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Mevelum Effervescent Granules contains Ispaghula Husk + Mebeverine Hydrochloride
Mevelum Effervescent Granules side effects
Common side effects are Hypersensitivity disorders, Conjunctivitis, Rhinitis, Flatulence, abdominal distension, intestinal obstruction, oesophageal obstruction, faecal impaction, Skin rash
Ispaghula and other bulk-forming laxatives may delay or reduce the gastrointestinal absorption of other drugs such as cardiac glycosides, coumarin derivatives, lithium, carbamazepine or vitamins (such as vitamin B12) and minerals (such as calcium, iron, or zinc). For this reason the product should not be taken ½ to 1 hour before or after intake of other medicinal products. Diabetic patients should take ispaghula husk only under medical supervision because adjustment of anti-diabetic therapy may be necessary.
Use of ispaghula husk concomitantly with thyroid hormones requires medical supervision because the dose of the thyroid hormones may have to be adjusted. Ispaghula husk should not be used together with medicinal products known to inhibit peristaltic movement (e.g. opioids). Ispaghula husk increases the water content of stools thus promoting peristalsis. If the peristaltic action of the gut is reduced, there is potential for intestinal obstruction.
Pregnancy: The product should not be used during pregnancy unless considered essential by the physician. There are limited data (less than 300 pregnancy outcomes) from the use of ispaghula husk in pregnant women. Animal studies are insufficient with respect to reproductive toxicity. There are no or limited amounts of data from the use of mebeverine in pregnant women. Animal studies are insufficient with respect to reproductive toxicity
Breast-feeding: This product should not be used in breast-feeding. Mebeverine is excreted in human milk. The excretion of mebeverine in milk has not been studied in animals.
Fertility: There are no clinical data on male or female fertility.
Patients suffering from abnormal constrictions in the gastrointestinal tract, with diseases of the oesophagus and cardia, cases of intestinal obstruction, natural or drug-induced reduction in gut motility, paralytic ileus, or faecal impaction and colonic atony such as senile megacolon. Patients with a sudden change in bowel habit that has persisted more than two weeks. Undiagnosed rectal bleeding following the use of a laxative. Failure to defecate following the use of a laxative. Patients who have difficulty in swallowing or any throat problems
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