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Divastin Plus Tablet contains Amlodipine + Atorvastatin
Divastin Plus Tablet uses for
Amlodipine + Atorvastatin (amlodipine and atorvastatin) is indicated in patients for whom treatment with both amlodipine and atorvastatin is appropriate.
Atorvastatin is indicated as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and triglycerides (TG) levels and to increase HDL-C in patients with primary hypercholesterolemia (heterozygous familial and nonfamilial) and mixed dyslipidemia; as an adjunct to diet for the treatment of patients with elevated serum triglycerides (TG) levels; for the treatment of patients with primary dysbetalipoproteinemia who do not respond adequately to diet; to reduce total-C and LDL-C in patients with homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering treatments (e.g. LDL apheresis) or if such treatments are unavailable. Prior to initiating therapy with atorvastatin, secondary cause for hypercholesterolemia (e.g. poorly controlled diabetes mellitus, hypothyroidism, nephritic syndrome, dysproteinemia, obstructive liver disease, other drug therapy, and alcoholism) should be identified and treated.
Amlodipine is indicated for the patients with mild to moderate hypertension (alone or in combination with other antihypertensives), the treatment of chronic stable and vasospastic angina, Raynaud's disease.
Amlodipine + Atorvastatin may be substituted for its individually titrated components. Patients may be given the equivalent dose of Amlodipine + Atorvastatin or a dose of Amlodipine + Atorvastatin with increased amounts of amlodipine, atorvastatin or both for additional antianginal effects, blood pressure lowering or lipid lowering effect.
Amlodipine + Atorvastatin may be used to provide additional therapy for patients already on one of its components. As initial therapy for one indication and continuation of treatment of the other, the recommended starting dose of Amlodipine + Atorvastatin should be selected based on the continuation of the component being used and the recommended starting dose for the added monotherapy.
Amlodipine + Atorvastatin may be used to initiate treatment in patients with hyperlipidemia and either hypertension or angina. The recommended starting dose of Amlodipine + Atorvastatin should be based on the appropriate combination of recommendations for the monotherapies.
The maximum dose of the amlodipine component of Amlodipine + Atorvastatin is 10 mg once daily. The maximum dose of the atorvastatin component of Amlodipine + Atorvastatin is 80 mg once daily.
Atorvastatin: There is no specific treatment for atorvastatin overdose. In the event of an overdose, the patient should be treated symptomatically, and supportive measures instituted as required. Due to extensive drug binding to plasma proteins, hemodialysis is not expected to significantly enhance atorvastatin clearance.
Amlodipine: There is no well documented experience with amlodipine overdosage. In case of clinically significant hypotension due to amlodipine over dosage, calls for active cardiovascular support including monitoring of cardiac and respiratory function, elevation of extremities and attention to circulating fluid volume and urine output. Since Amlodipine is highly protein-bound, dialysis is unlikely to be of benefit.
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