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Deltasone LA Injection contains Methyl Prednisolone Acetate
Deltasone LA Injection side effects
Adrenal suppression, anaphylactoid reactions, immunosuppression, acute myopathy, Kaposi’s sarcoma, psychiatric disturbances (e.g. depression, euphoria, insomnia, mood swings, personality changes), increased susceptibility and severity of infections, impaired healing, HTN, Na and fluid retention, CV collapse (high dose), peptic ulcer, cataract subcapsular, skin atrophy, acne, muscular weakness, growth retardation, decreased blood K; dermal/subdermal skin depression at inj site. Topical: Itching, burning erythema, vesiculation; rarely, folliculitis, hypertrichosis, perioral dermatitis, skin discolouration, allergic skin reactions.
Patient with heart failure, HTN, DM, GI disease (e.g. diverticulitis, intestinal anastomoses, peptic ulcer, ulcerative colitis), multiple sclerosis, myasthenia gravis, acute MI, cataracts, glaucoma, osteoporosis, history of seizure disorder, thyroid disease. Avoid abrupt withdrawal. Renal and hepatic impairment (including cirrhosis). Childn. Pregnancy and lactation.
Loss of corticosteroid-induced adrenal suppression with aminoglutethimide. Risk of hypokalaemia with K-depleting agents (e.g. amphotericin B, diuretics). Decreased clearance with macrolide antibiotics. May decrease serum levels of isoniazid. Increased clearance with cholestyramine. Risk of convulsions with ciclosporin. Increased risk of arrhythmias with digitalis glycosides. Decreased metabolism with oestrogens, including OCs. Enhanced metabolism with CYP3A4 inducers (e.g. rifampicin, barbiturates). Increased plasma concentrations with CYP3A4 inhibitors (e.g. ketoconazole, erythromycin). Risk of GI effects with aspirin or other NSAIDs. May increase the anticoagulant effect of warfarin. May reduce the therapeutic effect of antidiabetics.
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Systemic fungal infections unless specific anti-infective therapy is employed; IM admin in idiopathic thrombocytopenic purpura. Intrathecal admin. Concurrent admin of live or live, attenuated vaccines (in patients receiving immunosuppressive doses).
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