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Frad Capsule contains Cephradine
Frad Capsule side effects
Rarely Cefradine may induce a hypersensitivity reaction and gastrointestinal disturbances which include nausea, vomiting, diarrhoea, glossitis, heartburn, dizziness, abdominal pain, candidial overgrowth, vaginitis, skin rashes, urticaria, joint pain and oedema. As with other cephalosporin mild transient eosinophilia, leucopenia, neutropenia and rarely positive direct coombs test and pseudomembraneous colitis have been reported.
There is evidence of partial cross-allergenicity between penicillins and cephalosporins. Therefore Cefradine should be used with caution in patients with known hypersensitivity to penicillins.
Increased risk of nephrotoxicity with loop diuretics. Decreased renal clearance with probenecid.
No teratogenicity has been demonstrated in animals, but safety in pregnancy has not been established. Cefradine is excreted in the breast milk and should be used with caution in lactating mothers.
Patients with known hypersensitivity to the cephalosporin antibiotics.
Directions for reconstitution:
Cefradine powder for suspension : Add 70 ml (14 measuring spoonful) of boiled and cooled water to the dry mixture in the bottle. For ease of preparation add water to the bottle in two portions. Shake the bottle well after each addition of water until all the powder is in suspension.
Cefradine fort powder for suspension :Add 55 ml (with the help of supplied measuring cup) of boiled and cooled water to the dry mixture in the bottle. For ease of preparation add water to the bottle in two portions. Shake the bottle well after each addition of water until all the powder is in suspension.
Cefradine powder for paediatric drops :Add 10 ml (2 measuring spoonful) of boiled and cooled water to the bottle and shake vigorously.
Note: Shake both the suspension and paediatric drops bottle well before each use. Keep the bottle tightly closed.
Cefradine 250 IM/IV Injection :
Intramuscular injection : Add 1.2 ml of supplied water for injection BP to the vial and shake.
Intravenous injection : Add 5 ml of supplied water for injection BP to the vial and shake. The solution should be slowly injected directly into a vein over a 3 to 5 minute period.
Cefradine 500 IM/IV Injection:
Intramuscular injection : Add 2 ml of supplied water for injection BP to the vial and shake.
Intravenous injection : Add 5 ml of supplied water for injection BP to the vial and shake. The solution should be slowly injected directly into a vein over a 3 to 5 minute period.
Cefradine 1 gm IM/IV Injection:
Intramuscular injection : Add 4 ml of supplied water for injection BP to the vial and shake.
Intravenous injection : Add 10 ml of supplied water for injection BP to the vial and shake. The solution should be slowly injected directly into a vein over a 3 to 5 minute period.
Pharmaceutical precaution
Cefradine capsule, powder for suspension, powder for paediatric drops and vial (for injection) should be kept in a cool and dry place, away from light. The reconstituted suspension should be used within 7 days if kept at room temperature or within 14 days if refrigerated. The reconstituted Cefradine injection solution should be used within 2 hours if kept at room temperature or within 12 hours if kept in refrigerator (2°C).
The cephalosporins are potentially nephrotoxic (particularly Cefaloridine) and may enhance the nephrotoxicity of aminoglycoside antibiotics such as Gentamycin and Tobramycin. One should be cautious about the use of any cephalosporin with Frusemide and Ethacrynic acid.
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