allergic skin reactions (urticaria, rash, itching).
Precaution:
- Intravenous injection is prohibited.
- The vaccine and anti-rabies immunoglobulin must not be administered with same syringe and in the same injection site.
- Before use, please carefully check package, label, appearance and the validity period.
- After reconstitution, the freeze-dried rabies vaccine should be administered as soon as possible.
- Do not shake during and after reconstitution.
Special precaution for the intradermal route:
- It is essential that intradermal administration of vaccine be administered only by medical staff trained in the ID technique in order to ensure that the vaccine is delivered intradermally and not subcutaneously.
- For the intradermal route a sterile syringe with fixed needle (insulin type) is preferred.
- A sterile needle and syringe must be used to withdraw and administer each dose of vaccine for each patient to avoid cross infection. Correct intradermal injection should result in a raised papule with a orange peel appearance. If the vaccine has been injected too deeply and a papule is not seen, the needle should be withdrawn and re-inserted nearby.
- This vaccine does not contain a preservative, therefore, great care must be taken to avoid contamination of reconstituted vaccine.
- Any reconstituted vaccine should be used as soon as possible. It must be stored in a refrigerator at +2 °C to +8 °C and used within 8 hours after reconstitution or discarded.
- ID route must not be used in the following conditions : Patient receiving immunosuppressive therapies, including irradiation, anti metabolites, alkylating agents, cytotoxic drugs and corticosteroids. Immunocompromised individuals.
Concurrent use with immunosuppressants may reduce the efficacy of vaccines.
Pregnancy. The potential risk of administration of rabies vaccine during pregnancy is unknown. Due to the severity of the disease, pregnancy is not considered to be a contraindication to post-exposure prophylaxis.
Lactation: It is not known whether the vaccine is excreted in human breast milk. Due to the severity of the disease, breast-feeding is not considered a contraindication.
Rabies vaccine is contraindicated in the following cases:Pre-exposure-
- Severe fever, febrile infection, acute disease, progressive chronic diseases
- Known hypersensitivity reactions to rabies vaccine or any of its components Post-exposure
- No contraindication to post-exposure treatment, because rabies is lethal disease, any contraindication to exposure, treatment should be considered carefully before disqualifying an individual for anti-rabies treatment.
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