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Vitilen Lotion contains Methoxsalen
Vitilen Lotion side effects
Major Side Effects are-
- Blistering and peeling of skin
- reddened, sore skin
- swelling, especially of the feet or lower legs
There is an increased risk of developing skin cancer after use of methoxsalen. You should check the treated areas of your body regularly and show your doctor any skin sores that do not heal, new skin growths, and skin growths that have changed in the way they look or feel.
Premature aging of the skin may occur as a result of prolonged methoxsalen therapy. This effect is permanent and is similar to the result of sunbathing for long periods of time.
Patient exhibiting multiple basal cell carcinoma or history of basal cell carcinoma, previous arsenic therapy, previous x-ray or grenz ray therapy; cardiac diseases or those unable to tolerate prolonged standing or exposure to heat stress; GI diseases or chronic infection. Hepatic impairment. Pregnancy and lactation.
May increase plasma concentration of drugs metabolised by CYP2A6 isoenzyme. Additive effect with other systemic or topical photosensitising agents (e.g. anthralin, coal tar, nalidixic acid).
Methoxsalen lotion has been assigned to pregnancy category C by the FDA. Animal reproduction studies have not been conducted with topical methoxsalen, although it has been shown to be a potent photocarcinogen in certain strains of mice. There are no controlled data in human pregnancy. It is also not known to what extent, if any, methoxsalen is absorbed systemically following topical administration. Methoxsalen lotion is only recommended for use during pregnancy when benefit outweighs risk.
Aphakia, existing or history of melanoma, invasive squamous cell carcinoma, photosensitivity diseases (e.g. porphyria, acute lupus erythematosus, xeroderma pigmentosum).
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